| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T408067-1ml |
1ml |
现货  |
|
| 英文别名 | (Z)-Tamoxifen, trans-Tamoxifen | (Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Tamoxifen (ICI 46474) |
| 生化机理 | 他莫昔芬（ICI 46474，(Z)-他莫昔芬，反式-他莫昔芬）是一种选择性雌激素受体调节剂（SERM）。他莫昔芬能增强 Hsp90 分子伴侣 ATP 酶的活性。他莫昔芬可诱导细胞凋亡。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrμg that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs91. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation92. Information Tamoxifen (ICI 46474, (Z)-Tamoxifen, trans-Tamoxifen) is a selectiveestrogen receptormodulator (SERM). Tamoxifen enhances theHsp90molecular chaperoneATPaseactivity. Tamoxifen inducesapoptosis. TAM treatment inhibits significantly MCF7 cell proliferation. Low doses of TAM are able to induce structural chromosomal aberrations (deletions, isochromosomes, translocations, and dicentric chromosomes) in both ER+ and ER- breast cancer cells. This genotoxic effect is higher in those cell lines with HER2 gene amplification. Whereas TAM at lower concentrations (0.1-1 μM) induces a cell-cycle arrest, pharmacological concentrations (above 5 μM) of TAM have been found to induce apoptosis of breast cancer cells. 5 μM TAM rapidly induced sustained activation of ERK1/2 in ER-positive breast cancer cell lines (MCF-7 and T47D) In vivo Tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer. However, it is also carcinogenic in human uterus and rat liver. Tm-inducible Cre-loxP systems are being used in broad areas of research and are providing important biologic insights in tissue development, maintenance, and function. Tamoxifen-induced nuclear localization of Cre recombinase is time- and dose-dependent. Higher doses of tamoxifen induce recombination weeks following administration and Lower doses of tamoxifen induce recombination up to one week following administration. Duration of tamoxifen-induced gene recombination is also dose-dependent. Administration of high Tm doses leads to extended CreER nuclear localization. Tm treatment induces side effects that may have physiologic consequences in Tm-inducible models. cell lines：CLL B cells or healthy volunteer T cells or NK cells Concentrations：10-6\u2009mol/L Incubation Time：24, 48, and 96\u2009h Powder Purity:≥99% |
| EC号 | 234-118-0 |
|---|---|
| Isomeric SMILES | CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3 |
| 关联CAS | 10540-29-1,54965-24-1 (citrate) |
| NSC Number | 727681 |
| MeSH Entry Terms | Citrate, Tamoxifen;ICI 46,474;ICI 46474;ICI 47699;ICI-46,474;ICI-46474;ICI-47699;ICI46,474;ICI46474;ICI47699;Nolvadex;Novaldex;Soltamox;Tamoxifen;Tamoxifen Citrate;Tomaxithen;Zitazonium |
| 分子量 | 371.51 |
| Reaxy-Rn | 2062019 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062019&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 31 mg/mL (198.37 mM); Ethanol: 31 mg/mL (198.37 mM); Water: 16 mg/mL (102.38 mM); |
|---|---|
| 熔点 | 97-98 °C (lit.) |
| 象形图 | GHS08, GHS09, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H302: 吞食有害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 H350: 可能导致癌症 H362: 可能对母乳喂养的孩子造成伤害 |
| 预防措施声明 |
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P263: 避免在怀孕期间/哺乳期间接触。 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | KR5919600 |
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