| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T408048-1ml |
1ml |
现货  |
|
| 英文别名 | TFMO 2 | Benzamide, N-[2-methyl-2-(2-phenyl-4-oxazolyl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | TMP195 |
| 生化机理 | TMP195 (TFMO 2) 是一种选择性很强的一流 IIa 类 HDAC 抑制剂，在基于细胞的 IIa 类 HDAC 检测中 IC50 为 300 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information TMP195 TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays. TMP195 has low potency in recombinant class I and IIb HDAC assays, enabling full inhibition of class IIa HDAC activity without inhibition of other HDACs. TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures and significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle (DMSO)-treated M-CSF plus GM-CSF cultures. TMP195 influences human monocyte responses to the colony-stimulating factors CSF-1 and CSF-2 in vitro. In vivo In vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours. TMP195 treatment significantly decreases proliferating tumour cells, most notably at the leading edge of the tumour. The anti-tumour macrophage phenotype induced by TMP195 treatment thus enhances the efficacy and durability of both standard chemotherapeutic regimens and checkpoint blockade immunotherapy in this mouse model of breast cancer. cell lines： Concentrations：300 nM Incubation Time：5 days Powder Purity:≥98% |
| ALogP | 4.525 |
|---|---|
| HBD Count | 1 |
| Rotatable Bond | 7 |
| Isomeric SMILES | CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4 |
|---|---|
| PubChem CID | 67324851 |
| 分子量 | 456.42 |
| 溶解性 | Solubility (25°C) In vitro Water: 24 mg/mL (9.17 mM); |
|---|---|
| DMSO(mg / mL) Max Solubility | 91 |
| DMSO(mM) Max Solubility | 199.3777661 |
| Water(mg / mL) Max Solubility | ＜1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 |
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