1-[2-(三氟甲基)苯基]咪唑, TRPV2 通道阻断剂

13篇引用文献

COA

级别和纯度:

Moligand™

≥98%

CAS编号: 25371-96-4
分子式: C₁₀H₇F₃N₂
分子量: 212.18
MDL号: MFCD00041206
PubChem编号: 1359

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货号 (SKU)	包装规格	是否现货
T162843-250mg	250mg	期货
T162843-1g	1g	期货
T162843-5g	5g	期货

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Immunology/Inflammation (1938) N-取代咪唑类 (4) NO Synthase (134) TRPV2 Channel blocker (3) 功能金属配合物配体 (19) 咪唑类 (426) 杂环含氟砌块 (11)

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基本描述

别名	1-(2-三氟甲基苯基)咪唑
英文别名	NCGC00016047-03 \| 1-(2-trifluoromethylphenyl) imidazole \| 1-(2-Trifluoromethylphenyl)imidazole \| 2-(trifluoromethyl)phenyl-1H-imidazole \| BRD-K36851334-001-05-5 \| BSPBio_001344 \| NCGC00024873-07 \| 1-(2-Trifluoromethyl-phenyl)-1H-imidazole \| MFCD00041206 \|
规格或纯度	Moligand™, ≥98%
英文名称	1-[2-(Trifluoromethyl)phenyl]imidazole
储存温度	2-8°C储存
运输条件	冰袋运输
作用类型	通道阻滞剂
作用机制	TRPV2 通道阻断剂
产品介绍	TRIM是一种有效的一氧化氮合酶 (nitric oxide synthase) 抑制剂。TRIM 在体外抑制小鼠小脑 nNOS 和大鼠肺 iNOS，IC50 值分别为 28.2 和 27.0 µM。具有抗抑郁和抗焦虑作用。 Product description： TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects.
纯度	≥98%

关联靶点（人）

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (1 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CYP3A4 Tclin 细胞色素P450 3A4(Cytochrome P450 3A4) (1 活性数据)

点击查看靶蛋白信息： CYP3A4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TRPV2 Tchem 瞬时受体电位阳离子通道亚家族V成员2(Transient receptor potential cation channel subfamily V member 2) (0 活性数据)

点击查看靶蛋白信息： TRPV2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)

点击查看靶蛋白信息： CHRM1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NOS1 Tchem Nitric-oxide synthase, brain (1786 活性数据)

点击查看靶蛋白信息： NOS1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)

点击查看靶蛋白信息： ALDH1A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)

点击查看靶蛋白信息： CYP2D6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 活性数据)

点击查看靶蛋白信息： FEN1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)

点击查看靶蛋白信息： TDP1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 活性数据)

点击查看靶蛋白信息： LMNA

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 活性数据)

点击查看靶蛋白信息： CBX1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ATXN2 Tbio Ataxin-2 (54410 活性数据)

点击查看靶蛋白信息： ATXN2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 活性数据)

点击查看靶蛋白信息： MEN1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)

点击查看靶蛋白信息： ampC

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Cruzipain (33337 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Gerbillinae (442 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

lef Anthrax lethal factor (7585 活性数据)

点击查看靶蛋白信息： lef

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 活性数据)

点击查看靶蛋白信息： pfk

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 活性数据)

点击查看靶蛋白信息： Mapt

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

nfo Endonuclease 4 (425 活性数据)

点击查看靶蛋白信息： nfo

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	1-[2-(trifluoromethyl)phenyl]imidazole
INCHI	1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H
InChi Key	WZBWBNCQUTXYEL-UHFFFAOYSA-N
Smiles	C1=CC=C(C(=C1)C(F)(F)F)N2C=CN=C2
Isomeric SMILES	C1=CC=C(C(=C1)C(F)(F)F)N2C=CN=C2
PubChem CID	1359
分子量	212.18
Reaxy-Rn	3955637

化学和物理性质

敏感性	对热敏感
沸点	75 °C/0.025 mmHg
熔点	51 °C
分子量	212.170 g/mol
XLogP3	2.600
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	212.056 Da
单同位素质量Monoisotopic Mass	212.056 Da
拓扑极表面积Topological Polar Surface Area	17.800 Å²
重原子数Heavy Atom Count	15
形式电荷Formal Charge	0
复杂度Complexity	217.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。

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引用文献

1. Junfang Zhu, Bo Li. (2023) Synthesis and characterization of a surface imprinting silica gel polymer for the resolution of tetrahydropalmatine enantiomers. Separation Science Plus, 7 (1): (2300136). [10.1002/sscp.202300136]
2. Liu Jun-bo, Chang Hanqi, Zhao Wensi, Liang Dadong, Tang Shanshan, Jin Ruifa. (2021) Theoretical design and preparation of molecularly imprinted polymers of formaldehyde and acrylamide. JOURNAL OF POLYMER RESEARCH, 28 (11): (1-10). [10.1007/s10965-021-02724-6]
3. Qinglong Luo, Yinqiu Wang, Liang Li, Xueli Huang, Zhongfu Cheng, Xueying Wang, Long He. (2021) Hydrothermal synthesis of hydroxyl terminated polymer boron adsorbents. JOURNAL OF SOLID STATE CHEMISTRY, 296 (121977). [10.1016/j.jssc.2021.121977]
4. Junbo Liu, Wensi Zhao, Guangyu Wang, Shanshan Tang, Ruifa Jin. (2020) Simulation of a phenobarbital molecularly imprinted polymerization self-assembly system and its adsorption property. Analytical Methods, 12 (6): (813-821). [10.1039/C9AY02539A]
5. Liu Junbo, Zhao Wensi, Tang Shanshan, Jin Ruifa. (2020) Theoretical Design and Adsorption Properties of Molecularly Imprinted Polymers Obtained from Chloramphenicol and Acrylamide. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 36 (5): (915-920). [10.1007/s40242-019-9267-2]
6. Jun-Bo Liu, Guang-Yu Wang, Shan-Shan Tang, Qian Gao, Da-Dong Liang, Rui-Fa Jin. (2018) Theoretical and experimental research on self-assembly system of molecularly imprinted polymers formed via chloramphenicol and methacrylic acid. JOURNAL OF SEPARATION SCIENCE, 42 (3): (769-777). [PMID:30488565] [10.1002/jssc.201800997]
7. Chunxia Lu, Zonggui Tang, Changbin Liu, Xiaomei Ma. (2018) Surface molecularly imprinted polymers prepared by two-step precipitation polymerization for the selective extraction of oleanolic acid from grape pomace extract. JOURNAL OF SEPARATION SCIENCE, 41 (17): (3496-3502). [PMID:30027558] [10.1002/jssc.201800474]
8. Yunyun Wang, Jixiang Wang, Rujia Cheng, Lin Sun, Xiaohui Dai, Yongsheng Yan. (2018) Synthesis of molecularly imprinted dye-silica nanocomposites with high selectivity and sensitivity: Fluorescent imprinted sensor for rapid and efficient detection of τ-fluvalinate in vodka. JOURNAL OF SEPARATION SCIENCE, 41 (8): (1880-1887). [PMID:29389060] [10.1002/jssc.201701142]
9. Ziyang Lu, Zehui Yu, Jinbo Dong, Minshan Song, Yang Liu, Xinlin Liu, Di Fan, Zhongfei Ma, Yongsheng Yan, Pengwei Huo. (2017) Construction of stable core–shell imprinted Ag-(poly-o-phenylenediamine)/CoFe2O4 photocatalyst endowed with the specific recognition capability for selective photodegradation of ciprofloxacin. RSC Advances, 7 (77): (48894-48903). [10.1039/C7RA09835A]
10. Wang Jixiang, Wang Yunyun, Qiu Hao, Sun Lin, Dai Xiaohui, Pan Jianming, Yan Yongsheng. (2017) A Novel Sensitive Luminescence Probe Microspheres for Rapid and Efficient Detection of τ-Fluvalinate in Taihu Lake. Scientific Reports, 7 (1): (1-11). [PMID:28485402] [10.1038/srep46635]
11. Xiuying Liu, Lijie Zhu, Xue Gao, Yuxin Wang, Haixia Lu, Yiwei Tang, Jianrong Li. (2016) Magnetic molecularly imprinted polymers for spectrophotometric quantification of curcumin in food. FOOD CHEMISTRY, 202 (309). [PMID:26920299] [10.1016/j.foodchem.2016.02.015]
12. Li Lu, Lin Zheng-zhong, Chen Xiao-mei, Zhang Hong-yuan, Lin Yi-dong, Lai Zhu-zhi, Huang Zhi-yong. (2015) Molecularly imprinted polymers for extraction of malachite green from fish samples prior to its determination by HPLC. MICROCHIMICA ACTA, 182 (9): (1791-1796). [10.1007/s00604-015-1513-9]
13. Ziyang Lu, Yingying Luo, Ming He, Pengwei Huo, Tingting Chen, Weidong Shi, Yongsheng Yan, Jianming Pan, Zhongfei Ma, Siyu Yang. (2013) Preparation and performance of a novel magnetic conductive imprinted photocatalyst for selective photodegradation of antibiotic solution. RSC Advances, 3 (40): (18373-18382). [10.1039/C3RA42738B]

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