| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T118876-100mg |
100mg |
现货  |
| |
| T118876-500mg |
500mg |
现货 |
|
| 别名 | 1,6-二甲基-菲并[1,2-b]呋喃-10,11-二酮 |
|---|---|
| 英文别名 | Tanshinone I, analytical standard | AKOS005613012 | NCGC00247624-02 | TanshinoneI | Tanshinone-I | 1,6-Dimethyl-phenanthro[1,2-b]furan-10,11-dione | 1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione | 1,6-dimethylnaphtho[1,2-g]benzofuran-10,11-quinone | AS-6 |
| 规格或纯度 | ≥97% |
| 英文名称 | Tanshinone I |
| 应用 | A biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells.A biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells. |
| 纯度 | ≥97% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504756730 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione |
| INCHI | 1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3 |
| InChi Key | AIGAZQPHXLWMOJ-UHFFFAOYSA-N |
| Smiles | CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C |
| Isomeric SMILES | CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C |
| PubChem CID | 114917 |
| 分子量 | 276.29 |
| 密度 | 1.324 |
|---|---|
| 折光率 | 1.68 |
| 沸点 | 474-522 °C |
| 熔点 | 233-234℃ |
| 分子量 | 276.300 g/mol |
| XLogP3 | 3.700 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 276.079 Da |
| 单同位素质量Monoisotopic Mass | 276.079 Da |
| 拓扑极表面积Topological Polar Surface Area | 47.300 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 471.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 危险声明 |
H413: 可能对水生生物造成长期的有害影响 |
|---|---|
| WGK Germany | 3 |
| 1. Sun Kai, Xue Yuman, Zhang Xin, Li Xiaodong, Zhao Jun, Xu Xilin, Zhang Xiaofeng, Yang Fubiao. (2023) Tanshinone I alleviates steroid-induced osteonecrosis of femoral heads and promotes angiogenesis: in vivo and in vitro studies. Journal of Orthopaedic Surgery and Research, 18 (1): (1-15). [PMID:37391758] [10.1186/s13018-023-03934-y] |
| 2. Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang. (2022) Tanshinone I inhibits doxorubicin-induced cardiotoxicity by regulating Nrf2 signaling pathway. PHYTOMEDICINE, 106 (154439). [PMID:36108374] [10.1016/j.phymed.2022.154439] |
| 3. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
| 4. Zhou Wei, Shi Min, Deng Changping, Lu Sunjie, Huang Fenfen, Wang Yao, Kai Guoyin. (2021) The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza. Horticulture Research, 8 [PMID:33384411] [10.1038/s41438-020-00443-5] |
| 5. Changping Deng, Xiaolong Hao, Min Shi, Rong Fu, Yao Wang, Yi Zhang, Wei Zhou, Yue Feng, Nokwanda P. Makunga, Guoyin Kai. (2019) Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots. PLANT SCIENCE, 284 (1). [PMID:31084862] [10.1016/j.plantsci.2019.03.007] |
| 6. Xu-Xin Zhang, Yun-Feng Cao, Li-Xuan Wang, Xiao-Lin Yuan, Zhong-Ze Fang. (2017) Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs). PHARMACEUTICAL BIOLOGY, [PMID:28466663] [10.3109/13880209.2015.1045621] |
| 7. Man Wang, Wentao Bi, Xiaohua Huang, David Da Yong Chen. (2016) Ball mill assisted rapid mechanochemical extraction method for natural products from plants. JOURNAL OF CHROMATOGRAPHY A, 1449 (8). [PMID:27157426] [10.1016/j.chroma.2016.04.044] |
| 8. Shi Min, Zhou Wei, Zhang Jianlin, Huang Shengxiong, Wang Huizhong, Kai Guoyin. (2016) Methyl jasmonate induction of tanshinone biosynthesis in Salvia miltiorrhiza hairy roots is mediated by JASMONATE ZIM-DOMAIN repressor proteins. Scientific Reports, 6 (1): (1-11). [PMID:26875847] [10.1038/srep20919] |
| 9. Min Shi, Xiuqin Luo, Guanhua Ju, Leilei Li, Shengxiong Huang, Tong Zhang, Huizhong Wang, Guoyin Kai. (2016) Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 64 (12): (2523–2530). [PMID:26753746] [10.1021/acs.jafc.5b04697] |
| 10. Chenchen Zhang, Shan Jiang, Kun Li, Mei Wang, Rongrong Zhu, Xiaoyu Sun, Qingxiu Wang, ShiLong Wang. (2015) The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 150 (181). [PMID:26046496] [10.1016/j.saa.2015.05.062] |
| 11. Jinghui Li, Yan Kang, Ying Wang, Jiaxin Liu, Yingting Wang, Sitong Liu, Yunxi Bu, Xiangqun Li, Jiahan Xie, Zhibing Wang. (2025) Ionic Liquid-Based Polarity-Adjustable Deep Eutectic Solvent Extraction Followed by High-Performance Liquid Chromatography-Diode-Array Detection for the Determination of Liposoluble Anthraquinones in Salvia miltiorrhiza Bge. Root. JOURNAL OF SEPARATION SCIENCE, 48 (3): (e70116). [PMID:40057467] [10.1002/jssc.70116] |
| 12. Shaoping Ma, Changyong Cai, Xuhong Guo, Zhijian Tan. (2025) Selective separation of tanshinone homologs by biocomposite membranes based on poly(ionic liquids) and natural fibers. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 295 (139568). [PMID:39793843] [10.1016/j.ijbiomac.2025.139568] |
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