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3,3',5'-三碘- L -甲状腺氨酸, 甲状腺激素受体-α的激动剂;甲状腺激素受体-β的激动剂

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货号 (SKU) 包装规格 是否现货 价格 数量
T118717-5mg
 5mg 现货 Stock Image
T118717-10mg
 10mg 现货 Stock Image
T118717-25mg
 25mg 现货 Stock Image
T118717-50mg
 50mg 现货 Stock Image
T118717-100mg
 100mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Thyroid Hormone Receptor (35) Thyroid hormone receptor-α Agonist (7) Thyroid hormone receptor-β Agonist (8) Vitamin D Related/Nuclear Receptor (908)
main product photo

基本描述

别名 2-氨基-3-(4-羟基-3,5-二碘苯氧基)-3-碘苯基丙酸 | 碘塞罗宁
英文别名 Reverse T3 | (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid | 3,3',5'-Triiodo-L-thyronine | 3,3,5-Triiodo-L-thyronine | NCGC00344545-01 | Reverse T3 | Tox21_112797_1 | 3,3',5'-T3 | AKOS016843979 | Levothyroxine Impurity K | REV
规格或纯度 Moligand™, ≥97%
英文名称 3,3′,5′-Triiodo-L-thyronine
储存温度 避光,-20°C储存,充氩
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 甲状腺激素受体-α的激动剂;甲状腺激素受体-β的激动剂
产品介绍


Product description：

reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
纯度 ≥97%

关联靶点（人）

THRA Tclin 甲状腺激素受体α(Thyroid hormone receptor alpha) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
THRB Tclin 甲状腺激素受体β(Thyroid hormone receptor beta) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC6A1 Tclin GABA transporter 1 (308 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR1I2 Tchem Pregnane X receptor (6667 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (104 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SULT1B1 Tbio Sulfotransferase family cytosolic 1B member 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO4A1 Tbio Solute carrier organic anion transporter family member 4A1 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Pkm Pyruvate kinase isozymes M1/M2 (66 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc10a1 Bile acid transporter (65 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1c1 Solute carrier organic anion transporter family member 1C1 (11 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC16A2 Monocarboxylate transporter 8 (28 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
INCHI 1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChi Key HZCBWYNLGPIQRK-LBPRGKRZSA-N
Smiles C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
Isomeric SMILES C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I
PubChem CID 644280
分子量 650.97

化学和物理性质

敏感性 对光敏感
分子量 650.970 g/mol
XLogP3 1.700
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 650.79 Da
单同位素质量Monoisotopic Mass 650.79 Da
拓扑极表面积Topological Polar Surface Area 92.800 Ų
重原子数Heavy Atom Count 23
形式电荷Formal Charge 0
复杂度Complexity 402.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H302: 吞食有害

H312: 皮肤接触有害

H332: 吸入有害
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P330: 漱口

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P501: 将内容物/容器处理到。。。

P301+P317: 如果被吞咽：请寻求医疗帮助。

P317: 寻求紧急医疗救助。
WGK Germany 3
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

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找到21个结果

批号(Lot Number) 证书类型 货号
G2510662 分析证书 T118717
G2510668 分析证书 T118717
G2510670 分析证书 T118717
G2510671 分析证书 T118717
G2510672 分析证书 T118717
F2530296 分析证书 T118717
K2418050 分析证书 T118717
C2401539 分析证书 T118717
C2401537 分析证书 T118717
C2401538 分析证书 T118717
C2401540 分析证书 T118717
C2401541 分析证书 T118717
C2401542 分析证书 T118717
C2401543 分析证书 T118717
C2401544 分析证书 T118717
C2401545 分析证书 T118717
C2401546 分析证书 T118717
A2516033 分析证书 T118717
E2421027 分析证书 T118717
B2520033 分析证书 T118717
B2217091 分析证书 T118717

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引用文献

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