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牛磺酸

非选择性内源性甘氨酸受体部分激动剂
52篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
T103829-25g
 25g 现货 Stock Image
T103829-100g
 100g 现货 Stock Image
T103829-500g
 500g 现货 Stock Image
T103829-1kg
 1kg 期货 Stock Image
T103829-2.5kg
 2.5kg 现货 Stock Image
T103829-10kg
 10kg 现货 Stock Image
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main product photo

基本描述

别名 2-氨基乙磺酸
英文别名 aminoethylsulfonic acid | MLS001332383 | Taukard | Taurine (JP17/USP/INN) | TAURINE [MART.] | TAURINE [USP MONOGRAPH] | TAURINE [VANDF] | Tox21_110277 | 1EQV5MLY3D | Aminoethylsulfonic acid (JAN) | Taurine [INN] | HMS2233D19 | SR-01000076144 | EINECS 203-
规格或纯度 Moligand™, ≥99%
英文名称 Taurine
生化机理 脑中最丰富的游离氨基酸之一。抑制性甘氨酸受体的部分激动剂。
运输条件 常规运输
产品介绍

无臭、味微酸。水中溶解度:65 g/l (12°C)，不溶于无水乙醇、乙醚和丙酮；微溶于95%乙醇； 无任何毒副作用。约300℃时分解。有刺激性。 非选择内源性甘氨酸受体激动剂。属必需磺化氨基酸，调节一些细胞的凋亡，参与许多体内代谢活动;蛋氨酸和半胱氨酸的代谢产物。


纯度 ≥99%

关联靶点（人）

ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHN (49357 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
COLO 205 (50209 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KM12 (47707 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
M14 (47487 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SF-295 (48000 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SN12C (47755 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SNB-19 (46794 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TK-10 (45540 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UACC-257 (46019 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UO-31 (46270 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
786-0 (47912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI/ADR-RES (33767 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
T47D (39041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EKVX (44102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H322M (45589 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCC 2998 (41480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HOP-92 (41141 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hs-578T (29457 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SF-268 (49410 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IGROV-1 (47897 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LOX IMVI (44321 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HOP-62 (47048 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-435 (38290 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Galc Galactocerebrosidase (11 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma brucei rhodesiense (7991 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P388 (20296 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L6 (7924 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
fabI Enoyl-acyl-carrier protein reductase (415 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GAP1 General amino-acid permease GAP1 (481 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179601
EC号 203-483-8
分子类型 小分子
IIUPAC Name 2-aminoethanesulfonic acid
INCHI 1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)
InChi Key XOAAWQZATWQOTB-UHFFFAOYSA-N
Smiles C(CS(=O)(=O)O)N
Isomeric SMILES C(CS(=O)(=O)O)N
PubChem CID 1123
分子量 125.15
Beilstein号 1751215

化学和物理性质

溶解性 溶于water, 最高浓度 (mg/mL): 12.51, 最高浓度(mM): 100
密度 1
敏感性 对湿度敏感
熔点 300°C
分子量 125.150 g/mol
XLogP3 -4.100
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 125.015 Da
单同位素质量Monoisotopic Mass 125.015 Da
拓扑极表面积Topological Polar Surface Area 88.800 Ų
重原子数Heavy Atom Count 7
形式电荷Formal Charge 0
复杂度Complexity 120.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 2
Merck Index 9074
个人防护装备 Eyeshields,Gloves

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找到43个结果

批号(Lot Number) 证书类型 货号
H2526615 分析证书 T103829
H2526616 分析证书 T103829
H2526778 分析证书 T103829
H2526779 分析证书 T103829
H2526777 分析证书 T103829
G2503516 分析证书 T103829
G2503512 分析证书 T103829
G2503486 分析证书 T103829
D2527404 分析证书 T103829
D2527274 分析证书 T103829
D2527275 分析证书 T103829
D2527421 分析证书 T103829
D2527422 分析证书 T103829
D2527405 分析证书 T103829
L2425445 分析证书 T103829
L2425436 分析证书 T103829
L2425435 分析证书 T103829
L2425446 分析证书 T103829
L2425464 分析证书 T103829
G2404475 分析证书 T103829
G2404481 分析证书 T103829
G2404487 分析证书 T103829
G2404480 分析证书 T103829
L2419006 分析证书 T103829
C2430183 分析证书 T103829
C2430184 分析证书 T103829
I2321673 分析证书 T103829
I2321675 分析证书 T103829
I2321689 分析证书 T103829
I2321737 分析证书 T103829
G2315320 分析证书 T103829
G2315327 分析证书 T103829
G2315366 分析证书 T103829
A2304567 分析证书 T103829
A2304569 分析证书 T103829
A2304728 分析证书 T103829
A2304740 分析证书 T103829
A2304741 分析证书 T103829
A2304745 分析证书 T103829
G2222864 分析证书 T103829
G2222865 分析证书 T103829
A2206867 分析证书 T103829
G2222855 分析证书 T103829

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引用文献

1. J A Sturman,J M Messing,S S Rossi,A F Hofmann,M D Neuringer.  (1988-04-01)  Tissue taurine content and conjugated bile acid composition of rhesus monkey infants fed a human infant soy-protein formula with or without taurine supplementation for 3 months..  Neurochemical research,  13  ((4)): (311-316).  [PMID:3393260]
2. S Ishiwata,K Itoh,T Yamaguchi,N Ishida,M Mizugaki.  (1995-05-01)  Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA..  The Tohoku journal of experimental medicine,  176  ((1)): (61-68).  [PMID:7482520]
3. J Li,R H Foote,M Simkin.  (1993-07-01)  Development of rabbit zygotes cultured in protein-free medium with catalase, taurine, or superoxide dismutase..  Biology of reproduction,  49  ((1)): (33-37).  [PMID:8353188]
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7. A González-Quevedo,F Obregón,R Santiesteban Freixas,R Fernández,L Lima.  (1999-06-01)  [Amino acids as biochemical markers in epidemic and endemic optic neuropathies]..  Revista cubana de medicina tropical,  50 Suppl  (241-244).  [PMID:10349454]
8. Luc A Cynober.  (2002-09-26)  Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance..  Nutrition (Burbank, Los Angeles County, Calif.),  18  ((9)): (761-766).  [PMID:12297216]
9. Kenji Hashimoto,Takeshi Fukushima,Eiji Shimizu,Naoya Komatsu,Hiroyuki Watanabe,Naoyuki Shinoda,Michiko Nakazato,Chikara Kumakiri,Shin-ichi Okada,Hisanori Hasegawa,Kazuhiro Imai,Masaomi Iyo.  (2003-06-11)  Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia..  Archives of general psychiatry,  60  ((6)): (572-576).  [PMID:12796220]
10. Sirpa Rainesalo,Tapani Keränen,Johanna Palmio,Jukka Peltola,Simo S Oja,Pirjo Saransaari.  (2004-03-03)  Plasma and cerebrospinal fluid amino acids in epileptic patients..  Neurochemical research,  29  ((1)): (319-324).  [PMID:14992292]
11. Pietro Amedeo Modesti,Gian Gastone Neri Serneri,Tania Gamberi,Maria Boddi,Mirella Coppo,Gianluca Lucchese,Mario Chiavarelli,Giulia Bottai,Francesco Marino,Camilla Toz Gensini,Gian Franco Gensini,Alessandra Modesti.  (2008-09-23)  Impaired angiotensin II-extracellular signal-regulated kinase signaling in failing human ventricular myocytes..  Journal of hypertension,  26  ((10)): (2030-2039).  [PMID:18806628]
12. Ienaka Takeda,Cynthia Stretch,Pamela Barnaby,Kriti Bhatnager,Kathryn Rankin,Hao Fu,Aalim Weljie,Naresh Jha,Carolyn Slupsky.  (2009-03-05)  Understanding the human salivary metabolome..  NMR in biomedicine,  22  ((6)): (577-584).  [PMID:19259987]
13. Takashi Ito,Stephen W Schaffer,Junichi Azuma.  (2011-03-26)  The potential usefulness of taurine on diabetes mellitus and its complications..  Amino acids,  42  ((5)): (1529-1539).  [PMID:21437784]
14. Doris M Jacobs,Laura Spiesser,Maxime Garnier,Niels de Roo,Ferdi van Dorsten,Boudewijn Hollebrands,Ewoud van Velzen,Richard Draijer,John van Duynhoven.  (2012-08-31)  SPE-NMR metabolite sub-profiling of urine..  Analytical and bioanalytical chemistry,  404  ((8)): (2349-2361).  [PMID:22932811]
15. Roshil Budhram,Kashyap G Pandya,Cesar A Lau-Cam.  (2013-02-09)  Protection by taurine and thiotaurine against biochemical and cellular alterations induced by diabetes in a rat model..  Advances in experimental medicine and biology,  775  (321-343).  [PMID:23392946]
16. Jee Wook Kim,Boung Chul Lee,Tae-Cheon Kang,Ihn-Geun Choi.  (2013-02-13)  The current situation of treatment systems for alcoholism in Korea..  Journal of Korean medical science,  28  ((2)): (181-189).  [PMID:23400047]
17. Renu Agarwal,Igor Iezhitsa,Nur Adilah Awaludin,Nur Farhana Ahmad Fisol,Nor Salmah Bakar,Puneet Agarwal,Thuhairah Hasrah Abdul Rahman,Alexander Spasov,Alexander Ozerov,Mohamed Salama Mohamed Ahmed Salama,Nafeeza Mohd Ismail.  (2013-02-23)  Effects of magnesium taurate on the onset and progression of galactose-induced experimental cataract: in vivo and in vitro evaluation..  Experimental eye research,  110  (35-43).  [PMID:23428743]
18. L Zhao,J-S Lou,Y Kang.  (2013-03-15)  Taurine-magnesium coordination compound attenuates hypoxia/reoxygenation induced ion channel dysfunction in rat ventricular myocytes..  Drug research,  63  ((4)): (185-191).  [PMID:23487402]
19. M Desforges,L Parsons,M Westwood,C P Sibley,S L Greenwood.  (2013-03-23)  Taurine transport in human placental trophoblast is important for regulation of cell differentiation and survival..  Cell death & disease,  4  (e559-e559).  [PMID:23519128]
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