| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S655134-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | SLF |
| 生化机理 | SLF 是一种 FK506 结合蛋白（FKBP）的合成配体，对 FKBP51 的亲和力为 3.1 μM，对 FKBP12 的 IC 50 为 2.6 μM。SLF 可用于合成 PROTAC。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC . In Vitro Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)N |
| PubChem CID | 35027274 |
| 分子量 | 524.65 |
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