SR-31747 free base

COA

CAS编号: 132173-06-9
分子式: C₂₃H₃₄ClN
分子量: 359.98
PubChem编号: 6913112

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货号 (SKU)	包装规格	是否现货
S651368-1mg	1mg	期货
S651368-5mg	5mg	期货
S651368-10mg	10mg	期货
S651368-25mg	25mg	期货
S651368-50mg	50mg	期货

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σ受体 (61) 神经元信号传导 (3320)

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基本描述

别名	SR-31747 游离碱
英文别名	UNII-G622F7P8LU \| Cyclohexanamine, N-(3-(3-chloro-4-cyclohexylphenyl)-2-propenyl)-N-ethyl-, (Z)- \| SCHEMBL6652640 \| C23H34ClN \| 3-(3-chloro-4-cyclohexylphenyl)-n-cyclohexyl-n-ethyl-2(z)-propenylamine \| AKOS015924573 \| N-[(Z)-3-(3-chloro-4-cyclohexylphenyl
英文名称	SR-31747 free base
生化机理	SR-31747 游离碱是一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 通过抑制固醇异构酶阻止细胞增殖。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	SR-31747 free base is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase In Vitro SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED 50 , 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid IC50& Target:Sigma ligand

关联靶点（其它种属）

Sigmar1 Sigma opioid receptor (160 活性数据)

点击查看靶蛋白信息： Sigmar1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Tmem97 Sigma intracellular receptor 2 (922 活性数据)

点击查看靶蛋白信息： Tmem97

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	未知
IIUPAC Name	N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine
INCHI	1S/C23H34ClN/c1-2-25(21-13-7-4-8-14-21)17-9-10-19-15-16-22(23(24)18-19)20-11-5-3-6-12-20/h9-10,15-16,18,20-21H,2-8,11-14,17H2,1H3/b10-9-
InChi Key	MYKJVLTXPNIGOV-KTKRTIGZSA-N
Smiles	CCN(CC=CC1=CC(=C(C=C1)C2CCCCC2)Cl)C3CCCCC3
Isomeric SMILES	CCN(C/C=C\C1=CC(=C(C=C1)C2CCCCC2)Cl)C3CCCCC3
关联CAS	132173-06-9
PubChem CID	6913112
分子量	359.98

化学和物理性质

溶解性	DMSO : 5 mg/mL (13.89 mM; Need ultrasonic)
分子量	360.000 g/mol
XLogP3	7.700
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	1
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	359.238 Da
单同位素质量Monoisotopic Mass	359.238 Da
拓扑极表面积Topological Polar Surface Area	3.200 Å²
重原子数Heavy Atom Count	25
形式电荷Formal Charge	0
复杂度Complexity	395.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	1
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	1
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

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