ST-193

COA

级别和纯度:

≥99%

CAS编号: 489416-12-8
分子式: C₂₄H₂₅N₃O
分子量: 371.47
PubChem编号: 3697969

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货号 (SKU)	包装规格	是否现货
S651102-5mg	5mg	期货
S651102-10mg	10mg	期货
S651102-25mg	25mg	期货
S651102-50mg	50mg	期货

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Anti-infection (2804) Arenavirus (22) Virus (3767)

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基本描述

规格或纯度	≥99%
英文名称	ST-193
生化机理	ST-193 是一种强效的广谱 arenavirus 抑制剂；对 Guanarito、Junin、Lassa 和 Machupo 病毒的抑制作用 IC 50 值分别为 0.44、0.62、1.4 和 3.1 nM。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC 50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively. In Vitro ST-193 inhibits LASV pseudotypes with an IC 50 of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC 50 s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)
纯度	≥99%

关联靶点（其它种属）

Lassa virus (234 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Junin virus (193 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Machupo mammarenavirus (59 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine
INCHI	1S/C24H25N3O/c1-17(2)19-6-4-18(5-7-19)15-25-20-8-13-24-23(14-20)26-16-27(24)21-9-11-22(28-3)12-10-21/h4-14,16-17,25H,15H2,1-3H3
InChi Key	JPSZEXYTKSIPDW-UHFFFAOYSA-N
Smiles	CC(C)C1=CC=C(C=C1)CNC2=CC3=C(C=C2)N(C=N3)C4=CC=C(C=C4)OC
Isomeric SMILES	CC(C)C1=CC=C(C=C1)CNC2=CC3=C(C=C2)N(C=N3)C4=CC=C(C=C4)OC
PubChem CID	3697969
MeSH Entry Terms	ST-193
分子量	371.47

化学和物理性质

溶解性	DMSO : 100 mg/mL (269.20 mM; Need ultrasonic)
分子量	371.500 g/mol
XLogP3	5.700
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	3
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	371.2 Da
单同位素质量Monoisotopic Mass	371.2 Da
拓扑极表面积Topological Polar Surface Area	39.100 Å²
重原子数Heavy Atom Count	28
形式电荷Formal Charge	0
复杂度Complexity	468.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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