| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S648491-5mg |
5mg |
期货  |
| |
| S648491-10mg |
10mg |
期货 |
|
| 英文别名 | 2-fluoro-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyridin-3-yl]pyridine | BDBM50519291 | s77 | SEN177 | 2-luoro-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyridin-3-yl]pyridine | SCHEMBL22736849 | EN300-1700016 | SEN177, >=98% (HPLC) | |
|---|---|
| 规格或纯度 | ≥97% |
| 英文名称 | SEN177 |
| 生化机理 | SEN177 是一种强效谷氨酰胺酰环化酶（QPCT）抑制剂，对谷氨酰胺酰肽环转酶样（QPCTL）的 IC 50 为 0.013μM。SEN177 对人谷氨酰胺酰环化酶（hQC）的 K i 为 20 nM。SEN177 可大大降低突变型 HTT 寡核苷酸对人类谷氨酰胺酰环化酶（hQC）的影响。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates. SEN177 has the potential for Huntington’s disease research. Form:Solid |
| 纯度 | ≥97% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 821-054-9 |
|---|---|
| 分子类型 | 未知 |
| IIUPAC Name | 2-fluoro-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyridin-3-yl]pyridine |
| INCHI | 1S/C18H19FN6/c1-24-12-22-23-17(24)13-6-9-25(10-7-13)18-15(3-2-8-20-18)14-4-5-16(19)21-11-14/h2-5,8,11-13H,6-7,9-10H2,1H3 |
| InChi Key | AJIAMIPUWJQSPR-UHFFFAOYSA-N |
| Smiles | CN1C=NN=C1C2CCN(CC2)C3=C(C=CC=N3)C4=CN=C(C=C4)F |
| Isomeric SMILES | CN1C=NN=C1C2CCN(CC2)C3=C(C=CC=N3)C4=CN=C(C=C4)F |
| 关联CAS | 2117405-13-5 |
| PubChem CID | 91618245 |
| 分子量 | 338.38 |
| 溶解性 | DMSO : 33.33 mg/mL (98.50 mM; Need ultrasonic) |
|---|---|
| 分子量 | 338.400 g/mol |
| XLogP3 | 2.100 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 338.166 Da |
| 单同位素质量Monoisotopic Mass | 338.166 Da |
| 拓扑极表面积Topological Polar Surface Area | 59.700 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 430.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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