| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S613422-5mg |
5mg |
期货  |
| |
| S613422-25mg |
25mg |
期货 |
|
| 别名 | 沙格雷酯 |
|---|---|
| 英文别名 | 4-(1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yloxy)-4-oxobutanoic acid | D08508 | SR-01000883998 | LS-187,118 | STK631325 | DB12163 | J-513134 | NCGC00167489-02 | 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]ox |
| 规格或纯度 | Moligand™ |
| 英文名称 | sarpogrelate |
| 作用类型 | 拮抗剂 |
| 作用机制 | 羟色胺 2a（5-HT2a）受体拮抗剂 |
| ALogP | 1.2 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid |
| INCHI | 1S/C24H31NO6/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27) |
| InChi Key | FFYNAVGJSYHHFO-UHFFFAOYSA-N |
| Smiles | CN(C)CC(COC1=CC=CC=C1CCC2=CC(=CC=C2)OC)OC(=O)CCC(=O)O |
| Isomeric SMILES | CN(C)CC(COC1=CC=CC=C1CCC2=CC(=CC=C2)OC)OC(=O)CCC(=O)O |
| 关联CAS | 125926-17-2 |
| PubChem CID | 5160 |
| MeSH Entry Terms | 2-(dimethylamino)-1-((2-(3-methoxyphenyl)phenoxy)methyl)ethyl hydrogensuccinate hydrochloride;MCI 9042;MCI-9042;mono-(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl)ethyl)succinate hydrochloride;sarpogrelate |
| 分子量 | 429.5 |
| 分子量 | 429.500 g/mol |
|---|---|
| XLogP3 | 1.200 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 14 |
| 精确质量Exact Mass | 429.215 Da |
| 单同位素质量Monoisotopic Mass | 429.215 Da |
| 拓扑极表面积Topological Polar Surface Area | 85.300 Ų |
| 重原子数Heavy Atom Count | 31 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 540.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Muntasir HA, Hossain M, Bhuiyan MA, Komiyama T, Nakamura T, Ozaki M, Nagatomo T. (2007) Identification of a key amino acid of the human 5-HT(2B) serotonin receptor important for sarpogrelate binding.. J Pharmacol Sci, 104 (3): (274-7). [PMID:17609583] |
| 2. Pertz H, Elz S. (1995) In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery.. J Pharm Pharmacol, 47 (4): (310-6). [PMID:7791029] |
| 3. Nishio H, Inoue A, Nakata Y. (1996) Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes.. Arch Int Pharmacodyn Ther, 331 (2): (189-202). [PMID:8937629] |
首页
400-620-6333
