| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S479901-1mg |
1mg |
现货  |
| |
| S479901-5mg |
5mg |
期货 |
|
| 英文别名 | 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | Q27460255 | 1-(2-Deoxy-2-Fluoro-Beta-D-Arabinofuranosyl)-5-Ethynylpyrimidine-2,4(1h,3h)-Dione | 1-(2-Deoxy-2-fluoropentofuranosyl)-5-ethynyl-4-hydroxypyrimid |
|---|---|
| 规格或纯度 | ≥95% |
| 英文名称 | (2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine (F-ara-EdU) |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 底物 |
| 产品介绍 |
F-ara-EdU（2'-脱氧-2'-氟-5-乙炔基尿苷）是胸苷的合成类似物，用于研究从头DNA合成和细胞增殖。它是BrdU（5-溴-2'-脱氧尿苷）和EdU（5-乙炔基-2'-去氧尿苷）的细胞毒性较小的替代品。 应用： 一种比 EdU 和 BrdU 毒性都低的体内 DNA 合成探针。当需要延长细胞存活和未受干扰的细胞周期进展时，非常适合用于代谢 DNA 标记。 A probe for DNA synthesis in vivo that is less toxic than both EdU and BrdU. Ideally suited for metabolic DNA labeling when prolonged cell survival and undisturbed cell cycle progression are required. Application： F-ara-EdU (2’-deoxy-2’-fluoro-5-ethynyluridine) is a synthetic analog of thymidine used to study de novo DNA synthesis and cell proliferation. It is a less cytotoxic alternative for BrdU (5-Bromo-2’-deoxyuridine) and EdU (5-Ethynyl-2’-deoxyuridine). |
| 纯度 | ≥95% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 5-ethynyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| INCHI | 1S/C11H11FN2O5/c1-2-5-3-14(11(18)13-9(5)17)10-7(12)8(16)6(4-15)19-10/h1,3,6-8,10,15-16H,4H2,(H,13,17,18)/t6-,7+,8-,10-/m1/s1 |
| InChi Key | YEEGMPUOCRQFRV-IBCQBUCCSA-N |
| Smiles | C#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F |
| Isomeric SMILES | C#CC1=CN(C(=O)NC1=O)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F |
| PubChem CID | 514810 |
| 分子量 | 270.21 |
| 分子量 | 270.210 g/mol |
|---|---|
| XLogP3 | -1.000 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 270.065 Da |
| 单同位素质量Monoisotopic Mass | 270.065 Da |
| 拓扑极表面积Topological Polar Surface Area | 99.100 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 497.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 信号词 | 危险 |
|---|---|
| 危险声明 |
H300+H310+H330: 吞咽，皮肤接触或吸入会致命。 |
| 预防措施声明 |
P262: 不要进入眼睛、皮肤或衣服。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P301+P310+P330: 如果吞咽：漱口。立即致电中毒中心/医生。 |
| 1. Anne B Neef, Nathan W Luedtke,. (2011-12-07) Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides.. Proceedings of the National Academy of Sciences of the United States of America, 108 ((51)): ( 20404-20409 ). [PMID:22143759] |
首页
400-620-6333
C2416009