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1-硬脂酰-sn-甘油-3-磷酸胆碱, GPR119 的激动剂

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
S465645-5mg
5mg 期货 Stock Image
S465645-100mg
100mg 期货 Stock Image
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代谢物 (8911)

基本描述

英文别名 HY-15440 | LPC 18:0/0:0 | [(2R)-2-hydroxy-3-octadecanoyloxypropyl] 2-trimethylazaniumylethyl phosphate | DB12129 | 18:0 Lyso PC | 1-18:0-lysoPC | AC-30913 | AKOS027323602 | 1-Stearoyl-sn-3-phosphatidylcholine | PC 18:0/0:0 | (R)-2-Hydroxy-3-(stearoyloxy)p
规格或纯度 Moligand™, ≥99%, powder
英文名称 1-Stearoyl-sn-glycero-3-phosphocholine
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 GPR119 的激动剂
纯度 ≥99%

关联靶点(人)

GPR119 Tclin 葡萄糖依赖性胰岛素促泌剂受体(Glucose-dependent insulinotropic receptor) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name [(2R)-2-hydroxy-3-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
INCHI 1S/C26H54NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h25,28H,5-24H2,1-4H3/t25-/m1/s1
InChi Key IHNKQIMGVNPMTC-RUZDIDTESA-N
Smiles CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)O
Isomeric SMILES CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)O
关联CAS 19420-57-6
MeSH Entry Terms 1-octadecyl-glycero-3-phosphocholine;1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine;1-stearoyl-sn-glycero-3-phosphorylcholine;stearoyl alpha-lysolecithin;stearoyl alpha-lysolecithin, (+-)-isomer;stearoyl alpha-lysolecithin, (R)-isomer;stearoyl L-alpha-l
分子量 523.683

化学和物理性质

分子量 523.700 g/mol
XLogP3 6.600
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 7
可旋转键计数Rotatable Bond Count 26
精确质量Exact Mass 523.364 Da
单同位素质量Monoisotopic Mass 523.364 Da
拓扑极表面积Topological Polar Surface Area 105.000 Ų
重原子数Heavy Atom Count 35
形式电荷Formal Charge 0
复杂度Complexity 546.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

信号词 警告
危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

WGK Germany 3
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

引用文献

1. Jongwon Shim,Mi Jin Kim,Han-Kon Kim,Do-Hoon Kim,Seong Geun Oh,Seung Yong Ko,Ho Gyeom Jang,Jin-Woong Kim.  (2010-01-12)  Morphological effect of lipid carriers on permeation of lidocaine hydrochloride through lipid membranes..  International journal of pharmaceutics,  388  ((1-2)): (251-256).  [PMID:20060459]
2. Michał Flasiński,Marcin Broniatowski,Jarosław Majewski,Patrycja Dynarowicz-Łatka.  (2010-05-25)  X-ray grazing incidence diffraction and Langmuir monolayer studies of the interaction of beta-cyclodextrin with model lipid membranes..  Journal of colloid and interface science,  348  ((2)): (511-521).  [PMID:20493495]
3. Patricia Cmielewski,Don S Anson,David W Parsons.  (2010-06-24)  Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length..  Respiratory research,  11  (84-84).  [PMID:20569421]
4. Ji Hoon Jung,Soo-Jin Jeong,Ji-Hyun Kim,Sung-Ki Jung,Deok-Beom Jung,Duckgu Lee,Eun Jung Sohn,Miyong Yun,Hyo-Jung Lee,Hyo-Jeong Lee,Sung-Hoon Kim.  (2013-06-04)  Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells..  Cell biochemistry and biophysics,  67  ((3)): (1379-1389).  [PMID:23729004]
5. Yunpeng Qi,Changtao Jiang,Jie Cheng,Kristopher W Krausz,Tiangang Li,Jessica M Ferrell,Frank J Gonzalez,John Y L Chiang.  (2014-05-07)  Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice..  Biochimica et biophysica acta,  1851  ((1)): (19-29).  [PMID:24796972]
6. Ximena Mora-Cubillos,Sara Tulipani,Mar Garcia-Aloy,Mònica Bulló,Francisco J Tinahones,Cristina Andres-Lacueva.  (2015-09-29)  Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome..  Molecular nutrition & food research,  59  ((12)): (2480-2490).  [PMID:26412215]
7. Santosh Lamichhane,Linda Ahonen,Thomas Sparholt Dyrlund,Heli Siljander,Heikki Hyöty,Jorma Ilonen,Jorma Toppari,Riitta Veijola,Tuulia Hyötyläinen,Mikael Knip,Matej Orešič.  (2018-11-14)  A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes..  Scientific data,  (180250-180250).  [PMID:30422126]
8. Yoeseph Cho,Ji-Hye Woo,Oh-Seung Kwon,Sang Sun Yoon,Junghyun Son.  (2019-04-06)  Alterations in phospholipid profiles of erythrocytes deep-frozen without cryoprotectants..  Drug testing and analysis,  11  ((8)): (1231-1237).  [PMID:30950199]
9. Imad A Haidar Ahmad,Andrei Blasko,James Tam,Narayan Variankaval,Holst M Halsey,Robert Hartman,Erik L Regalado.  (2019-06-15)  Revealing the inner workings of the power function algorithm in Charged Aerosol Detection: A simple and effective approach to optimizing power function value for quantitative analysis..  Journal of chromatography. A,  1603  (1-7).  [PMID:31196588]
10. Sanjeevan Jahagirdar,Edoardo Saccenti.  (2020-12-04)  Evaluation of Single Sample Network Inference Methods for Metabolomics-Based Systems Medicine..  Journal of proteome research,  20  ((1)): (932-949).  [PMID:33267585]
11. G M El Maghraby,B W Barry,A C Williams.  (2008-06-24)  Liposomes and skin: from drug delivery to model membranes..  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,  34  ((4-5)): (203-222).  [PMID:18572392]
12. Asako Katsume,Mitsuhiko Okigaki,Akihiro Matsui,Jishan Che,Yasushi Adachi,Eigo Kishita,Shinichiro Yamaguchi,Koji Ikeda,Tomomi Ueyama,Satoaki Matoba,Hiroyuki Yamada,Hiroaki Matsubara.  (2011-03-05)  Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system..  Arteriosclerosis, thrombosis, and vascular biology,  31  ((5)): (1084-1092).  [PMID:21372295]
13. James Tam,Imad A Haidar Ahmad,Andrei Blasko.  (2018-04-21)  A four parameter optimization and troubleshooting of a RPLC - charged aerosol detection stability indicating method for determination of S-lysophosphatidylcholines in a phospholipid formulation..  Journal of pharmaceutical and biomedical analysis,  155  (288-297).  [PMID:29677679]

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