| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S463196-50mg |
50mg |
期货  |
|
| 英文别名 | [6]-Shogaol;6-Shogaol | 6-Shogaol | AC-34334 | NSC752389 | NSC-752389 | Q2746448 | (E)-1-(4-Hydroxy-3- methoxyphenyl)dec-4-en-3-one | [(E)-1-(4-hydroxy-3-methoxyphenyl)-dec-4-en-3-one] | 1-(4-Hydroxy-3-methoxyphenyl)-4-dodecen-3-one, 9CI | BDBM50237536 | |
|---|---|
| 规格或纯度 | Moligand™, ≥90%(HPLC) |
| 英文名称 | Shogaol |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Description Shogaol or 6-shogaol, the pungent metabolite of dried ginger, is one of the main bioactive compounds extracted from the natural dietary rhizome,Zingiber officinaleRoscoe (ginger). It is the dehydrated successor of 6-gingerol with an α,β-unsaturated ketone skeleton.Shogaol has been used to determine its safe dose to evaluate potential toxicity in higher concentrations in mice models. It has also been used to investigate its antioxidant effects on the modulation of TRPC5 (ITRPC5) and TRPA1 (ITRPA1) currents. |
| 纯度 | ≥90%(HPLC) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 664-006-0 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one |
| INCHI | 1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3/b8-7+ |
| InChi Key | OQWKEEOHDMUXEO-BQYQJAHWSA-N |
| Smiles | CCCCCC=CC(=O)CCC1=CC(=C(C=C1)O)OC |
| Isomeric SMILES | CCCCC/C=C/C(=O)CCC1=CC(=C(C=C1)O)OC |
| 关联CAS | 23513-13-5,555-66-8 |
| NSC Number | 752389 |
| MeSH Entry Terms | (6)-shogaol;6-shogaol;shogaol |
| 分子量 | 276.37 |
| Beilstein号 | 2056098 |
| Reaxy-Rn | 2056098 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2056098&ln= |
| 分子量 | 276.400 g/mol |
|---|---|
| XLogP3 | 3.700 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 276.173 Da |
| 单同位素质量Monoisotopic Mass | 276.173 Da |
| 拓扑极表面积Topological Polar Surface Area | 46.500 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 299.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P501: 将内容物/容器处理到。。。 P301+P317: 如果被吞咽：请寻求医疗帮助。 |
| WGK Germany | 3 |
| 1. Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G. (2017) 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ.. Oncotarget, 8 (26): (42001-42006). [PMID:28410218] |
| 2. Young-Soo Kim,Chan Sik Hong,Sang Weon Lee,Joo Hyun Nam,Byung Joo Kim. (2016-11-15) Effects of ginger and its pungent constituents on transient receptor potential channels.. International journal of molecular medicine, 38 ((6)): (1905-1914). [PMID:27840893] |
| 3. Xingran Kou,Xiaoqi Wang,Ruya Ji,Lang Liu,Yening Qiao,Zaixiang Lou,Chaoyang Ma,Shiming Li,Hongxin Wang,Chi-Tang Ho. (2018-02-09) Occurrence, biological activity and metabolism of 6-shogaol.. Food & function, 9 ((3)): (1310-1327). [PMID:29417118] |
| 4. Jin-Hyung Lee,Yong-Guy Kim,Pilju Choi,Jungyeob Ham,Jae Gyu Park,Jintae Lee. (2018-09-14) Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition.. Frontiers in cellular and infection microbiology, 8 (299-299). [PMID:30211127] |
| 5. H-R Kim,Y-B Eom. (2020-09-28) Antifungal and anti-biofilm effects of 6-shogaol against Candida auris.. Journal of applied microbiology, 130 ((4)): (1142-1153). [PMID:32981148] |
| 6. Ali Ghasemzadeh,Hawa Z E Jaafar,Ali Baghdadi,Amin Tayebi-Meigooni. (2018-07-07) Formation of 6-, 8- and 10-Shogaol in Ginger through Application of Different Drying Methods: Altered Antioxidant and Antimicrobial Activity.. Molecules (Basel, Switzerland), 23 ((7)): [PMID:29976903] |
| 7. Lingli Yang,Fei Yang,Lanting Teng,Ichiro Katayama. (2020-05-21) 6-Shogaol Protects Human Melanocytes against Oxidative Stress through Activation of the Nrf2-Antioxidant Response Element Signaling Pathway.. International journal of molecular sciences, 21 ((10)): [PMID:32429495] |
| 8. Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu. (2023) Inhibition of benzo[a]pyrene formation in charcoal-grilled pork sausages by ginger and its key compounds. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (6): (2838-2847). [PMID:36700254] [10.1002/jsfa.12470] |
| 9. Rui Bao, Qi-Long Wang, Ran Li, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Xi-Ming Xu, Jiang-Nan Yu. (2020) Improved oral bioavailability and target delivery of 6-shogaol via vitamin E TPGS-modified liposomes: Preparation, in-vitro and in-vivo characterizations. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 59 (101842). [10.1016/j.jddst.2020.101842] |
| 10. Huiyun Zhang, Qilong Wang, Congyong Sun, Yuan Zhu, Qiuxuan Yang, Qiuyu Wei, Jiaxin Chen, Wenwen Deng, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu. (2019) Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate. Pharmaceutics, 11 (3): (107). [PMID:30845761] [10.3390/pharmaceutics11030107] |
| 11. Yanni Tai, Mintong Zhao, Feng Ding, Gelin Wu, Haibin Qu, Ping Gong, Yongjian Xie, Peng Zhou, Xingchu Gong. (2024) Analytical quality by design based on knowledge organization: A case study of developing an ultrahigh-performance liquid chromatography method for the detection of phenolic compounds. PHYTOCHEMICAL ANALYSIS, [PMID:38462508] [10.1002/pca.3343] |
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