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三氯蔗糖

23篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
S432919-GMP-10g
 10g 期货 Stock Image
S432919-GMP-50g
 50g 期货 Stock Image
S432919-GMP-250g
 250g 期货 Stock Image
S432919-GMP-1kg
 1kg 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) 二糖 (89) 代谢物 (8911)
main product photo

基本描述

别名 1-(1,6-二氯-1,6-双脱氧-β-D-呋喃果糖)-4-氯-4-脱氧-α-D-半乳糖吡喃糖苷 | E 95
英文别名 Trichlorosucrose | Sucralose | E955 | 1-(1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl)-4-chloro-4-deoxy-α-D-galactopyranoside | 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside
规格或纯度 PharmPure™, ChP, 欧洲药典（Ph.Eur）, JPE, NF, granular
英文名称 Sucralose granular
生化机理 一种人类可以检测到的合成甜味剂。可激活肠内分泌细胞上的 T1R2/T1R3 甜味受体，引起胰高血糖素样肽-1 和葡萄糖依赖性胰岛素肽的激素分泌增加。
储存温度 室温
运输条件 常规运输
产品介绍

三氯蔗糖是无致龋齿性的高倍甜味剂，适合糖尿病和葡萄糖耐受损伤患者。另外，它极易溶于水，可同样轻松地掩盖苦味和药品异味，非常适合制药应用。 我们的三氯蔗糖以均为医药级的粉末或颗粒形式提供，方便用户按需选择。由于极佳的分散能力，粉末型三氯蔗糖通常被推荐用于固体制剂，颗粒型三氯蔗糖则因其快速溶解能力而十分适合液体制剂。

Sucralose is a high-intensity sweetener which is non-cariogenic and suitable for diabetics and patients with an impaired glucose tolerance. In addition, it is readily soluble and masks both bitterness and medicinal off-notes with equal ease – making it exceptionally well-suited for pharmaceutical applications. Our Sucralose is available in micronized or granular form, both pharmaceutical grade, allowing you to choose depending on your individual needs. Due to its optimal dispersion behavior, sucralose powder is typically recommended for solid dose formulations, while the fast dissolution behavior of sucralose granular makes it very well-suited for liquid formulations.

关联靶点（人）

CA2 Tclin 碳酸酐酶2(Carbonic anhydrase 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TAS2R31 Tchem Taste receptor type 2 member 31 (86 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TAS2R10 Tchem Taste receptor type 2 member 10 (51 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK-293T (167025 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TAS2R46 Tchem Taste receptor type 2 member 46 (155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 259-952-2
分子类型 小分子
IIUPAC Name (2R,3R,4R,5R,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol
INCHI 1S/C12H19Cl3O8/c13-1-4-7(17)10(20)12(3-14,22-4)23-11-9(19)8(18)6(15)5(2-16)21-11/h4-11,16-20H,1-3H2/t4-,5-,6+,7-,8+,9-,10+,11-,12+/m1/s1
InChi Key BAQAVOSOZGMPRM-QBMZZYIRSA-N
Smiles C(C1C(C(C(C(O1)OC2(C(C(C(O2)CCl)O)O)CCl)O)O)Cl)O
Isomeric SMILES C([C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CCl)O)O)CCl)O)O)Cl)O
PubChem CID 71485
分子量 397.63
Beilstein号 3654410
Reaxy-Rn 3654410

化学和物理性质

密度 1.62g/cm3at 20°C
比旋光度 86.0° (C=1,H2O)
熔点 130°C
分子量 397.600 g/mol
XLogP3 -1.500
氢键供体数Hydrogen Bond Donor Count 5
氢键受体数Hydrogen Bond Acceptor Count 8
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 396.015 Da
单同位素质量Monoisotopic Mass 396.015 Da
拓扑极表面积Topological Polar Surface Area 129.000 Ų
重原子数Heavy Atom Count 23
形式电荷Formal Charge 0
复杂度Complexity 405.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 9
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

信号词 警告
危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
WGK Germany 3
RTECS LW5440140
Merck Index 8880
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

可替换产品

  1. 三氯蔗糖
    三氯蔗糖
    • 10mM in DMSO

    ¥164.72

  2. 三氯蔗糖粉末
    三氯蔗糖粉末

    ¥129.90

  3. 三氯蔗糖
    三氯蔗糖
    • ≥98%

    ¥31.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Lingling Tian, Jingyan Shi, Wei Li, Yuan Zhang, Xinghua Gao.  (2023)  Hollow Microfiber Assembly-Based Endocrine Pancreas-on-a-Chip for Sugar Substitute Evaluation.  Advanced Healthcare Materials,  (2302104).  [PMID:37751946] [10.1002/adhm.202302104]
2. He Yue, Chen Jianshe, Shi Weiyao, Shi Jingang, Ma Tian, Wang Xinmiao.  (2023)  Can nonvolatile tastants be smelled during food oral processing?.  CHEMICAL SENSES,  48  [PMID:37590987] [10.1093/chemse/bjad028]
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]
4. Xue Mei, Wenchang Wang, Qingyi Li, Minxian Wu, Liyin Bu, Zhidong Chen.  (2023)  A novel electrochemical sensor based on gold nanobipyramids and poly-L-cysteine for the sensitive determination of trilobatin.  ANALYST,  148  (10): (2335-2342).  [PMID:37186001] [10.1039/D3AN00368J]
5. Xuejiao Zhang, Jiaxin Gu, Congying Zhao, Yaozhong Hu, Bowei Zhang, Jin Wang, Huan Lv, Xuemeng Ji, Shuo Wang.  (2022)  Sweeteners Maintain Epithelial Barrier Function Through the miR-15b/RECK/MMP-9 Axis, Remodel Microbial Homeostasis, and Attenuate Dextran Sodium Sulfate-Induced Colitis in Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (1): (171–183).  [PMID:34962394] [10.1021/acs.jafc.1c06788]
6. Xiaofeng Wei, Ying Chen, Shan He, Huiting Lian, Xuegong Cao, Bin Liu.  (2021)  L-histidine-regulated zeolitic imidazolate framework modified electrochemical interface for enantioselective determination of L-glutamate.  ELECTROCHIMICA ACTA,  400  (139464).  [10.1016/j.electacta.2021.139464]
7. Ferry Saputra, Yu-Heng Lai, Rey Arturo T. Fernandez, Allan Patrick G. Macabeo, Hong-Thih Lai, Jong-Chin Huang, Chung-Der Hsiao.  (2021)  Acute and Sub-Chronic Exposure to Artificial Sweeteners at the Highest Environmentally Relevant Concentration Induce Less Cardiovascular Physiology Alterations in Zebrafish Larvae.  Biology-Basel,  10  (6): (548).  [PMID:34207293] [10.3390/biology10060548]
8. Pingping Cui, Qiuxiang Yin, Shihao Zhang, Xiaowei Cheng, Jiayu Dai, Zaixiang Zhang, Ling Zhou, Chuang Xie.  (2020)  The effect of solvents on crystal morphology of sucralose: Experiments and molecular dynamics simulation studies.  JOURNAL OF CRYSTAL GROWTH,  532  (125398).  [10.1016/j.jcrysgro.2019.125398]
9. Yong Li, Tingting Yang, Qing Yao, Songsong Li, En Fang, Yankun Li, Chao Liu, Weimin Li.  (2019)  Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.  NEUROGASTROENTEROLOGY AND MOTILITY,  31  (5): (e13556).  [PMID:30740845] [10.1111/nmo.13556]
10. Yin Xu, Ying Wu, Wei Zhang, Xiaohui Fan, Yan Wang, Hui Zhang.  (2018)  Performance of artificial sweetener sucralose mineralization via UV/O3 process: Kinetics, toxicity and intermediates.  CHEMICAL ENGINEERING JOURNAL,  353  (626).  [10.1016/j.cej.2018.07.090]
11. Hongmei Zhang, Shixin Sun, Yanqing Wang, Zhenghao Fei, Jian Cao.  (2018)  Binding mechanism of five typical sweeteners with bovine serum albumin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  205  (40).  [PMID:30015031] [10.1016/j.saa.2018.07.013]
12. Hongmei Zhang, Shixin Sun, Yanqing Wang, Jian Cao.  (2017)  Interaction of sucralose with whey protein: Experimental and molecular modeling studies.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  187  (92).  [PMID:28666158] [10.1016/j.saa.2017.06.030]
13. Jiang Ting-Fu, Chong Lei, Yue Mei-E, Wang Yuan-Hong, Lv Zhi-Hua.  (2015)  Separation and Determination of Carbohydrates in Food Samples by Capillary Electrophoresis Using Dynamically Coating the Capillary with Indirect UV Detection.  Food Analytical Methods,  8  (10): (2588-2594).  [10.1007/s12161-015-0157-z]
14. Longmei Yao, Xue Mei, Jiajia Zhi, Wenchang Wang, Qingyi Li, Ding Jiang, Xiaohui Chen, Zhidong Chen.  (2024)  A novel electrochemiluminescent sensor based on AgMOF@N-CD composites for sensitive detection of trilobatin.  ANALYST,  [PMID:39264159] [10.1039/D4AN01102C]
15. Dali Zhuo, Xiaoyu Dong, Linghuan Li, Ronghua Zeng, Chao Tan, Hong Luo, Zhirong Zou.  (2025)  Detection of Ca2+ in water samples and calcium gluconate oral liquids using gas pressure meter as portable detector.  MICROCHEMICAL JOURNAL,  (113116).  [10.1016/j.microc.2025.113116]
16. Jingyan Shi, Jianing Li, Wentao Su, Chang Xue, Yuan Zhang, Xinghua Gao.  (2024)  Engineered microenvironments and pancreatic islet-on-chips for screening sugar substitute and antidiabetic compounds.  FOOD RESEARCH INTERNATIONAL,  196  (115084).  [PMID:39614569] [10.1016/j.foodres.2024.115084]
17. Li Hao, Du Yu, Cheng Kaiwen, Chen Yuxi, Wei Ling, Pei Yujun, Wang Xiaoyu, Wang Lan, Zhang Ye, Hu Xiaoxin, Lu Yi, Zhu Xiangjia.  (2024)  Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.  Cell Discovery,  10  (1): (1-14).  [PMID:39187483] [10.1038/s41421-024-00709-5]
18. Li Zhang, Lei Feng, Lin Yang, Hao Wan.  (2025)  Noninvasive Detection and Monitoring of the Integrity of the Intestinal Barrier through NIR-II Fluorescence Imaging and Colorimetric Urinalysis.  ACS Applied Materials & Interfaces,  [PMID:39977645] [10.1021/acsami.4c20263]
19. Zizhang Wang, Hao Li, Yuxiang Weng.  (2024)  OsFKBP12 transduces the sucrose signal from OsNIN8 to the OsTOR pathway in a loosely binding manner for cell division.  iScience,  [PMID:39811636] [10.1016/j.isci.2024.111555]
20. Yue He, Jianshe Chen, Weiyao Shi, Jingang Shi.  (2024)  Retronasal sensation of nonvolatile sweeteners and its impacts on the flavor perception of beverages.  FOOD QUALITY AND PREFERENCE,  115  (105107).  [10.1016/j.foodqual.2024.105107]
21. Jing Xiao, Dali Zhuo, Jiayuan Tang, Jihong Chen, Chao Tan, Shu Zhang, Shichao Li, Zhirong Zou.  (2024)  Selective and sensitive detection of cyclamate in beverages using a portable pressure meter: A specific reaction-based analytical kit.  MICROCHEMICAL JOURNAL,  204  (110959).  [10.1016/j.microc.2024.110959]
22. Luyao Yang, Shuangshuang Wang, Jing Jin, Jiahui Wang, Wenyue Chen, Yun Xue, Liang Sheng, Yongning Zhai, Weifeng Yao.  (2024)  Sucralose triggers insulin resistance leading to follicular dysplasia in mice.  REPRODUCTIVE TOXICOLOGY,  128  (108644).  [PMID:38880404] [10.1016/j.reprotox.2024.108644]
23. Wenjiao Liu, Han wang, Qi Mu, Ting Gong.  (2024)  Taste receptor T1R3 regulates testosterone synthesis via the cAMP-PKA-SP1 pathway in testicular Leydig cells.  THERIOGENOLOGY,  [PMID:39476553] [10.1016/j.theriogenology.2024.10.019]

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