| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S427199-1ml |
1ml |
现货  |
|
| 别名 | S-腺苷-L-高半胱氨酸 |
|---|---|
| 英文别名 | 5'-Deoxy-S-adenosyl-L-homocysteine | CCG-208703 | S-(5'-Adenosyl)-L-homocysteine, crystalline | S-(5'-Deoxyadenosine-5')-L-homocysteine | (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | S-(5′-Adenosyl)-L-homocysteine |
| 生化机理 | 氨基酸衍生物和几种代谢途径的中间产物，副产物或调节剂。DNA甲基转移酶（S-腺苷-L-蛋氨酸（AdoMet）依赖性甲基转移酶）的竞争性抑制剂（与AdoMet相对）。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
SAH 是氨基酸衍生物和几种代谢途径中的调节剂。 它是半胱氨酸和腺苷合成的中间体。SAH 是 METTL3-METTL14 异二聚体复合物 (METTL3-14) 的抑制剂，IC50 为 0.9 µM。 SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 213-560-8 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]butanoic acid |
| INCHI | 1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 |
| InChi Key | ZJUKTBDSGOFHSH-WFMPWKQPSA-N |
| Smiles | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N |
| Isomeric SMILES | C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N |
| PubChem CID | 439155 |
| 分子量 | 384.41 |
| Beilstein号 | 99188 |
| 敏感性 | 对光敏感 |
|---|---|
| 分子量 | 384.410 g/mol |
| XLogP3 | -3.500 |
| 氢键供体数Hydrogen Bond Donor Count | 5 |
| 氢键受体数Hydrogen Bond Acceptor Count | 11 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 384.122 Da |
| 单同位素质量Monoisotopic Mass | 384.122 Da |
| 拓扑极表面积Topological Polar Surface Area | 208.000 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 504.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 5 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Guorong Cheng, Zhiqiang Liu, Zhong Zheng, Fengrui Song, Xiaoyu Zhuang, Shu Liu. (2022) Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (22): (13738). [PMID:36430215] [10.3390/ijms232213738] |
| 2. Jun Xiong, Ke-Ke Chen, Neng-Bin Xie, Tong-Tong Ji, Si-Yu Yu, Feng Tang, Conghua Xie, Yu-Qi Feng, Bi-Feng Yuan. (2022) Bisulfite-Free and Single-Base Resolution Detection of Epigenetic DNA Modification of 5-Methylcytosine by Methyltransferase-Directed Labeling with APOBEC3A Deamination Sequencing. ANALYTICAL CHEMISTRY, 94 (44): (15489–15498). [PMID:36280344] [10.1021/acs.analchem.2c03808] |
| 3. Beijun Ang, Xinxin Xu, Liguang Xu, Liqiang Liu, Hua Kuang, Chuanlai Xu. (2022) Development of a colloidal gold strip assay for the detection of total homocysteine in serum samples. ANALYST, 147 (19): (4348-4355). [PMID:36040794] [10.1039/D2AN01105K] |
| 4. Moli Sang, Qingyu Yang, Jiawei Guo, Peiyuan Feng, Wencheng Ma, Wei Zhang. (2025) Functional investigation of the SAM-dependent methyltransferase RdmB in anthracycline biosynthesis. Synthetic and Systems Biotechnology, 10 (102). [PMID:39308748] [10.1016/j.synbio.2024.09.002] |
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