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6-姜烯酚
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S424730-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | (E)-1-(4-羟基-3-甲氧基苯基)癸-4-烯-3-酮 |
|---|---|
| 英文别名 | [6]-Shogaol;6-Shogaol | 6-Shogaol | AC-34334 | NSC752389 | NSC-752389 | Q2746448 | (E)-1-(4-Hydroxy-3- methoxyphenyl)dec-4-en-3-one | [(E)-1-(4-hydroxy-3-methoxyphenyl)-dec-4-en-3-one] | 1-(4-Hydroxy-3-methoxyphenyl)-4-dodecen-3-one, 9CI | BDBM50237536 | |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | [6]-Shogaol |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
关联靶点（人）
TRPV1
Tclin
瞬时受体电位阳离子通道亚家族V成员1(Transient receptor potential cation channel subfamily V member 1)
(2 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ALOX5
Tclin
Arachidonate 5-lipoxygenase
(6568 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
LTA4H
Tchem
Leukotriene A4 hydrolase
(1442 活性数据)
CYP2C8
Tchem
Cytochrome P450 2C8
(1492 活性数据)
TRPV1
Tclin
Vanilloid receptor
(8273 活性数据)
BCHE
Tclin
Butyrylcholinesterase
(7174 活性数据)
APP
Tclin
Amyloid-beta A4 protein
(8510 活性数据)
CYP2D6
Tclin
Cytochrome P450 2D6
(33882 活性数据)
CYP1A2
Tchem
Cytochrome P450 1A2
(26471 活性数据)
CYP2C9
Tchem
Cytochrome P450 2C9
(32119 活性数据)
CYP2C19
Tchem
Cytochrome P450 2C19
(29246 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
CYP2E1
Tchem
Cytochrome P450 2E1
(2174 活性数据)
CYP2A6
Tchem
Cytochrome P450 2A6
(2861 活性数据)
CYP2B6
Tchem
Cytochrome P450 2B6
(1338 活性数据)
HT-29
(80576 活性数据)
IMR-32
(1082 活性数据)
NCI-H1299
(3248 活性数据)
HCT-116
(91556 活性数据)
HepG2
(196354 活性数据)
NLRP3
Tchem
NACHT, LRR and PYD domains-containing protein 3
(908 活性数据)
关联靶点（其它种属）
Abcb1b
P-glycoprotein 1 (174 活性数据)
Rodentolepis nana (555 活性数据)
PC-12 (7051 活性数据)
RBL-2H3 (1162 活性数据)
C6 (2371 活性数据)
BV-2 (3710 活性数据)
Trpa1
Transient receptor potential cation channel subfamily A member 1 (1003 活性数据)
Plasma (328 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 664-006-0 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one |
| INCHI | 1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3/b8-7+ |
| InChi Key | OQWKEEOHDMUXEO-BQYQJAHWSA-N |
| Smiles | CCCCCC=CC(=O)CCC1=CC(=C(C=C1)O)OC |
| Isomeric SMILES | CCCCC/C=C/C(=O)CCC1=CC(=C(C=C1)O)OC |
| 关联CAS | 23513-13-5,555-66-8 |
| NSC Number | 752389 |
| MeSH Entry Terms | (6)-shogaol;6-shogaol;shogaol |
| 分子量 | 276.37 |
| Beilstein号 | 2056098 |
| Reaxy-Rn | 2056098 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2056098&ln= |
化学和物理性质
| 敏感性 | 对空气、光、和潮气敏感 |
|---|---|
| 分子量 | 276.400 g/mol |
| XLogP3 | 3.700 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 276.173 Da |
| 单同位素质量Monoisotopic Mass | 276.173 Da |
| 拓扑极表面积Topological Polar Surface Area | 46.500 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 299.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P501: 将内容物/容器处理到。。。 P301+P317: 如果被吞咽：请寻求医疗帮助。 |
| WGK Germany | 3 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu. (2023) Inhibition of benzo[a]pyrene formation in charcoal-grilled pork sausages by ginger and its key compounds. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (6): (2838-2847). [PMID:36700254] [10.1002/jsfa.12470] |
| 2. Rui Bao, Qi-Long Wang, Ran Li, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Xi-Ming Xu, Jiang-Nan Yu. (2020) Improved oral bioavailability and target delivery of 6-shogaol via vitamin E TPGS-modified liposomes: Preparation, in-vitro and in-vivo characterizations. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 59 (101842). [10.1016/j.jddst.2020.101842] |
| 3. Huiyun Zhang, Qilong Wang, Congyong Sun, Yuan Zhu, Qiuxuan Yang, Qiuyu Wei, Jiaxin Chen, Wenwen Deng, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu. (2019) Enhanced Oral Bioavailability, Anti-Tumor Activity and Hepatoprotective Effect of 6-Shogaol Loaded in a Type of Novel Micelles of Polyethylene Glycol and Linoleic Acid Conjugate. Pharmaceutics, 11 (3): (107). [PMID:30845761] [10.3390/pharmaceutics11030107] |
| 4. Yanni Tai, Mintong Zhao, Feng Ding, Gelin Wu, Haibin Qu, Ping Gong, Yongjian Xie, Peng Zhou, Xingchu Gong. (2024) Analytical quality by design based on knowledge organization: A case study of developing an ultrahigh-performance liquid chromatography method for the detection of phenolic compounds. PHYTOCHEMICAL ANALYSIS, [PMID:38462508] [10.1002/pca.3343] |