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紫草素
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S424442-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | (±)-Alkannin | (±)-Shikalkin | (±)-Shikonin | (±)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone |
|---|---|
| 英文别名 | 5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione | Shikonin S | (+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone | 2-(2-methoxyethoxyl)ethyl 4-methylbenzenesulfonate | shikonin | (R)-5,8-Dihydroxy-2-(1-hydro |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Shikonin |
| 生化机理 | 石蒜素是一种天然活性化学物质，存在于石蒜的根部，是一种中草药。该化合物是一种萘醌衍生物，已被证明具有抗炎和抗肿瘤特性，并能改变趋化因子的表达和功能。血管生成研究表明，石蒜素能抑制血管内皮细胞的增殖和迁移，阻断整合素 αvβ3 的表达，并能抑制 B16 黑色素瘤和肿瘤坏死因子-α 诱导的小鼠血管生成。在艾滋病毒研究中，Shikonin 可下调巨噬细胞中主要 HIV-1 核心受体 CKR-5 （CCR5）的蛋白和 mRNA 表达。Shikonin 是 PKM2 的抑制剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
A naphthoquinone derivative with angiogenesis inhibitor properties. A naphthoquinone derivative with angiogenesis inhibitor properties. |
关联靶点（人）
CDC25A
Tchem
M 期诱导剂磷酸酶 1(M-phase inducer phosphatase 1)
(1 活性数据)
CDC25B
Tchem
M 期诱导剂磷酸酶 2(M-phase inducer phosphatase 2)
(1 活性数据)
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione |
| INCHI | 1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1 |
| InChi Key | NEZONWMXZKDMKF-SNVBAGLBSA-N |
| Smiles | CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C |
| Isomeric SMILES | CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C |
| PubChem CID | 479503 |
| 分子量 | 288.30 |
化学和物理性质
| 分子量 | 288.290 g/mol |
|---|---|
| XLogP3 | 3.000 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 288.1 Da |
| 单同位素质量Monoisotopic Mass | 288.1 Da |
| 拓扑极表面积Topological Polar Surface Area | 94.800 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 501.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H412: 对水生生物有害并具有长期持续影响 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P301+P312+P330: 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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此产品的引用文献
引用文献
| 1. Chen Xiaohui, Lin Shengrong, Liang Yunbang, Xue Xiaomin, Yasen Miersalijiang. (2023) Experimental evidence of shikonin as a novel intervention for anti-inflammatory effects. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, (1-11). [PMID:37249613] [10.1007/s00210-023-02542-1] |
| 2. Wenjie Feng, Wanrui Shi, Ze Wang, Yanqi Cui, Xinxin Shao, Shuwei Liu, Li Rong, Yi Liu, Hao Zhang. (2022) Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification. ACS Applied Materials & Interfaces, 14 (33): (37540–37552). [PMID:35944147] [10.1021/acsami.2c11130] |
| 3. Yang Chen, Leting Si, Jinghui Zhang, Hengyuan Yu, Xuesong Liu, Yong Chen, Yongjiang Wu. (2021) Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis. PHYTOMEDICINE, 82 (153460). [PMID:33476976] [10.1016/j.phymed.2021.153460] |
| 4. Yang Chen, Juan Ni, Yun Gao, Jinghui Zhang, Xuesong Liu, Yong Chen, Zhongjian Chen, Yongjiang Wu. (2020) Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying Shikonin on colon cancer patient-derived xenograft model.. Scientific Reports, 10 (1): (14092-14092). [PMID:32839531] [10.1038/s41598-020-71116-5] |
| 5. Hongli Guo, Jieyu Sun, Deyi Li, Yahui Hu, Xiaowen Yu, Hu Hua, Xia Jing, Feng Chen, Zhanjun Jia, Jing Xu. (2019) Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. BIOMEDICINE & PHARMACOTHERAPY, 112 (108704). [PMID:30818140] [10.1016/j.biopha.2019.108704] |
| 6. Yali Zhang, Tingting Xu, Zheer Pan, Xiangting Ge, Chuchu Sun, Chun Lu, Hongjin Chen, Zhongxiang Xiao, Bing Zhang, Yuanrong Dai, Guang Liang. (2018) Shikonin inhibits myeloid differentiation protein 2 to prevent LPS-induced acute lung injury. BRITISH JOURNAL OF PHARMACOLOGY, 175 (5): (840-854). [PMID:29243243] [10.1111/bph.14129] |
| 7. Wang Rong, Zhu Liangqin, Wang Jianfei, Zeng Chenglong, Chen Ying, Wei Yan. (2025) Electrochemical sensing interface of copper-coordinated polyhistidine/functionalized multi-walled carbon nanotubes for shikonin determination. JOURNAL OF SOLID STATE ELECTROCHEMISTRY, (1-14). [10.1007/s10008-025-06244-x] |
| 8. Zhiyuan Liu, Yaxuan Huang, Rui Sun, Nan Li, Fengyun Xu, Wei Zhang, Wenke Zhang. (2025) Polyethylene Glycolated Shikonin-Functionalized Carbon Nanotubes as an Effective Anticancer System Combining Chemotherapy and Photothermal Therapy. LANGMUIR, [PMID:40015981] [10.1021/acs.langmuir.4c05257] |
| 9. Shaoyi Cao, Huaqiu Li, Xiaoyan Ye, Xinxing Xing, Yonghuan Xie, Xiangfeng Zeng, Hongjiao Liu, Xing Zhong, Xinyi Yang, Wenxiu Xing, Cairong Zhu, Xiaoping Wu. (2024) Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 29 (611). [PMID:39702296] [10.1186/s40001-024-02187-7] |