| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S422828-1ml |
1ml |
现货  |
|
| 别名 | 血根碱 | 假白屈菜季铵碱 |
|---|---|
| 英文别名 | CHEBI:17183 | sangvinarin | AB00053789_04 | compound 1 [PMID: 28621943] | BDBM25525 | NCGC00015959-04 | 13-Methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium nitrate | NCGC00015959-03 | UI5 | Benzophenanthridine alkaloid | Q-100313 | SCHEMB |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Sanguinarine |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | G 蛋白信号调节抑制剂 17 |
| 产品介绍 |
血根碱是一种来源于 Sanguinaria Canadensis 的生物碱，可通过激活活性氧 (ROS) 的产生来刺激细胞凋亡。Sanguinarine 诱导的细胞凋亡与 JNK 和 NF-κB 的活化有关。 Product Describtion: Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation. |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene |
| INCHI | 1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1 |
| InChi Key | INVGWHRKADIJHF-UHFFFAOYSA-N |
| Smiles | C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6 |
| Isomeric SMILES | C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6 |
| PubChem CID | 5154 |
| 分子量 | 332.33 |
| 分子量 | 332.300 g/mol |
|---|---|
| XLogP3 | 4.400 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 332.092 Da |
| 单同位素质量Monoisotopic Mass | 332.092 Da |
| 拓扑极表面积Topological Polar Surface Area | 40.800 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 1 |
| 复杂度Complexity | 530.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Xiang Zhou, Haojie Ye, Xiuhui Gao, Yumei Feng, Wubin Shao, Puying Qi, Zhibing Wu, Liwei Liu, Peiyi Wang, Song Yang. (2021) The discovery of natural 4'-demethylepipodophyllotoxin from renewable Dysosma versipellis species as a novel bacterial cell division inhibitor for controlling intractable diseases in rice. INDUSTRIAL CROPS AND PRODUCTS, 174 (114182). [10.1016/j.indcrop.2021.114182] |
| 2. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [10.1039/D0NJ01197E] |
| 3. Yingzhi Hu, Huaidong Peng, Youshao Yan, Shuyu Guan, Shumei Wang, Paul C.H. Li, Yue Sun. (2017) Integration of laminar flow extraction and capillary electrophoretic separation in one microfluidic chip for detection of plant alkaloids in blood samples. ANALYTICA CHIMICA ACTA, 985 (121). [PMID:28864182] [10.1016/j.aca.2017.05.036] |
| 4. Ting Tan, Mingliang Zhang, Yiqun Wan, Hongdeng Qiu. (2016) Utilization of deep eutectic solvents as novel mobile phase additives for improving the separation of bioactive quaternary alkaloids. TALANTA, 149 (85). [PMID:26717817] [10.1016/j.talanta.2015.11.041] |
| 5. Yue Sun, Yuanyuan Li, Jiajian Zeng, Qixian Lu, Paul C.H. Li. (2015) Microchip electrophoretic separation and fluorescence detection of chelerythrine and sanguinarine in medicinal plants. TALANTA, 142 (90). [PMID:26003696] [10.1016/j.talanta.2015.04.008] |
| 6. Jing Zhu, Qing Hong Zhang, Wen Wu Wang. (2024) Pattern Recognition of Alkaloids by Inhibiting the Catalytic Activity of Dopzymes for Dopamine. ANALYTICAL CHEMISTRY, 96 (30): (12424-12432). [PMID:39014901] [10.1021/acs.analchem.4c01920] |
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