| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S422809-1ml |
1ml |
现货  |
|
| 英文别名 | solifenacine | A16947 | Solifenacin (INN) | SCHEMBL9971260 | Solifenacina | (3R)-1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate | AKOS015896445 | (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl-3,4-dihydro-1-phenyl-2(1H)-is |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Solifenacin (YM905) |
| 生化机理 | 索利那新（YM905）是一种竞争性毒蕈碱受体拮抗剂。乙酰胆碱与这些受体（尤其是 M3 受体亚型）的结合在平滑肌的收缩中起着至关重要的作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | M 1 受体拮抗剂；M 2 受体拮抗剂；M 3 受体拮抗剂；M 4 受体拮抗剂；M 5 受体拮抗剂 |
| 产品介绍 |
Information Solifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. |
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate |
| INCHI | 1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1 |
| InChi Key | FBOUYBDGKBSUES-VXKWHMMOSA-N |
| Smiles | C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5 |
| Isomeric SMILES | C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5 |
| PubChem CID | 154059 |
| 分子量 | 362.48 |
| 分子量 | 362.500 g/mol |
|---|---|
| XLogP3 | 4.000 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 362.199 Da |
| 单同位素质量Monoisotopic Mass | 362.199 Da |
| 拓扑极表面积Topological Polar Surface Area | 32.800 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 524.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Huang Xiaomin, Wang Ting, Wang Ludan, Sun Yantao, Zhang Ziru, Zhang Yajun. (2024) Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products. BMC Chemistry, 18 (1): (1-15). [PMID:38702791] [10.1186/s13065-024-01198-z] |
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