| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S422238-1ml |
1ml |
现货  |
|
| 英文别名 | Propanamide,2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]-,(2S)- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | SGC2085 |
| 生化机理 | SGC2085 是一种强效的选择性辅激活剂相关精氨酸甲基转移酶 1 (CARM1) 抑制剂，其 IC50 值为 50 nM，与其他 PRMTs 相比，选择性大于 100 倍。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 辅助激活剂相关精氨酸甲基转移酶 1 抑制剂 |
| 产品介绍 |
Information SGC2085 SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs. Targets CARM1 (Cell-free assay) 50 nM In vitro With the exception of PRMT6 (IC50 = 5.2 μM), SGC2085 does not inhibit other PRMTs. Although CARM1(PRMT4) is previously shown to asymmetrically dimethylate BAF155 at R1064, no cellular activity is observed for SGC2085 when tested up to 10 μM. The absence of cellular activity for SGC2085 may due to poor permeability. Cell Research(from reference) Cell lines：HEK293 cells Concentrations：up to 10 μM Incubation Time：48 h |
| ALogP | 3.498 |
|---|---|
| HBD Count | 2 |
| Rotatable Bond | 5 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 未知 |
|---|---|
| IIUPAC Name | (2S)-2-amino-N-[[4-(3,5-dimethylphenoxy)-3-methylphenyl]methyl]propanamide |
| INCHI | 1S/C19H24N2O2/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20/h5-10,15H,11,20H2,1-4H3,(H,21,22)/t15-/m0/s1 |
| InChi Key | GLFOFXKMALJTCZ-HNNXBMFYSA-N |
| Smiles | CC1=CC(=CC(=C1)OC2=C(C=C(C=C2)CNC(=O)C(C)N)C)C |
| Isomeric SMILES | CC1=CC(=CC(=C1)OC2=C(C=C(C=C2)CNC(=O)[C@H](C)N)C)C |
| 关联CAS | 1821908-49-9 |
| PubChem CID | 121231417 |
| 分子量 | 312.41 |
| DMSO(mg / mL) Max Solubility | 62 |
|---|---|
| DMSO(mM) Max Solubility | 198.4571557 |
| Water(mg / mL) Max Solubility | ＜1 |
| 分子量 | 312.400 g/mol |
| XLogP3 | 3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 312.184 Da |
| 单同位素质量Monoisotopic Mass | 312.184 Da |
| 拓扑极表面积Topological Polar Surface Area | 64.400 Ų |
| 重原子数Heavy Atom Count | 23 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 378.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 |
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