| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S421489-1ml |
1ml |
期货  |
|
| 别名 | 西地那非 | 西地那非 |
|---|---|
| 英文别名 | SMR004703325 | Sildenafil- Bio-X | DTXCID003579 | G04BE03 | HSDB 7305 | Spectrum3_001892 | UK-92480 | sildenafilum | SpecPlus_000798 | UNII-3M7OB98Y7H | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRI |
| 规格或纯度 | Moligand™, 10mM in Water |
| 英文名称 | Sildenafil |
| 生化机理 | 西地那非是 5 型 cGMP 磷酸二酯酶（PDE5 抑制剂）的选择性抑制剂，该酶催化 3',5'-环鸟苷单磷酸（cGMP）的水解。据报道，作为一种 PDE5 抑制剂，西地那非能增强中风大鼠模型的神经、突触和血管生成，同时也是一种温和的血管扩张剂。西地那非还能通过 NO/cGMP 依赖性机制防止吲哚美辛诱发的小肠溃疡形成。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | ABCC5 抑制剂;OATP1B3 抑制剂;OATP2B1 抑制剂;磷酸二酯酶 5A 抑制剂;磷酸二酯酶 6C 抑制剂 |
| 产品介绍 |
Sildenafil是磷酸二酯酶5（PDE-5）抑制剂，IC50为5.22 nM，可能是最好的可作用于勃起功能紊乱的化合物。 Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one |
| INCHI | 1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) |
| InChi Key | BNRNXUUZRGQAQC-UHFFFAOYSA-N |
| Smiles | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C |
| Isomeric SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C |
| PubChem CID | 135398744 |
| 分子量 | 474.58 |
| 分子量 | 474.600 g/mol |
|---|---|
| XLogP3 | 1.500 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 474.205 Da |
| 单同位素质量Monoisotopic Mass | 474.205 Da |
| 拓扑极表面积Topological Polar Surface Area | 118.000 Ų |
| 重原子数Heavy Atom Count | 33 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 838.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H319: 引起严重眼睛刺激 H412: 对水生生物有害并具有长期持续影响 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P330: 漱口 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| 1. Yang Yi-Ting, Yan Bin, Li Yu-Hua, Guo Li-Na, Wang Wei-Wei, Liu Li-Jie, Yu He-Guo, Diao Hua. (2023) Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility. ASIAN JOURNAL OF ANDROLOGY, (10.4103/aja2022117). [PMID:37026191] [10.4103/aja2022117] |
| 2. Kun Liu, Xiaohan Zhang, Xiongfeng Zhou, Xinming Huo, Xiaohao Wang, Kostya (Ken) Ostrikov. (2022) Experimental investigation of an atmospheric pressure plasma jet as an ion source for on-site mass-spectrometry analysis of nonvolatile solid samples: the integration effect of thermal desorption and ionization. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 55 (48): (485202). [10.1088/1361-6463/ac968a] |
| 3. Hao Gu, Kang Ma, Weiqian Zhao, Lirong Qiu, Wei Xu. (2021) A general purpose MALDI matrix for the analyses of small organic, peptide and protein molecules. ANALYST, 146 (12): (4080-4086). [PMID:34052846] [10.1039/D1AN00474C] |
| 4. Ting-Ting ZOU, Jin-Yi YANG, Zhen-Lin XU, Hong WANG, Yuan-Ming SUN, Hong-Tao LEI, Xue-Cai TAN, Yu-Dong SHEN. (2019) Detection of Tadalafil and Its Analogues in Health Wine and Oral Liquid by Microwell Lateral Flow Immunochromatography Assay. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 47 (1249). [10.1016/S1872-2040(19)61182-5] |
| 5. Tian Wei, Yongyi Zhang, Jianxin Huang, Jinyi Yang, Yuanxin Tian, Yudong Shen. (2024) Rapid detection of multiple sildenafil and tadalafil adulterants in dietary supplements by dual-labeled probe time-resolved fluorescence immunochromatography assay. Food Bioscience, 59 (103905). [10.1016/j.fbio.2024.103905] |
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