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亚精胺, K ir2.1 通道阻断剂；K ir2.3 通道阻断剂

42篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
S416439-1g
 1g 现货 Stock Image
S416439-5g
 5g 现货 Stock Image
S416439-25g
 25g 现货 Stock Image
S416439-100g
 100g 现货 Stock Image
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Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) 代谢物 (8911)
main product photo

基本描述

别名 精脒 | N-(3-氨基丙基)-1,4-丁烷 | 1,8-二氨基-4-氮杂辛烷
英文别名 N-(3-Aminopropyl)-1,4-diamino-butane | SPERMIDINE [MI] | KBio2_005481 | SPERMIDINE [INCI] | bmse000116 | KBio1_001007 | SDCCGMLS-0066822.P001 | KBioGR_001542 | NCGC00024903-01 | bmse000951 | DTXSID4036645 | 1122077-27-3 | BDBM50009353 | D95527 | N-(4-Amin
规格或纯度 Moligand™, ≥97%
英文名称 Spermidine
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
作用类型 通道阻滞剂
作用机制 K ir2.1 通道阻断剂；K ir2.3 通道阻断剂
产品介绍

应用

抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。
纯度 ≥97%

关联靶点（人）

KCNJ4 Tchem 内向整流钾通道4(Inward rectifier potassium channel 4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
KCNJ2 Tchem 内向整流钾通道2(Inward rectifier potassium channel 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA4 Tclin 碳酸酐酶4(Carbonic anhydrase 4) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA14 Tclin 碳酸酐酶14(Carbonic anhydrase 14) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TOP2A Tclin DNA topoisomerase II alpha (6317 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ODC1 Tclin Ornithine decarboxylase (70 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA3 Tclin Carbonic anhydrase III (753 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PAOX Tchem Polyamine oxidase (84 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA5B Tclin Carbonic anhydrase VB (957 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA5A Tclin Carbonic anhydrase VA (1168 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AMD1 Tchem S-adenosylmethionine decarboxylase 1 (215 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-937 (7138 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
T47D (39041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HeLa (62764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
F13A1 Tchem Coagulation factor XIII (223 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC22A1 Tchem Solute carrier family 22 member 1 (646 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THPO Tbio Thrombopoietin (834 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE1A Tclin Phosphodiesterase 1 (671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Ca7 Carbonic anhydrase VII (3 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca13 Carbonic anhydrase XIII (322 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA4 Carbonic anhydrase IV (1713 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Haemophilus influenzae (8812 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus cereus (7522 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHO (4503 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHO-MG (239 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L1210 (27553 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P19 (309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SV3T3 (134 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Calf thymus DNA (4845 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca15 Carbonic anhydrase 15 (173 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus anthracis (2936 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc22a4 Solute carrier family 22 member 4 (11 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sat2 Spermidine/spermine N(1)-acetyltransferase (SAT) (56 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc26a1 Sulfate anion transporter 1 (11 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FL5.12 (351 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 204-689-0
分子类型 小分子
IIUPAC Name N'-(3-aminopropyl)butane-1,4-diamine
INCHI 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChi Key ATHGHQPFGPMSJY-UHFFFAOYSA-N
Smiles NCCCCNCCCN
Isomeric SMILES C(CCNCCCN)CN
UN Number 2735
分子量 145.25
Beilstein号 1698591

化学和物理性质

溶解性 Miscible with water, ethanol and ether.
敏感性 对空气和湿度敏感
折光率 1.4785-1.4805
闪点(℉) 230°F
闪点(℃) >110°
沸点 128-130°C
熔点 22-25°C
分子量 145.250 g/mol
XLogP3 -1.000
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 7
精确质量Exact Mass 145.158 Da
单同位素质量Monoisotopic Mass 145.158 Da
拓扑极表面积Topological Polar Surface Area 64.099 Ų
重原子数Heavy Atom Count 10
形式电荷Formal Charge 0
复杂度Complexity 56.800
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS05
信号词 危险
危险声明

H314: 造成严重的皮肤灼伤和眼睛损伤

H318: 造成严重的眼睛损伤
预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P264: 处理后要彻底洗手。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P363: 再次使用之前，请清洗受污染的衣物。

P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。

P317: 寻求紧急医疗救助。

P302+P361+P354: 如果接触皮肤：立即脱掉所有被污染的衣服。立即用水冲洗几分钟。

P316: 立即寻求紧急医疗救助。
WGK Germany 3
个人防护装备 Faceshields,Gloves,Goggles

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批号(Lot Number) 证书类型 货号
B2307234 分析证书 S416439
G2522094 分析证书 S416439
E2213124 分析证书 S416439
E2213136 分析证书 S416439
E2213137 分析证书 S416439
E2213139 分析证书 S416439
F2316099 分析证书 S416439
L2304046 分析证书 S416439
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B2526053 分析证书 S416439

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4. Zekun Shi, Yongning Wu, Xue Zhang, Yanyan Gao, Luqin Qiao, Qin Hou, Minglin Wang.  (2023)  Highly sensitive and selective colorimetric and fluorescent dual-readout assay for the analysis of spermine, spermidine and cysteine.  DYES AND PIGMENTS,  220  (111659).  [10.1016/j.dyepig.2023.111659]
5. Dongdong Cao, Yutao Huang, Gaofu Mei, Sheng Zhang, Huaping Wu, Tiyuan Zhao.  (2023)  Spermidine enhances chilling tolerance of kale seeds by modulating ROS and phytohormone metabolism.  PLoS One,  18  (8): (e0289563).  [PMID:37535595] [10.1371/journal.pone.0289563]
6. Xiang Gao, Peng Nie, Peiran Li, Zhi Zheng, Jieshun Cheng, Ying Gu, Yizhong Shen.  (2023)  Silver metallization-triggered liposome-embedded AIE fluorophore for dual-mode detection of biogenic amines to fight food freshness fraud.  FOOD CHEMISTRY,  429  (136961).  [PMID:37499507] [10.1016/j.foodchem.2023.136961]
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9. Xu Yanfen, Lu Ying, Yu Jianna, Liu Wen, Jing Guoxing, Li Wenshan, Liu Wenjie.  (2023)  Determination of Seven Biogenic Amines in Tuna with High-Performance Liquid Chromatography Coupled to Electrospray Ionization Ion Mobility Spectrometry.  Food Analytical Methods,  16  (5): (909-917).  [10.1007/s12161-023-02455-y]
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14. Yujuan Qin, Pengcheng Huang, Fang-Ying Wu.  (2022)  Histamine-responsive dye-incorporated carbon dots for visual monitoring of food spoilage.  SENSORS AND ACTUATORS B-CHEMICAL,  365  (131911).  [10.1016/j.snb.2022.131911]
15. Xu Xu, Jiaxin Gao, Di Cao, Xiang Li, Xin Zhao, Shuang Yue, Lei Zhang.  (2022)  Designed 3D N-doped magnetic porous carbon spheres for sensitive monitoring of biogenic amine by simultaneous microwave-assisted derivatization and magnetic-solid phase extraction.  JOURNAL OF CHROMATOGRAPHY A,  1667  (462882).  [PMID:35149412] [10.1016/j.chroma.2022.462882]
16. Xinxiu Ma, Jingran Bi, Xinyu Li, Gongliang Zhang, Hongshun Hao, Hongman Hou.  (2021)  Contribution of Microorganisms to Biogenic Amine Accumulation during Fish Sauce Fermentation and Screening of Novel Starters.  Foods,  10  (11): (2572).  [PMID:34828853] [10.3390/foods10112572]
17. Yongliang Guo, Lili Tian, Jiangming Wu, Yang Wu, Yongmei Liu, Jie Du, Xiaoquan Lu.  (2021)  A Highly Sensitive Electrochemiluminescence Spermine Biosensor Based on Au−Ag Bimetallic Nanoclusters.  ELECTROANALYSIS,  33  (9): (2016-2024).  [10.1002/elan.202100169]
18. Cai Shuyu, Wang Guofu, Xu Hua, Liu Jianxin, Luo Jie, Shen Yi.  (2021)  Exogenous Spermidine Improves Chilling Tolerance in Sweet Corn Seedlings by Regulation on Abscisic Acid, ROS and Ca2+ Pathways.  JOURNAL OF PLANT BIOLOGY,  64  (6): (487-499).  [10.1007/s12374-021-09319-0]
19. Yi-Fang Li, Zheng-Zhong Lin, Cheng-Yi Hong, Zhi-Yong Huang.  (2021)  Histamine detection in fish samples based on indirect competitive ELISA method using iron-cobalt co-doped carbon dots labeled histamine antibody.  FOOD CHEMISTRY,  345  (128812).  [PMID:33601655] [10.1016/j.foodchem.2020.128812]
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