柳氮磺胺吡啶, 质子偶联叶酸转运体抑制剂

NF-κB活化抑制剂；也抑制SXC和叶酸转运蛋白1

27篇引用文献

COA

级别和纯度:

Moligand™

≥98%

CAS编号: 599-79-1
分子式: C₁₈H₁₄N₄O₅S
分子量: 398.39
Beilstein号: 356241
EC号: 209-974-3
MDL号: MFCD00057363
PubChem编号: 5339
PubChem SID: 488179898

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
S129986-5g	5g	现货
S129986-25g	25g	现货
S129986-100g	100g	现货
S129986-500g	500g	期货

查看相关系列

Anti-infection (2804) Antibiotic (2632) Apoptosis (7108) Autophagy (2848) Bacterial (5911) Ferroptosis (624) NF-κB (756) Proton-coupled folate transporter Inhibitor (2)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本描述

别名	柳氮磺吡啶 \| 柳氮磺胺吡啶 \| 5-[4-(2-吡啶胺磺酰基)苯偶氮基]水杨酸 \| 2-羟基-5- { { 4-[(2-吡啶氨基)磺酰基]苯基}偶氮}苯甲酸 \| 5-[对-(2-吡啶胺磺酰基)苯]偶氮水杨酸
英文别名	5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid \| Sulphasalazine \| BSPBio_002888 \| NSC203730 \| NSC-203730 \| DTXCID401256 \| Iwata \| NSC 203730 \| Benzosulfa \| Sulfasalazina \| sulfasalazine \| w-t Sasp oral \| 2-hydroxy-5-[(E)-{4-[(pyridin-2-ylamino)
规格或纯度	Moligand™, ≥98%
英文名称	Sulfasalazine
生化机理	NF-κB活化抑制剂。抑制人胰腺癌细胞系MIA PaCa-2和PANC-1的体外生长，并诱导胶质母细胞瘤细胞系凋亡。还抑制胱氨酸-谷氨酸反转运蛋白系统Xc（SXC）。叶酸转运蛋白1的抑制剂（SLC19A1）; 抑制细胞吸收甲氨蝶呤和环状二核苷酸，包括2'，3'-cGAMP。消炎药。引起肥大病。
应用	An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
作用机制	质子偶联叶酸转运体抑制剂
产品介绍	Sulfasalazine 是一种磺胺剂，是Mesalazine的衍生物，主要用作抗炎剂。An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer Sulfasalazine is a sulfa agent and a derivative of mesalazine used primarily as an anti-inflammatory agent. An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer
纯度	≥98%

关联靶点（人）

SLC46A1 Tchem 质子偶联叶酸转运体(Proton-coupled folate transporter) (1 活性数据)

点击查看靶蛋白信息： SLC46A1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

PubChem SID	488179898
EC号	209-974-3
IIUPAC Name	2-hydroxy-5-[[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl]benzoic acid
INCHI	1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)
InChi Key	NCEXYHBECQHGNR-UHFFFAOYSA-N
Smiles	C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
Isomeric SMILES	C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
PubChem CID	5339
分子量	398.39
Beilstein号	356241
Reaxy-Rn	356241

化学和物理性质

溶解性	溶于DMSO, 最高浓度 (mg/mL): 39.84, 最高浓度(mM): 100
敏感性	对光敏感
熔点	260-265°C
分子量	398.400 g/mol
XLogP3	-0.700
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	9
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	398.068 Da
单同位素质量Monoisotopic Mass	398.068 Da
拓扑极表面积Topological Polar Surface Area	150.000 Å²
重原子数Heavy Atom Count	28
形式电荷Formal Charge	0
复杂度Complexity	657.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07, GHS08
信号词	危险
危险声明	H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H360: 可能损害生育力或未出生的孩子
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良，请佩戴呼吸防护装置。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P342+P316: 如果出现呼吸道症状：立即寻求急救。
WGK Germany	2
RTECS	VO6250000
Merck Index	8942
个人防护装备	dust mask type N95 (US), Eyeshields, Faceshields, Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到17个结果

批号(Lot Number)	证书类型	货号
H2301810	分析证书	S129986
H2301815	分析证书	S129986
H2301844	分析证书	S129986
H2301845	分析证书	S129986
H2301853	分析证书	S129986
B2512074	分析证书	S129986
J2212309	分析证书	S129986
I2429025	分析证书	S129986
A2509061	分析证书	S129986
H2301802	分析证书	S129986
H2301820	分析证书	S129986
G2114303	分析证书	S129986
G1908031	分析证书	S129986
J2212276	分析证书	S129986
J2212277	分析证书	S129986
J2212278	分析证书	S129986
F2327412	分析证书	S129986

显示更多⌵

可替换产品

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Mushtaq S, Sarkar R. (2020) Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential.. Int J Womens Dermatol, 6 (3): (191-198). [PMID:32637543]
2. Kussmann M, Obermueller M, Spettel K, Winkler S, Aletaha D. (2021) In vitro evaluation of disease-modifying antirheumatic drugs against rheumatoid arthritis associated pathogens of the oral microflora.. RMD Open, 7 (3): [PMID:34588273]
3. Ke Ning, Chao Shi, Yan-Yu Chi, Yong-Fei Zhou, Weiwei Zheng, Yameng Duan, Weiwei Tong, Qiuhong Xie, Hongyu Xiang. (2024) Portulaca oleracea L. polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal homeostasis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 256 (128375). [PMID:38000581] [10.1016/j.ijbiomac.2023.128375]
4. Yiren Yang, Yuwei Zhang, Jiangping Song, Yaqian Li, Liuyang Zhou, Hongtao Xu, Kaizhang Wu, Jie Gao, Mouming Zhao, Yang Zheng. (2023) Bergamot polysaccharides relieve DSS-induced ulcerative colitis via regulating the gut microbiota and metabolites. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (127335). [PMID:37820919] [10.1016/j.ijbiomac.2023.127335]
5. Xiaoxun Lu, Jiabin Hong, Jing Zhang, Qian Liu, Ganzhong Liao, Yanwei Shi, Huanwen Tang, Xiaoshan Liu. (2023) Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. SCIENCE OF THE TOTAL ENVIRONMENT, (166688). [PMID:37659542] [10.1016/j.scitotenv.2023.166688]
6. Yajing Wang, Tao Zhang, Jie Liu, Xianfeng Huang, Xiaojing Yan. (2023) Investigations of the gingerol oil colon targeting pellets for the treatment of ulcerative colitis. FITOTERAPIA, 169 (105607). [PMID:37442485] [10.1016/j.fitote.2023.105607]
7. Ke Ning, Yameng Duan, Weiwei Tong, Yue Chen, Qinghui Zhang, Qiuhong Xie, Hongyu Xiang. (2023) Protective Effects of Different Molecular Weights of Purslane (Portulaca oleracea L.) Aqueous Extract on DSS-Induced Ulcerative Colitis in Mice. Antioxidants, 12 (7): (1400). [PMID:37507939] [10.3390/antiox12071400]
8. Chunhong Wu, Yifei Xiao, Caimei Wu, Dihao Xie, Meixue Luo, Dingyi Yao, Min Chen, Danyi Lu. (2023) Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα. XENOBIOTICA, 53 (3): (215-222). [PMID:37039301] [10.1080/00498254.2023.2200839]
9. Wang Li, Shao Li, Chen Man-Yun, Wang Lin, Zhang Wei, Tan Feng-Bo, Huang Wei-Hua. (2022) Effect of ginsenoside compound K on alleviating colitis via modulating gut microbiota. Chinese Medicine, 17 (1): (1-12). [PMID:36578000] [10.1186/s13020-022-00701-9]
10. Li Wang, Li Shao, Man-Yun Chen, Lin Wang, Pu Yang, Feng-Bo Tan, Wei Zhang, Wei-Hua Huang. (2022) Panax notoginseng Alleviates Colitis via the Regulation of Gut Microbiota. AMERICAN JOURNAL OF CHINESE MEDICINE, 51 (1): (107-127). [PMID:36408726] [10.1142/S0192415X23500076]
11. Xiaomeng Tang, Meng Yang, Yongwei Gu, Liangdi Jiang, Yue Du, Jiyong Liu. (2022) Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis. Drug Design Development and Therapy, [PMID:34616144] [10.2147/DDDT.S322702]
12. Yuanfang Kong, Yulong Hu, Jieming Li, Juntao Cai, Yuanhao Qiu, Chunhong Dong. (2022) Anti-inflammatory Effect of a Novel Pectin Polysaccharide From Rubus chingii Hu on Colitis Mice. Frontiers in Nutrition, 9 (868657). [PMID:35571944] [10.3389/fnut.2022.868657]
13. Jieru Han, Wenhao Li, Guangyu Shi, Yunlei Huang, Xutao Sun, Na Sun, Deyou Jiang. (2022) Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1α. MEDIATORS OF INFLAMMATION, 2022 (9129984). [PMID:35431653] [10.1155/2022/9129984]
14. Hui Chen, Han Zhang, Lixing Cao, Jinling Cui, Xuan Ma, Chong Zhao, Shutao Yin, Hongbo Hu. (2022) Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse. Cancers, 14 (2): (345). [PMID:35053507] [10.3390/cancers14020345]
15. Jingjing Li, Suiyuan Ren, Meng Li, Jingai Bi, Guang Yang, Erguang Li. (2021) Paeoniflorin protects against dextran sulfate sodium (DSS)-induced colitis in mice through inhibition of inflammation and eosinophil infiltration. INTERNATIONAL IMMUNOPHARMACOLOGY, 97 (107667). [PMID:33887576] [10.1016/j.intimp.2021.107667]
16. Yajie Cai, Bing Xu, Fei Zhou, Jianzhi Wu, Shuo Li, Qi Zheng, Yajing Li, Xiaojiaoyang Li, Feng Gao, Shifen Dong, Runping Liu. (2021) Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation. PHYTOMEDICINE, 84 (153495). [PMID:33611210] [10.1016/j.phymed.2021.153495]
17. Longfa Kou, Rui Sun, Shuyi Xiao, Yawen Zheng, Zhiwei Chen, Aimin Cai, Hailun Zheng, Qing Yao, Vadivel Ganapathy, Ruijie Chen. (2019) Ambidextrous Approach To Disrupt Redox Balance in Tumor Cells with Increased ROS Production and Decreased GSH Synthesis for Cancer Therapy. ACS Applied Materials & Interfaces, 11 (30): (26722–26730). [PMID:31276364] [10.1021/acsami.9b09784]
18. Yan Liu, Wenji Kang, Libo Nie, Fen Xiao, Yilong Li, Qinbin Ma, Danqi Lin, Guiyin Zhou, Sihua Liu, Kehui Sun, Xiangqian Li. (2024) Alginate/methacrylic acid/calcium ion-based pH-sensitive drug delivery hydrogel for the treatment of ulcerative colitis. REACTIVE & FUNCTIONAL POLYMERS, 204 (106025). [10.1016/j.reactfunctpolym.2024.106025]
19. Yueqi Hu, Li Zhou, Jian Yang, Ruibin Bai, Eric Marchioni, Minjie Zhao, Li Zhou. (2024) Anti-inflammatory mechanism of Houttuynia cordata polysaccharides against ulcerative colitis based on multi-omics conjoint analysis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (137311). [PMID:39521219] [10.1016/j.ijbiomac.2024.137311]
20. Guangshuai Zhang, Dandan Song, Ruilong Ma, Mo Li, Bingyang Liu, Zhonggui He, Qiang Fu. (2024) Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease. Science Advances, 10 (30): [PMID:39058786] [10.1126/sciadv.ado8222]
21. Shuang Li, Bingjie Wang, Jiaojiao Tao, Yu Dong, Teng Wang, Xia Zhao, Tianze Jiang, Lianxiao Zhang, Hai Yang. (2024) Chemodynamic therapy combined with endogenous ferroptosis based on “sea urchin-like” copper sulfide hydrogel for enhancing anti-tumor efficacy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 660 (124330). [PMID:38866081] [10.1016/j.ijpharm.2024.124330]
22. Mengru Bai, Qian Shen, Yong Wu, Zhiyuan Ma, Yuqing Wang, Mingyang Chen, Dan Liu, Lin Zhou. (2024) Evaluation of transport mechanisms of methotrexate in human choriocarcinoma cell lines by LC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 247 (116268). [PMID:38823222] [10.1016/j.jpba.2024.116268]
23. Jingwen Guo, Yuanzhi He, Jiaqi Li, Min Lin, Yihan Wu, Jiayi Yang, Zehui He, Long Meng, Zhi Wang, Qing Xia, Chunyun Zhu, Yongtai Zhang, Nianping Feng. (2025) In Situ Hydrogel Transformed from Dicarboxylic Anhydride-Cross-Linked Cyclodextrin Nanosponge-Encapsulated Parthenolide Restored the Intestinal Mucosal Barrier of Ulcerative Colitis. ACS Applied Materials & Interfaces, 17 (12): (18003-18021). [PMID:40096675] [10.1021/acsami.4c21687]
24. Lian Xu, Yan Xiao, Kun Yu, Hongshuo Pan, Jiayi Xu, Yiyun Guan, Mengke Wang, Xiangyu Xu, Hao Wang. (2025) Machine Learning-Assisted Chemical Tongues Based on Dual-channel Inclusion Complexes for Rapid Identification of Nonsteroidal Anti-inflammatory Drugs in Food. ACS Sensors, [PMID:39992799] [10.1021/acssensors.4c02806]
25. Cong Yuan, Xiaoxiao Zhu, Jiaqi Pan, Minghao Xu, Yongjun Jiang, Sheng Dai, Yikai Huang, Leixi Lu, Lei Zhou, Chengcheng Tian. (2024) Mechanical insight into direct singlet oxygen generation pathway: The significance of Co-O-X bond formation anchored by cobalt single atoms on mesoporous oxides. CHEMICAL ENGINEERING JOURNAL, 484 (149364). [10.1016/j.cej.2024.149364]
26. Tingting Chen, Gaoxiang Ai, Guihong Liang, Lingfeng Zeng, Di Zhao, Jun Liu, Yaoxing Dou. (2024) Mitigation of inflammatory bowel disease-related osteoporosis by oxyberberine: Insights into the RANKL/NF-κB signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 174 (116523). [PMID:38574627] [10.1016/j.biopha.2024.116523]
27. Heung Lam MOK, Ka Wing CHENG, Yiqi XU, Chunhua HUANG, Cheng LYU, Jiaruo XU, Die HU, Lin ZHU, Chengyuan LIN, Hor-Yue TAN, Zhaoxiang BIAN. (2024) Modified Zhenwu Decoction suppresses chronic colitis via targeting macrophage CCR2/Fyn/p38 MAPK signaling axis. PHYTOMEDICINE, (155694). [PMID:38733904] [10.1016/j.phymed.2024.155694]
28. Yuzhen Kang, Dongyu Wu, Tiantian Zhang, Yue Zhang, Yan Zhong, Shiqi Chen, Xiaoyu Wang, Xuyu Chai. (2025) Synthesis and characterization of Poly(N-Acryloyl 6-aminocaproic acid) for intestine-specific drug delivery. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 107 (106760). [10.1016/j.jddst.2025.106760]
29. Chunhua Huang, Cheng Lyu, Heung-Lam Mok, Yiqi Xu, Ka-Wing Cheng, Cheng Zhang, Die Hu, Lin Zhu, Chengyuan Lin, Xin Chen, Hor-Yue Tan, Zhaoxiang Bian. (2024) Tolerogenic dendritic cell-mediated regulatory T cell differentiation by Chinese herbal formulation attenuates colitis progression. Journal of Advanced Research, [PMID:38677546] [10.1016/j.jare.2024.04.023]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度