This is a demo store. No orders will be fulfilled.

首页   400-620-6333
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
高级搜索
菜单
登录
设置
྾

SB431542,ALK抑制剂, 激活素 A 受体 1C 型抑制剂；转化生长因子 beta 受体 1 抑制剂

ALK抑制剂
3篇引用文献 COA COA
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
S125924-10mg
 10mg 期货 Stock Image
S125924-50mg
 50mg 现货 Stock Image
S125924-100mg
 100mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
activin A receptor type 1C Inhibitor (1) Apoptosis (7108) TGF-beta/Smad (305) TGF-β Receptor (70) transforming growth factor beta receptor 1 Inhibitor (14) 受体酪氨酸激酶(RTK)抑制剂 (18)
main product photo

基本描述

别名 4-[4-(1,3-苯并二氧戊环-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺 | 4-4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基-苯甲酰胺 | 4-(5-苯并1,3二唑-5-基-4-吡啶-2-基-1H-咪唑-2-基)-苯甲酰胺 | 4-4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基-苯甲酰胺
英文别名 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide | 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE | SB431542 | SB-431542 | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide | SB 431542
规格或纯度 Moligand™, ≥98%
英文名称 SB431542
生化机理 SB 431542 是一种小分子，是 TGFβ RI、ACTR-IB 和 ACTR-IC（转化生长因子-β 超家族 I 型活化素受体样激酶（ALK）受体 ALK4、5 和 7）的特异性和选择性抑制剂。肾癌研究表明，SB 431542 是 Smad3 磷酸化（IC50= 94nM）和 TGF-β-1 胶原诱导的 lα1 （col Iα1）的选择性抑制剂。据报道，SB 431542 不会影响 JNK、ERK 或 p38 MAP 激酶通路。SB 431542 可抑制 TGF-β 诱导的 MG63 细胞生长刺激，抑制胶质瘤细胞的运动和增殖，阻断 SMAD 的磷酸化和转位。抑制 ALK 4、5（IC 50 = 94 nM）和 7。也可以固体形式提供。
储存温度 避光,-20°C储存
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 激活素 A 受体 1C 型抑制剂；转化生长因子 beta 受体 1 抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

SB431542是一种有效的，选择性的ALK5抑制剂，IC50为94 nM，对ALK5的作用比对p38、 MAPK和其他激酶强100倍。A specific and selective inhibitor of TGF-β type I ALK receptors and Smad3.

SB-431542被用于研究结直肠肿瘤细胞中血小板衍生生长因子受体B表达与TGF-β途径激活的相关性。它被用于研究TGF-β信号传导在调节细胞外基质 和成肌细胞分化中的作用。

SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
A specific and selective inhibitor of TGF-β type I ALK receptors and Smad3.
纯度 ≥98%

关联靶点（人）

TGFBR1 Tchem TGF-β受体1型(TGF-beta receptor type-1) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ACVR1C Tbio 激活素受体 1C 型(Activin receptor type-1C) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IGF1R Tclin Insulin-like growth factor I receptor (8605 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KIT Tclin Stem cell growth factor receptor (10667 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TUBA4A Tchem Tubulin alpha-1 chain (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSNK2A1 Tchem Casein kinase II alpha (3512 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DAPK3 Tchem Death-associated protein kinase 3 (2108 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAPK11 Tchem MAP kinase p38 beta (2785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LCK Tclin Tyrosine-protein kinase LCK (9212 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAPK14 Tchem MAP kinase p38 alpha (12866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PRKACB Tchem cAMP-dependent protein kinase beta-1 catalytic subunit (589 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAP2K6 Tchem Dual specificity mitogen-activated protein kinase kinase 6 (1284 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MYLK Tchem Myosin light chain kinase, smooth muscle (1267 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSNK1G1 Tchem Casein kinase I gamma 1 (2496 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FGFR2 Tclin Fibroblast growth factor receptor 2 (3405 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
STK3 Tchem Serine/threonine-protein kinase MST2 (3069 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CAMK2B Tchem CaM kinase II beta (1626 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAP2K3 Tchem Dual specificity mitogen-activated protein kinase kinase 3 (632 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PRKAA2 Tchem AMP-activated protein kinase, alpha-2 subunit (1328 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKT3 Tchem Serine/threonine-protein kinase AKT3 (3157 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DAPK2 Tchem Death-associated protein kinase 2 (740 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RPS6KA4 Tchem Ribosomal protein S6 kinase alpha 4 (2104 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ROCK1 Tclin Rho-associated protein kinase 1 (4723 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PKN2 Tchem Protein kinase N2 (1991 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSK Tchem Tyrosine-protein kinase CSK (2395 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RPS6KA5 Tchem Ribosomal protein S6 kinase alpha 5 (3355 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PRKCE Tchem Protein kinase C epsilon (1520 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PRKD3 Tchem Protein kinase C nu (2315 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PRKD1 Tchem Protein kinase C mu (1904 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAF1 Tclin Serine/threonine-protein kinase RAF (4169 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SYK Tclin Tyrosine-protein kinase SYK (7372 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ITK Tclin Tyrosine-protein kinase ITK/TSK (3699 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RPS6KA6 Tchem Ribosomal protein S6 kinase alpha 6 (2027 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

PIK3CA PI3-kinase p110-alpha subunit (51 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prkcd Protein kinase C delta (192 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr4 Fibroblast growth factor receptor 4 (138 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Camk2g CaM kinase II gamma (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Tec Tyrosine-protein kinase TEC (25 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Schistosoma mansoni (6170 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Tgfbr1 TGF-beta receptor type-1 (52 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NRK-52E (51 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
INCHI 1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChi Key FHYUGAJXYORMHI-UHFFFAOYSA-N
Smiles C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Isomeric SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
分子量 384.39

化学和物理性质

溶解性 Soluble in DMSO (77 mg/ml at 25 °C), ethanol (45 mg/ml at 25 °C), DMF (~20 mg/ml), DMSO:PBS (pH 7.2) (1:1) (~ 0.5 mg/ml), and water (<1 mg/ml at 25 °C).
敏感性 对热敏感；对光敏感
熔点 214 °C(dec.)
分子量 384.400 g/mol
XLogP3 2.700
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 384.122 Da
单同位素质量Monoisotopic Mass 384.122 Da
拓扑极表面积Topological Polar Surface Area 103.000 Ų
重原子数Heavy Atom Count 29
形式电荷Formal Charge 0
复杂度Complexity 582.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到10个结果

批号(Lot Number) 证书类型 货号
H2512469 分析证书 S125924
H2512468 分析证书 S125924
H2512470 分析证书 S125924
G2430449 分析证书 S125924
G2430451 分析证书 S125924
G2517066 分析证书 S125924
G2430450 分析证书 S125924
G2430476 分析证书 S125924
K2125415 分析证书 S125924
I1509074 分析证书 S125924

可替换产品

  1. SB431542
    SB431542

    ¥509.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站? 引用文献检索

引用文献

1. Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A et al..  (2002)  Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5)..  J Med Chem,  45  (5): (999-1001).  [PMID:11855979]
2. Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS.  (2002)  SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7..  Mol Pharmacol,  62  (1): (65-74).  [PMID:12065756]
3. Minutti CM et al..  (2019)  A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation..  Immunity,  50  (3): (645-654.e6).  [PMID:30770250]
4. Chen H et al..  (2012)  Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury..  Stem Cells,  30  (9): (1948-60).  [PMID:22696116]
5. Liberti DC et al..  (2021)  Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury..  Cell Rep,  35  (6): (109092).  [PMID:33979629]
6. Salehi H et al..  (2019)  Application of Hanging Drop Culture for Retinal Precursor-Like Cells Differentiation of Human Adipose-Derived Stem Cells Using Small Molecules..  J Mol Neurosci,  [PMID:31363912]
7. André PA et al..  (2015)  BARD1 mediates TGF-ß signaling in pulmonary fibrosis..  Respir Res,  16  (118).  [PMID:26415510]
8. Kutsche LK et al..  (2018)  Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis..  Cell Syst,  7  (4): (438-452.e8).  [PMID:30292704]
9. Abarca-Buis R et al..  (2020)  Control of fibrosis by TGFß signalling modulation promotes redifferentiation during limited regeneration of mouse ear..  Int J Dev Biol,  64  (7-8-9): (423-432).  [PMID:33063836]
10. Keatinge M et al..  (2021)  CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury..  PLoS Genet,  17  (4): (e1009515).  [PMID:33914736]
11. Konishi S et al..  (2022)  Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures..  STAR Protoc,  3  (2): (101447).  [PMID:35712012]
12. Xiang Y et al..  (2020)  Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons..  Mol Cell,  79  (84-98.e9).  [PMID:32526163]
13. Zong W et al..  (2015)  Estradiol plays a role in regulating the expression of lysyl oxidase family genes in mouse urogenital tissues and human Ishikawa cells..  J Zhejiang Univ Sci B,  16  (10): (857-64).  [PMID:26465133]
14.  (1991)  From the Centers for Disease Control. AIDS Clinical Trials Information Service..  JAMA,  266  (13): (1756).  [PMID:1653860]
15. Teisanu RM et al..  (2011)  Functional analysis of two distinct bronchiolar progenitors during lung injury and repair..  Am J Respir Cell Mol Biol,  44  (6): (794-803).  [PMID:20656948]
16. Xiang Y et al..  (2018)  Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids..  Curr Protoc Stem Cell Biol,  47  [PMID:30854156]
17. Xiang Y et al..  (2020)  Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development..  STAR Protoc,  1  [PMID:33103124]
18. Xiang Y et al..  (2019)  hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids..  Cell Stem Cell,  24  (3): (487-497.e7).  [PMID:30799279]
19. Wimmer RA et al..  (2019)  Human blood vessel organoids as a\xa0model of\xa0diabetic vasculopathy..  Nature,  565  (7740): (505-510).  [PMID:30651639]
20. Katsura H et al..  (2020)  Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction..  Cell Stem Cell,  27  (6): (890-904.e8).  [PMID:33128895]
21. Malaguti M et al..  (2019)  Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation..  Dev Cell,  50  (4): (462-477.e5).  [PMID:31204172]
22. Khanam R et al..  (2022)  Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries..  Sci Rep,  12  (9898).  [PMID:35701493]
23. Ashja-Arvan M et al..  (2020)  Impact of IFN-ß and LIF overexpression on human adipose-derived stem cells properties..  J Cell Physiol,  [PMID:32324266]
24. Kim D et al..  (2015)  Impaired osteogenesis in Menkes disease-derived induced pluripotent stem cells..  Stem Cell Res Ther,  6  (160).  [PMID:26347346]
25. Sabate-Soler S et al..  (2022)  Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality..  Glia,  70  (7): (1267-1288).  [PMID:35262217]
26. Xu M et al..  (2021)  MicroRNA-17-5p restrains the dysfunction of Ang-II induced podocytes by suppressing secreted modular calcium-binding protein 2 via NF-κB and TGFβ signaling..  Environ Toxicol,  36  (7): (1402-1411).  [PMID:33835671]
27. Liu H et al..  (2022)  MicroRNA-642b-3p functions as an oncomiR in gastric cancer by down-regulating the CUB and sushi multiple domains protein 1/smad axis..  Bioengineered,  13  (4): (9613-9627).  [PMID:35412956]
28. Zhu K et al..  (2014)  MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells..  Sci Rep,  4  (5524).  [PMID:25027009]
29. Hargus G et al..  (2014)  Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain..  Cell Rep,  8  (6): (1697-703).  [PMID:25220454]
30. Zhang M et al..  (2022)  Prkg2 regulates alveolar type 2-mediated re-alveolarization..  Stem Cell Res Ther,  13  (111).  [PMID:35313961]
31. Ateaque S et al..  (2022)  Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC..  J Neurochem,  161  (6): (463-477).  [PMID:35536742]
32. Esteves TC et al..  (2011)  Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline..  Aging Cell,  10  (80-95).  [PMID:20969722]
33. Yang YH et al..  (2016)  Stromal Tissue Rigidity Promotes Mesenchymal Stem Cell-Mediated Corneal Wound Healing Through the Transforming Growth Factor ß Signaling Pathway..  Stem Cells,  34  (10): (2525-2535).  [PMID:27250866]
34. Kelly TJ et al..  (2019)  Temporal Control of the TGF-ß Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities..  Cell Rep,  29  (9): (2702-2717.e7).  [PMID:31775039]
35. Kang Y et al..  (2016)  Transforming Growth Factor-ß Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors..  Clin Cancer Res,  22  (19): (4934-4946).  [PMID:27126993]
36. Epping MT et al..  (2015)  TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFß signaling activation..  Cell Death Differ,  22  (8): (1353-62).  [PMID:25613376]
37. Jinyue Zhu, Weiqing Wang, Xia Wu.  (2020)  Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF-κB pathway.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,  521  (1055).  [PMID:31733831] [10.1016/j.bbrc.2019.10.178]
38. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou.  (2019)  Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro.  Experimental and Therapeutic Medicine,  17  (1): (251-259).  [PMID:30651790] [10.3892/etm.2018.6909]
39. Huan Chen, Jin Liu, Jia Zhang, Yuqian Chen, Yan Wang, Yuanjie Qiu, Huizhong Hu, Limin Chai, Qianqian Zhang, Qingting Wang, Manxiang Li.  (2025)  USP22/BRD4 mediated hedgehog pathway activation contributes to airway remodeling in asthma.  INTERNATIONAL IMMUNOPHARMACOLOGY,  153  (114538).  [PMID:40132456] [10.1016/j.intimp.2025.114538]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)