| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S107694-20mg |
20mg |
现货  |
| |
| S107694-100mg |
100mg |
现货 |
|
| 别名 | 6,7,8,9,10,11-六氢-1,6,6-三甲基-10,11-二氧代-菲并[1,2-b]呋喃-2-磺酸钠 | 1,6,6-三甲基-10,11-二氧代-6,7,8,9,10,11-六氢菲并[1,2-b]呋喃-2-磺酸钠 |
|---|---|
| 英文别名 | Danshen-201 | Sodium tanshinone II A sulfonate | TanshinoneIIA | SULFOTANSHINONE SODIUM II-A | DTXSID00219953 | TANSHINONE IIA-SULFONIC SODIUM | UNII-IVJ88KQ4XN | DS 201 | sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sul |
| 规格或纯度 | 分析标准品, Moligand™, ≥98% |
| 英文名称 | Sodium Tanshinone IIA |
| 生化机理 | 丹参酮ⅡA磺酸盐是丹参酮ⅡA的水溶性衍生物，在啮齿动物肝炎和脓毒症模型中表现出抗炎特性。丹参酮ⅡA磺酸盐靶向Ca2+激活的钾通道和羧酸酯酶2。最近的研究表明，丹参酮ⅡA磺酸盐而非丹参酮ⅡA可作为人类嘌呤受体P2X7的强效负变构调节剂。 抗炎，强效的人类嘌呤受体P2X7的负变构调节剂。 |
| 储存温度 | 2-8°C储存,避光 |
| 运输条件 | 冰袋运输 |
| 纯度 | ≥98% |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate |
| INCHI | 1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1 |
| InChi Key | AZEZEAABTDXEHR-UHFFFAOYSA-M |
| Smiles | CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+] |
| Isomeric SMILES | CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+] |
| 分子量 | 396.39 |
| 密度 | 1.209 |
|---|---|
| 敏感性 | 对湿度敏感；对光线敏感 |
| 熔点 | 209°C-210°C |
| 分子量 | 396.400 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 396.064 Da |
| 单同位素质量Monoisotopic Mass | 396.064 Da |
| 拓扑极表面积Topological Polar Surface Area | 113.000 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 742.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| WGK Germany | 3 |
|---|---|
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
¥132.72
| 1. Heng Yan-Yan, Shang Hui-Juan, Zhang Xia-ze, Wei Wei. (2023) Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice. BMC Cardiovascular Disorders, 23 (1): (1-12). [PMID:37697234] [10.1186/s12872-023-03485-4] |
| 2. Peng-Xiao Chen, Yi-Lin Zhang, Jia-Wen Xu, Ming-Hao Yu, Jie-Hong Huang, Lei Zhao, Wen-Liang Zhou. (2017) Sodium tanshinone IIA sulfonate stimulated Cl− secretion in mouse trachea. PLoS One, 12 (5): (e0178226). [PMID:28542554] [10.1371/journal.pone.0178226] |
| 3. Wei Wei, Heng Yan-Yan, Wu Fei-Fei, Dong Hao-Yu, Zhang Peng-Fei, Li Jing-Xia, Liu Chun-Yan, Yang Bing-Jie, Fu Jia-Ning, Liang Xin-Yue. (2024) Sodium Tanshinone IIA Sulfonate alleviates vascular senescence in diabetic mice by modulating the A20-NFκB-NLRP3 inflammasome-catalase pathway. Scientific Reports, 14 (1): (1-16). [PMID:39085294] [10.1038/s41598-024-68169-1] |
| 4. Liu Hai-Hua, Wei Wei, Wu Fei-Fei, Cao Lu, Yang Bing-Jie, Fu Jia-Ning, Li Jing-Xia, Liang Xin-Yue, Dong Hao-Yu, Heng Yan-Yan, Zhang Peng-Fei. (2024) Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway. BMC Cardiovascular Disorders, 24 (1): (1-13). [PMID:38992615] [10.1186/s12872-024-03990-0] |
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