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水杨酰苯胺

COA COA
    级别和纯度:
  • ≥98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
S106788-1g
 1g 现货 Stock Image
S106788-5g
 5g 现货 Stock Image
S106788-25g
 25g 现货 Stock Image
S106788-100g
 100g 现货 Stock Image
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Anti-infection (2804) HIV (248) HIV Integrase (29) Metabolic Enzyme/Protease (4889) Nucleic Acid Metabolism (949) Virus (3767) 酰胺 (351) 非杂环砌块 (8221)
main product photo

基本描述

别名 N-苯柳酰胺 | N-苯基水杨酰胺 | N-水杨酰苯胺 | 2-羟基-N-苯基苯酰胺 | 2-羟基苯酰替苯胺
英文别名 Pharmakon1600-00300618 | Anilid kyseliny salicylove [Czech] | Salifebrin | CHEBI:239133 | HY-B1408 | NCGC00076924-03 | SALICYLANILIDE [WHO-DD] | AKOS000119673 | DTXCID501784 | o-Hydroxybenzanilide | S0007 | SALICYLANILIDE [MI] | Shirlan (VAN) | Shirlan Ex
规格或纯度 ≥98%
英文名称 Salicylanilide
储存温度 室温,充氩
运输条件 常规运输
产品介绍

易溶于醇、醚、苯和氯仿，微溶于水。在空气中稳定，遇光颜色变深。

It is employed as a drug used to treat rheumatoid arthritis and has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. It is used mainly in medicated soaps.

Salicylanilide inhibited mycobacterial isocitrate lyase (ICL) and showed a significant antimycobacterial effect.

It is employed as a drug used to treat rheumatoid arthritis and has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. It is used mainly in medicated soaps.
纯度 ≥98%

关联靶点（人）

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AHR Tclin Aryl hydrocarbon receptor (1071 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
P4HB Tchem Protein disulfide-isomerase (716 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTT Tchem Huntingtin (19182 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
microRNA 21 (64692 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CGA Tbio Glycoprotein hormones alpha chain (29278 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSPD1 Tbio HSP60/HSP10 (366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TST Tchem Thiosulfate sulfurtransferase (144 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterobacter cloacae (7976 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterococcus faecium (13803 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium avium (4587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium kansasii (6484 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bos taurus (956 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
clpP ATP-dependent Clp protease proteolytic subunit (245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
stx1 Shiga toxin (517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
groL GroEL/GroES (1042 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504751192
EC号 201-727-8
分子类型 小分子
IIUPAC Name 2-hydroxy-N-phenylbenzamide
INCHI 1S/C13H11NO2/c15-12-9-5-4-8-11(12)13(16)14-10-6-2-1-3-7-10/h1-9,15H,(H,14,16)
InChi Key WKEDVNSFRWHDNR-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2O
Isomeric SMILES C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2O
PubChem CID 6872
分子量 213.23
Beilstein号 1108135
Reaxy-Rn 1108135

化学和物理性质

溶解性 可溶于水
密度 1.278
沸点 294.3ºC at 760 mmHg
熔点 136-138°C
分子量 213.230 g/mol
XLogP3 3.300
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 213.079 Da
单同位素质量Monoisotopic Mass 213.079 Da
拓扑极表面积Topological Polar Surface Area 49.300 Ų
重原子数Heavy Atom Count 16
形式电荷Formal Charge 0
复杂度Complexity 236.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07,   GHS09
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H400: 对水生生物有剧毒
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P273: 避免释放到环境中。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P391: 收集溢出物

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 2
RTECS VN7850000
Merck Index 8330
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

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C of A & Other Certificates(BSE/TSE, COO):
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找到7个结果

批号(Lot Number) 证书类型 货号
K2330277 分析证书 S106788
K2330278 分析证书 S106788
K2330279 分析证书 S106788
K2330280 分析证书 S106788
K2330358 分析证书 S106788
K2330359 分析证书 S106788
K2330360 分析证书 S106788

引用文献

1. E Piscopo,M V Diurno,M T Cereti Mazza,G Cirino,C Romano Carratelli,I Nuzzo.  (1982-10-30)  [New alo-, nitro-, and alonitro- derivatives of o-hydroxybenzanilide and their antimicrobial activity]..  Bollettino della Societa italiana di biologia sperimentale,  58  ((20)): (1309-1314).  [PMID:6760880]
2. S C Mitchell,H M Norbury,R H Waring,P M Gadsden,P B Wood.  (1982-02-01)  A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat..  Xenobiotica; the fate of foreign compounds in biological systems,  12  ((2)): (93-99).  [PMID:7090426]
3. L NOSKO.  (1958-05-01)  [External therapy of chronic dermatoses]..  Klinische Medizin; osterreichische Zeitschrift fur wissenschaftliche und praktische Medizin,  13  ((5)): (205-209).  [PMID:13550751]
4. R O BURNS,J M DANIEL,H JACKSON,W O WEST.  (1958-06-01)  Salicylate intoxication treated with artificial kidney..  The West Virginia medical journal,  54  ((6)): (198-199).  [PMID:13558085]
5. W OTTO.  (1958-12-19)  [Prevention and therapy of fungus diseases of the foot]..  Medizinische Klinik,  53  ((51)): (2197-2198).  [PMID:13622158]
6. Michael E Brown,Jeffrey N Fitzner,Tracey Stevens,Wilson Chin,Clifford D Wright,Jim P Boyce.  (2008-08-22)  Salicylanilides: selective inhibitors of interleukin-12p40 production..  Bioorganic & medicinal chemistry,  16  ((18)): (8760-8764).  [PMID:18715785]
7. Jim P Boyce,Michael E Brown,Wilson Chin,Jeffrey N Fitzner,Raymond J Paxton,Min Shen,Tracey Stevens,Martin F Wolfson,Clifford D Wright.  (2008-09-04)  Identification of 14-3-3zeta by chemical affinity with salicylanilide inhibitors of interleukin-12p40 production..  Bioconjugate chemistry,  19  ((9)): (1775-1784).  [PMID:18763820]
8. Juana M Férriz,Katerina Vávrová,Filip Kunc,Ales Imramovský,Jirina Stolaríková,Eva Vavríková,Jarmila Vinsová.  (2010-01-12)  Salicylanilide carbamates: antitubercular agents active against multidrug-resistant Mycobacterium tuberculosis strains..  Bioorganic & medicinal chemistry,  18  ((3)): (1054-1061).  [PMID:20060303]
9. Ales Imramovsky,Matus Pesko,Juana Monreal Ferriz,Katarina Kralova,Jarmila Vinsova,Josef Jampilek.  (2011-07-05)  Photosynthesis-Inhibiting efficiency of 4-chloro-2-(chlorophenylcarbamoyl)phenyl alkylcarbamates..  Bioorganic & medicinal chemistry letters,  21  ((15)): (4564-4567).  [PMID:21724391]
10. Monika Vidová,Janette Bobáľová,Peter Smigáň.  (2011-10-01)  Harmaline-resistant mutant of Methanothermobacter thermautotrophicus with a lesion in Na(+)/H(+) antiport..  General physiology and biophysics,  30 Spec No  (S54-S60).  [PMID:21869452]
11. A Atef El-Sayed,Sohad M Dorgham,A Kantouch.  (2011-11-26)  Application of reactive salicylanilide to viscose fabrics as antibacterial and antifungus finishing..  International journal of biological macromolecules,  50  ((1)): (273-276).  [PMID:22115716]
12. Martin Krátký,Jarmila Vinšová,Vladimír Buchta.  (2012-05-03)  In vitro antibacterial and antifungal activity of salicylanilide pyrazine-2-carboxylates..  Medicinal chemistry (Shariqah (United Arab Emirates)),  8  ((4)): (732-741).  [PMID:22548336]
13. Martin Krátký,Jarmila Vinšová,Vladimír Buchta.  (2012-06-06)  In vitro antibacterial and antifungal activity of salicylanilide benzoates..  TheScientificWorldJournal,  2012  (290628-290628).  [PMID:22666101]
14. Rohit Sharma,Oisik Das,Satyawan G Damle,Anil K Sharma.  (2013-03-20)  Isocitrate lyase: a potential target for anti-tubercular drugs..  Recent patents on inflammation & allergy drug discovery,  7  ((2)): (114-123).  [PMID:23506018]
15. Martin Enmark,Dennis Åsberg,Andrew Shalliker,Jörgen Samuelsson,Torgny Fornstedt.  (2015-05-24)  A closer study of peak distortions in supercritical fluid chromatography as generated by the injection..  Journal of chromatography. A,  1400  (131-139).  [PMID:26002105]
16. Peter R Bradshaw,Ian D Wilson,Rachel Upcott Gill,Philip J Butler,Clive Dilworth,Toby J Athersuch.  (2018-02-07)  Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems..  Scientific reports,  8  ((1)): (2405-2405).  [PMID:29402925]
17. Yuya Ohtsuki,Seigo Sanoh,Masataka Santoh,Yoko Ejiri,Shigeru Ohta,Yaichiro Kotake.  (2018-12-28)  Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives..  Biochemical and biophysical research communications,  509  ((1)): (287-293).  [PMID:30587336]
18. Ronald Domalaon,Oreofe Okunnu,George G Zhanel,Frank Schweizer.  (2019-04-28)  Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli..  The Journal of antibiotics,  72  ((8)): (605-616).  [PMID:31028351]
19. Damien Mooney,Catherine Coxon,Karl G Richards,Laurence Gill,Per-Erik Mellander,Martin Danaher.  (2019-05-28)  Development and Optimisation of a Multiresidue Method for the Determination of 40 Anthelmintic Compounds in Environmental Water Samples by Solid Phase Extraction (SPE) with LC-MS/MS Detection..  Molecules (Basel, Switzerland),  24  ((10)): [PMID:31121991]
20. S A Rummel,A J Kraker,R W Steinkampf,K E Hook,W D Klohs.  (1995-09-04)  Role of a small molecular weight phosphoprotein in the mechanism of action of CI-994 (N-acetyldinaline)..  International journal of cancer,  62  ((5)): (636-642).  [PMID:7665238]
21. K A ROSS,J H MAYER,M M SHEPHERD.  (1958-05-03)  Osteoarthritis of the knee; treatment by local injection of salicylate compounds..  British medical journal,  1  ((5078)): (1040-1043).  [PMID:13536413]
22. S A KAPLAN,F T DEL CARMEN.  (1958-05-01)  Experimental salicylate poisoning: observations on the effects of carbonic anhydrase inhibitor and bicarbonate..  Pediatrics,  21  ((5)): (762-770).  [PMID:13542121]
23. E E FISCHEL,C W FRANK,A J BOLTAX,M ARCASOY.  (1958-08-01)  Observations on the treatment of rheumatic fever with salicylate, ACTH and cortisone. II. Combined salicylate and corticoid therapy and attempts at rebound suppression..  Arthritis and rheumatism,  1  ((4)): (351-366).  [PMID:13560346]
24. O PRIESSNITZ.  (1958-05-02)  [Extranit therapy of peripheral circulatory disorders]..  Munchener medizinische Wochenschrift (1950),  100  ((18)): (729-730).  [PMID:13565943]
25. A STIRN.  (1959-02-21)  [Treatment of sweaty feet]..  Die Medizinische,  4  ((8)): (348-348).  [PMID:13643465]
26. B De Spiegeleer,B Baert,N Diericx,D Seghers,F Verpoort,L Van Vooren,C Burvenich,G Slegers.  (2007-03-14)  Assessment of the solid-state composition of an active salicylanilide compound by FT-Raman spectroscopy..  Journal of pharmaceutical and biomedical analysis,  44  ((1)): (254-257).  [PMID:17349766]
27. Jarmila Vinsova,Ales Imramovsky,Vladimir Buchta,Martina Ceckova,Martin Dolezal,Frantisek Staud,Josef Jampilek,Jarmila Kaustova.  (2007-08-19)  Salicylanilide acetates: synthesis and antibacterial evaluation..  Molecules (Basel, Switzerland),  12  ((1)): (1-12).  [PMID:17693949]
28. Ales Imramovský,Jarmila Vinsová,Juana Monreal Férriz,Vladimír Buchta,Josef Jampílek.  (2008-12-17)  Salicylanilide esters of N-protected amino acids as novel antimicrobial agents..  Bioorganic & medicinal chemistry letters,  19  ((2)): (348-351).  [PMID:19081718]
29.  (2012-01-25)  Surveillance. SAC C vs disease surveillance report. Cases of poisoning in Scottish cattle and sheep..  The Veterinary record,  169  ((24)): (628-631).  [PMID:22272399]
30. Martin Krátký,Jarmila Vinšová,Eva Novotná,Jana Mandíková,Vladimír Wsól,František Trejtnar,Vít Ulmann,Jiřina Stolaříková,Steve Fernandes,Shridhar Bhat,Jun O Liu.  (2012-07-07)  Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase..  Tuberculosis (Edinburgh, Scotland),  92  ((5)): (434-439).  [PMID:22765970]

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