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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S106638-25g |
25g |
现货 ![]() |
| |
| S106638-100g |
100g |
现货 ![]() |
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| S106638-250g |
250g |
现货 ![]() |
| |
| S106638-500g |
500g |
现货 ![]() |
|
| 别名 | 对磺酰胺苯甲酸 | 4-羧基苯磺酰胺 | 4-磺酰氨基苯甲酸 | 卡西尼特 |
|---|---|
| 英文别名 | Tox21_110021 | Carzenidum [INN-Latin] | Maybridge1_002385 | Z53021532 | aromatic/heteroaromatic sulfonamide 23 | JMC52646 Compound 23 | MFCD00007938 | NCI60_001869 | p-Sulfonamidobenzoic acid | Carzenide (INN) | NCGC00021607-04 | 4-Sulfamidobenzoic acid | |
| 规格或纯度 | ≥95% |
| 英文名称 | 4-Sulfamylbenzoic acid |
| 运输条件 | 常规运输 |
| 产品介绍 |
Product Application: Sulfamoylbenzoic acid is a moiety of sulfamyl diuretics or antihypertensive. It is used as an antiviral and an intermediate for the manufacture of frusemide which used as a diuretic and as an antihypertensive. |
| 纯度 | ≥95% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 488180873 |
|---|---|
| EC号 | 205-327-4 |
| 分子类型 | 小分子 |
| IIUPAC Name | 4-sulfamoylbenzoic acid |
| INCHI | 1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12) |
| InChi Key | UCAGLBKTLXCODC-UHFFFAOYSA-N |
| Smiles | C1=CC(=CC=C1C(=O)O)S(=O)(=O)N |
| Isomeric SMILES | C1=CC(=CC=C1C(=O)O)S(=O)(=O)N |
| PubChem CID | 8739 |
| 分子量 | 201.2 |
| Beilstein号 | 1875393 |
| Reaxy-Rn | 1875393 |
| 溶解性 | Insoluble in water. |
|---|---|
| 密度 | 1.536 |
| 熔点 | 285-295°C |
| 分子量 | 201.200 g/mol |
| XLogP3 | 0.500 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 201.01 Da |
| 单同位素质量Monoisotopic Mass | 201.01 Da |
| 拓扑极表面积Topological Polar Surface Area | 106.000 Ų |
| 重原子数Heavy Atom Count | 13 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 284.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H312: 皮肤接触有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H332: 吸入有害 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P330: 漱口 P302+P352: 如皮肤沾染:用水充分清洗。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽:请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | DH6820000 |
| Merck Index | 1876 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 | |
| 分析证书 | S106638 |
¥164.72
| 1. Vullo D, Innocenti A, Nishimori I, Pastorek J, Scozzafava A, Pastoreková S, Supuran CT. (2005) Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?. Bioorg Med Chem Lett, 15 (4): (963-9). [PMID:15686894] |
| 2. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT. (2005) Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.. Bioorg Med Chem Lett, 15 (17): (3828-33). [PMID:16039848] |
| 3. F Poncelet,M Mercier,J Lederer. (1980-08-01) Saccharin: para forms of some impurities are not mutagenic in Salmonella typhimurium.. Food and cosmetics toxicology, 18 ((4)): (453-453). [PMID:7007186] |
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| 6. Daniela Vullo,Juha Voipio,Alessio Innocenti,Claudio Rivera,Harri Ranki,Andrea Scozzafava,Kai Kaila,Claudiu T Supuran. (2005-02-03) Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.. Bioorganic & medicinal chemistry letters, 15 ((4)): (971-976). [PMID:15686895] |
| 7. Jean-Yves Winum,Jean-Michel Dogné,Angela Casini,Xavier de Leval,Jean-Louis Montero,Andrea Scozzafava,Daniela Vullo,Alessio Innocenti,Claudiu T Supuran. (2005-03-18) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.. Journal of medicinal chemistry, 48 ((6)): (2121-2125). [PMID:15771455] |
| 8. Isao Nishimori,Daniela Vullo,Alessio Innocenti,Andrea Scozzafava,Antonio Mastrolorenzo,Claudiu T Supuran. (2005-11-24) Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.. Journal of medicinal chemistry, 48 ((24)): (7860-7866). [PMID:16302824] |
| 9. Isao Nishimori,Daniela Vullo,Tomoko Minakuchi,Kaori Morimoto,Saburo Onishi,Andrea Scozzafava,Claudiu T Supuran. (2006-02-07) Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.. Bioorganic & medicinal chemistry letters, 16 ((8)): (2182-2188). [PMID:16459077] |
| 10. Isao Nishimori,Tomoko Minakuchi,Kaori Morimoto,Shuichi Sano,Saburo Onishi,Hiroaki Takeuchi,Daniela Vullo,Andrea Scozzafava,Claudiu T Supuran. (2006-03-17) Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.. Journal of medicinal chemistry, 49 ((6)): (2117-2126). [PMID:16539401] |
| 11. Isao Nishimori,Tomoko Minakuchi,Saburo Onishi,Daniela Vullo,Andrea Scozzafava,Claudiu T Supuran. (2007-01-19) Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.. Journal of medicinal chemistry, 50 ((2)): (381-388). [PMID:17228881] |
| 12. Brendan L Wilkinson,Laurent F Bornaghi,Anthony D Wright,Todd A Houston,Sally-Ann Poulsen. (2007-01-30) Anti-mycobacterial activity of a bis-sulfonamide.. Bioorganic & medicinal chemistry letters, 17 ((5)): (1355-1357). [PMID:17258454] |
| 13. Isao Nishimori,Tomoko Minakuchi,Takuhiro Kohsaki,Saburo Onishi,Hiroaki Takeuchi,Daniela Vullo,Andrea Scozzafava,Claudiu T Supuran. (2007-05-08) Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.. Bioorganic & medicinal chemistry letters, 17 ((13)): (3585-3594). [PMID:17482815] |
| 14. Semra Isik,Feray Kockar,Meltem Aydin,Oktay Arslan,Ozen Ozensoy Guler,Alessio Innocenti,Andrea Scozzafava,Claudiu T Supuran. (2009-01-07) Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.. Bioorganic & medicinal chemistry, 17 ((3)): (1158-1163). [PMID:19124253] |
| 15. Mika Hilvo,Anna Maria Salzano,Alessio Innocenti,Markku S Kulomaa,Andrea Scozzafava,Andrea Scaloni,Seppo Parkkila,Claudiu T Supuran. (2009-02-06) Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.. Journal of medicinal chemistry, 52 ((3)): (646-654). [PMID:19193158] |
| 16. Oral Oltulu,Mehmet M Yaşar,Erol Eroğlu. (2009-03-24) A QSAR study on relationship between structure of sulfonamides and their carbonic anhydrase inhibitory activity using the eigenvalue (EVA) method.. European journal of medicinal chemistry, 44 ((9)): (3439-3444). [PMID:19303173] |
| 17. Tomoko Minakuchi,Isao Nishimori,Daniela Vullo,Andrea Scozzafava,Claudiu T Supuran. (2009-03-26) Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.. Journal of medicinal chemistry, 52 ((8)): (2226-2232). [PMID:19317447] |
| 18. Isao Nishimori,Tomoko Minakuchi,Daniela Vullo,Andrea Scozzafava,Alessio Innocenti,Claudiu T Supuran. (2009-04-03) Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.. Journal of medicinal chemistry, 52 ((9)): (3116-3120). [PMID:19338333] |
| 19. Alessio Innocenti,Rebecca A Hall,Christine Schlicker,Andrea Scozzafava,Clemens Steegborn,Fritz A Mühlschlegel,Claudiu T Supuran. (2009-05-20) Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.. Bioorganic & medicinal chemistry, 17 ((13)): (4503-4509). [PMID:19450983] |
| 20. Anthony Bertucci,Alessio Innocenti,Didier Zoccola,Andrea Scozzafava,Sylvie Tambutté,Claudiu T Supuran. (2009-06-13) Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.. Bioorganic & medicinal chemistry, 17 ((14)): (5054-5058). [PMID:19520577] |
| 21. Fabrizio Carta,Alfonso Maresca,Adrian Suarez Covarrubias,Sherry L Mowbray,T Alwyn Jones,Claudiu T Supuran. (2009-10-23) Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.. Bioorganic & medicinal chemistry letters, 19 ((23)): (6649-6654). [PMID:19846301] |
| 22. Pascale Joseph,François Turtaut,Safia Ouahrani-Bettache,Jean-Louis Montero,Isao Nishimori,Tomoko Minakuchi,Daniela Vullo,Andrea Scozzafava,Stephan Köhler,Jean-Yves Winum,Claudiu T Supuran. (2010-02-18) Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.. Journal of medicinal chemistry, 53 ((5)): (2277-2285). [PMID:20158185] |
| 23. Anthony Bertucci,Alessio Innocenti,Andrea Scozzafava,Sylvie Tambutté,Didier Zoccola,Claudiu T Supuran. (2011-01-07) Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.. Bioorganic & medicinal chemistry letters, 21 ((2)): (710-714). [PMID:21208801] |
| 24. Pascale Joseph,Safia Ouahrani-Bettache,Jean-Louis Montero,Isao Nishimori,Tomoko Minakuchi,Daniela Vullo,Andrea Scozzafava,Jean-Yves Winum,Stephan Köhler,Claudiu T Supuran. (2011-01-22) A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.. Bioorganic & medicinal chemistry, 19 ((3)): (1172-1178). [PMID:21251841] |
| 25. Isao Nishimori,Tomoko Minakuchi,Daniela Vullo,Andrea Scozzafava,Claudiu T Supuran. (2011-07-16) Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.. Bioorganic & medicinal chemistry, 19 ((16)): (5023-5030). [PMID:21757360] |
| 26. (2011-09-16) New bitter blocker discovered, study finds.. Journal of the American Dental Association (1939), 142 ((8)): (901-901). [PMID:21919220] |
| 27. Anna Ohradanova,Daniela Vullo,Silvia Pastorekova,Jaromir Pastorek,Daniel J Jackson,Gert Wörheide,Claudiu T Supuran. (2012-01-31) Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.. Bioorganic & medicinal chemistry, 20 ((4)): (1403-1410). [PMID:22285172] |
| 28. Massinissa Si Mehand,Bala Srinivasan,Gregory De Crescenzo. (2015-10-31) Optimizing Multiple Analyte Injections in Surface Plasmon Resonance Biosensors with Analytes having Different Refractive Index Increments.. Scientific reports, 5 (15855-15855). [PMID:26515024] |
| 29. Tiphaine Rogez-Florent,Catherine Foulon,Anne-Sophie Drucbert,Nadège Schifano,Perrine Six,Stéphanie Devassine,Patrick Depreux,Pierre-Marie Danzé,Laurence Goossens,Cécile Danel,Jean-François Goossens. (2017-01-23) Chiral separation of new sulfonamide derivatives and evaluation of their enantioselective affinity for human carbonic anhydrase II by microscale thermophoresis and surface plasmon resonance.. Journal of pharmaceutical and biomedical analysis, 137 (113-122). [PMID:28110167] |
| 30. Daniel J Orton,Malak M Tfaily,Ronald J Moore,Brian L LaMarche,Xueyun Zheng,Thomas L Fillmore,Rosalie K Chu,Karl K Weitz,Matthew E Monroe,Ryan T Kelly,Richard D Smith,Erin S Baker. (2017-11-22) A Customizable Flow Injection System for Automated, High Throughput, and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements.. Analytical chemistry, 90 ((1)): (737-744). [PMID:29161511] |
| 31. Sally-Ann Poulsen,Laurent F Bornaghi,Peter C Healy. (2005-10-11) Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II.. Bioorganic & medicinal chemistry letters, 15 ((24)): (5429-5433). [PMID:16213706] |
| 32. Isao Nishimori,Tomoko Minakuchi,Saburo Onishi,Daniela Vullo,Alessandro Cecchi,Andrea Scozzafava,Claudiu T Supuran. (2007-09-11) Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.. Bioorganic & medicinal chemistry, 15 ((23)): (7229-7236). [PMID:17826101] |
| 33. Shinya Tsukiji,Masayoshi Miyagawa,Yousuke Takaoka,Tomonori Tamura,Itaru Hamachi. (2009-03-31) Ligand-directed tosyl chemistry for protein labeling in vivo.. Nature chemical biology, 5 ((5)): (341-343). [PMID:19330012] |