Recombinant Human GPR37 Protein

COA

级别和纯度:

≥95%(SDS-PAGE)
见COA

表达系统: HEK293
Accession #: O15354
蛋白标签: C-10His
生物活性: Immobilized Recombinant Human GPR37 Protein (rp192118) at 1.0 μg/mL can bind Recombinant GPCR/GPR37 Antibody (Ab106130) with the EC50 of 2.9 ng/mL.
内毒素水平: <1.0 EU/μg

有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
rp192118-10μg	10μg	现货
rp192118-50μg	50μg	现货
rp192118-100μg	100μg	现货
rp192118-1mg	1mg	期货

查看相关系列

Accession#:O15354 (2) Gene ID:2861 (2) GPR37 (2)

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基本描述

产品名称	Recombinant Human GPR37 Protein
别名	重组人GPR37蛋白 \| 重组人前酵素受体GPR37蛋白
英文别名	EDNRBL \| Endothelin B receptor-like protein 1 \| ETBR-LP-1 \| G protein-coupled receptor 37 (endothelin receptor type B-like) \| GPR37 \| hET(B)R-LP \| PAELR \| PAELRETBR-LP-1 \| Parkin-associated endothelin receptor-like receptor \| probable G-protein coupled re
规格或纯度	无动物源, 无载体, 生物活性, ActiBioPure™, ≥95%(SDS-PAGE), 见COA
生化机理	GPR37 (G-protein coupled receptor 37), also called ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor), is a 587 aa, 7-transmembrane receptor for the neuroprotective and glioprotective factor prosaposin. It is mainly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus. It is a substrate of the E3 ubiquitin ligase, parkin, which is up-regulated during endoplasmic reticulum stress. In a juvenile form of Parkinson's disease, GPR37 accumulates, contributing to stress-induced neuronal cell death. The extracellular domains (aa 27-265) of human and mouse GPR37 share 68% aa identity. Post-translational: The N-terminus is cleaved by ADAM10 metalloproteinase; mediating limited proteolysis leading to the release of receptor ectodomain by shedding (PubMed:26869225, PubMed:34042202).In addition, cleaved by FURIN between Arg-54 and Asp-55 (PubMed:34042202). Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.
生物活性	Immobilized Recombinant Human GPR37 Protein (rp192118) at 1.0 μg/mL can bind Recombinant GPCR/GPR37 Antibody (Ab106130) with the EC50 of 2.9 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	1-265 aa
序列	MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMHHHHHHHHHH
蛋白标签	C-10His
无载体	Yes
无动物源	Yes
Accession #	O15354
来源	重组表达
预测分子量	29.3 kDa
SDS-PAGE	31.3-53.3 kDa, under reducing conditions; 31.3-53.3 kDa, under non-reducing conditions.

关联靶点（人）

GPR37 Tbio Prosaposin 受体 GPR37(Prosaposin receptor GPR37) (0 活性数据)

点击查看靶蛋白信息： GPR37

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4
浓度	见COA
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	短期储存2-8℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。
分子类型	蛋白质

图片

ELISA: Recombinant Human GPR37 Protein (rp192118)

Recombinant Human GPR37 Protein (rp192118) - ELISA
Immobilized Recombinant Human GPR37 Protein (rp192118) at 1.0 μg/mL can bind Recombinant GPCR/GPR37 Antibody (Ab106130) with the EC50 of 2.9 ng/mL.

SDS-PAGE: Recombinant Human GPR37 Protein (rp192118)

Recombinant Human GPR37 Protein (rp192118) - SDS-PAGE
3 μg/lane of Recombinant Human GPR37 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 31.3-53.3 kDa.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ25F0521569	分析证书	rp192118
ZJ25F0521568	分析证书	rp192118
ZJ25F0521567	分析证书	rp192118

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