Recombinant Human CDK4 Protein

COA

级别和纯度:

无载体

≥90%(SDS-PAGE)

表达系统: E. coli
Accession #: P11802
蛋白标签: N-His
内毒素水平: <1.0 EU/μg

有货

库存信息

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货号 (SKU)	包装规格	是否现货
rp184121-10μg	10μg	现货
rp184121-100μg	100μg	现货
rp184121-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: CDK4

Accession#:P11802 (2) CDK4 (2) Cyclin-dependent kinase 4 (1) Gene ID:1019 (2)

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基本描述

产品名称	Recombinant Human CDK4 Protein
别名	重组人CDK4蛋白 \| 重组人类 CDK4 蛋白
英文别名	cdk4 \| CDK4 protein \| CDK4_HUMAN \| Cell division kinase 4 \| Cell division protein kinase 4 \| CMM 3 \| CMM3 \| Crk3 \| Cyclin dependent kinase 4 \| Cyclin-dependent kinase 4 \| Melanoma cutaneous malignant 3 \| MGC14458 \| p34 cdk4 \| Cdk 4 \| PSK J3 \| PSK-J3
规格或纯度	Carrier Free, ≥90%(SDS-PAGE)
产品介绍	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	2-303 aa
序列	MHHHHHHATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
蛋白标签	N-His
无载体	Yes
无动物源	No
Accession #	P11802
来源	重组表达
预测分子量	34.5 kDa
SDS-PAGE	32.0 kDa, under reducing conditions; 32.0 kDa, under non-reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 20mM Tris, 500mM NaCl, 8M Urea, 120mM imidazole, pH8.0
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human CDK4 Protein (rp184121)

Recombinant Human CDK4 Protein (rp184121) - SDS-PAGE
2 μg/lane of Recombinant Human CDK4 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 32.0 kDa.

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找到2个结果

批号(Lot Number)	证书类型	货号
ZJ24F0707743	分析证书	rp184121
ZJ24F0707742	分析证书	rp184121

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