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Recombinant Human Lamin A Protein

    级别和纯度:
  • 无载体
  • ≥90%(SDS-PAGE)
  • 表达系统: E. coli
  • Accession #: P02545
  • 蛋白标签: N-His
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp183757-10μg
10μg 现货 Stock Image
rp183757-100μg
100μg 现货 Stock Image
rp183757-1mg
1mg 现货 Stock Image

基本描述

产品名称 Recombinant Human Lamin A Protein
别名 重组人Lamin A蛋白 | 重组人类层蛋白A
英文别名 LMNA | LMN1 | FPL | IDC | LFP | CDDC | EMD2 | FPLD | HGPS | LDP1 | LMNC | PRO1 | CDCD1 | Prelamin-A/C | CMD1A | FPLD2 | LMNL1 | CMT2B1 | LGMD1B
规格或纯度 Carrier Free, ≥90%(SDS-PAGE)
产品介绍


Protein Function::
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. 

表达系统 E. coli
种属 人(Human)
氨基酸 2-664 aa
序列 MHHHHHHETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM
蛋白标签 N-His
无载体 Yes
无动物源 No
Accession # P02545
来源 重组表达
预测分子量 74.9 kDa
SDS-PAGE 68.3 kDa, under reducing conditions; 68.3 kDa, under non-reducing conditions

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from 20mM Tris, 500mM NaCl, 8M Urea, pH 8.0
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型 蛋白质

图片

Recombinant Human Lamin A Protein (rp183757) - SDS-PAGE
3 μg/lane of Recombinant Human Lamin A Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 68.3 kDa.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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批号(Lot Number) 证书类型 货号
ZJ24F0708462 分析证书 rp183757
ZJ24F0708458 分析证书 rp183757
ZJ24F0708460 分析证书 rp183757
ZJ24F0708461 分析证书 rp183757

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