Recombinant Human CD72 Protein

COA

级别和纯度:

无动物源

无载体

≥90%(SDS-PAGE)

表达系统: HEK293
Accession #: P21854
蛋白标签: C-His
生物活性: Testing in progress
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp181592-10μg	10μg	现货
rp181592-50μg	50μg	现货
rp181592-100μg	100μg	现货
rp181592-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: CD72

Accession#:P21854 (2) CD72 (2) Gene ID:971 (2)

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基本描述

产品名称	Recombinant Human CD72 Protein
别名	重组人CD72蛋白 \| 重组人 CD72 蛋白
英文别名	CD72 antigen \| B-cell differentiation antigen CD72 \| B cell differentiation antigen CD72 \| CD72 molecule \| CD72_HUMAN \| CD72 \| CD72b \| Ly-19.2 \| Ly-32.2 \| Lyb-2 \| LYB2 \| lyb-2 \| Lyb2
规格或纯度	Animal Free, Carrier Free, ≥90%(SDS-PAGE)
产品介绍	CD72, also known as Lyb‑2, is a 40‑45 kDa type II transmembrane glycoprotein that plays a role in immune system regulation. Mature human CD72 consists of a 95 amino acid (aa) cytoplasmic domain with two immunoreceptor tyrosine‑based inhibitory motifs (ITIMs), a 21 aa transmembrane segment, and a 243 aa extracellular domain with a coiled‑coil domain and a C‑type lectin domain. Within the ECD, human CD72 shares 48% and 44% aa sequence identity with mouse and rat CD72, respectively. CD72 is expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells. CD72 binds to CD5 with mouse/human cross‑reactivity and to Semaphorin 4D/CD100. It associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP‑1. CD72 ligation with antibodies or with Semaphorin 4D induces tyrosine dephosphorylation of the CD72 cytoplasmic domain and its dissociation from SHP‑1, leading to B cell proliferation. Both CD72 and Semaphorin 4D are required for the maintenance of B cell anergy and the regulation of peripheral B cell tolerance as shown by the development of autoimmunity in mice that lack either molecule. In addition to its negative regulation of BCR signaling, CD72 can induce positive signaling in B cells independent of the BCR. CD72 binding to Semaphorin 4D induces cytokine production by monocytes and dendritic cells, inhibits SCF R/c‑kit induced mast cell proliferation and activation, and inhibits the cytolytic activity of NK cells. Semaphorin 4D is expressed on activated NK cells and contributes to the adhesive interaction between NK and CD72+ target cells leading to a more efficient killing and enhanced IFN-gamma secretion.
生物活性	Testing in progress
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	117-359 aa
序列	RYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPDHHHHHH
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P21854
来源	重组表达
预测分子量	28.9 kDa
SDS-PAGE	30.6-37.0 kDa, under reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human CD72 Protein (rp181592)

Recombinant Human CD72 Protein (rp181592) - SDS-PAGE
3 μg/lane of Recombinant Human CD72 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 30.6-37.0 kDa.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0707711	分析证书	rp181592
ZJ24F0707709	分析证书	rp181592
ZJ24F0707710	分析证书	rp181592

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Recombinant Human CD72 Protein

库存信息

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库存信息

基本描述

储存与运输

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

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