Recombinant Human Galectin-1 Protein

COA

级别和纯度:

≥95%(SDS-PAGE)
见COA

表达系统: E. coli
Accession #: P09382
蛋白标签: No tag
生物活性: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/mL.
内毒素水平: <1.0 EU/μg

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货号 (SKU)	包装规格	是否现货
rp179838-10μg	10μg	现货
rp179838-50μg	50μg	现货
rp179838-100μg	100μg	现货
rp179838-1mg	1mg	现货

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点击查看蛋白信息: LGALS1

Accession#:P09382 (3) Galectin-1 (1) Gene ID:3956 (3) LGALS1 (3)

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基本描述

产品名称	Recombinant Human Galectin-1 Protein
别名	重组人Galectin-1蛋白 \| 重组人半乳糖凝集素-1蛋白
英文别名	14 kDa laminin-binding protein \| 14 kDa lectin \| Beta-galactoside-binding lectin L-14-I \| BHL \| DKFZp686E23103 \| GAL1 \| gal-1 \| Galaptin \| galectin 1 \| Galectin1 \| Galectin-1 \| GBP \| HBL \| HLBP14 \| HPL \| L-14 \| Lactose-binding lectin 1 \| Lectin galactosid
规格或纯度	无载体, 生物活性, ActiBioPure™, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Galectin-1, gene name LGALS1 (lectin, galactoside-binding, soluble 1), is a 135 amino acid (aa), 14 kDa, pleiotropic, non-glycosylated, monomeric or homodimeric carbohydrate-binding protein of the prototype galectin family. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments, or secreted via non-classical pathways. Secreted Galectin-1 has immunosuppressive and anti-inflammatory properties and suppresses acute and chronic inflammation and autoimmunity. It contributes to negative selection of developing T cells, immunosuppression by regulatory T cells, resolution of the inflammatory response, and inhibition of immune cell migration, inflammatory cytokine production, and mast cell degranulation. Galectin-1 preferentially binds laminin, fibronectin, 90K/Mac-2BP, CD45, CD43, CD7, CD2, CD3, integrins alpha 4 beta 1, alpha 5 beta 1 and alpha 4 beta 7, and ganglioside GM1. It is produced in a variety of tissues by cells that include endothelial cells, connective tissue fibroblasts, thymic stromal cells, tumor cells, muscle cells, platelets, regulatory T cells, and activated tissue macrophages, B cells, T cells, and dendritic cells. Most of this expression is cytosolic. Human Galectin-1 shares 88% aa sequence identity with mouse, equine and ovine, 90% with rat, and 87% with bovine and porcine Galectin-1. Endothelial cell surface expression, including tumor endothelial cells, is greatly increased by cell activation. Galectin-1 is highly expressed at the maternal-fetal interface and contributes to fetal immune privilege. Its immunosuppressive properties appear to also allow tumor cells to evade immune detection. It selectively controls T cell survival by inducing apoptosis of activated Th1 and Th17 cells, which express Galectin-1-binding glycans, while promoting Th2 cell survival where glycans are sialylated and less recognized. It also induces apoptosis of immature thymocytes. Galectin-1 secreted from bone marrow stromal cells aids B lymphocyte development by contributing to pre-B cell integrin adhesion and receptor signaling. The dimer form of Galectin-1 also induces neutrophil down‑regulation by inducing cell surface exposure of phosphatidylserine that marks the cell for phagocytosis. Galectin-1 can also modulate cell-cell and cell-matrix interactions, and can promote either cell attachment or detachment depending on the cell type and developmental stage.
生物活性	Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	2-135 aa
序列	ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
蛋白标签	No tag
无载体	Yes
无动物源	No
Accession #	P09382
来源	重组表达
预测分子量	14.6 kDa
SDS-PAGE	12.2 kDa, under reducing conditions

储存与运输

物理形态	液体
储存缓冲液	PBS, 10% Glycerol, pH 7.4.
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -20°C for 1 year. Avoid freeze/thaw cycle.
分子类型	蛋白质

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批号(Lot Number)	证书类型	货号
ZJ24F1215846	分析证书	rp179838
ZJ24F1215847	分析证书	rp179838
ZJ24F1215848	分析证书	rp179838
ZJ24F1215849	分析证书	rp179838

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Recombinant Human Galectin-1 Protein

库存信息

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库存信息

基本描述

储存与运输

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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溶液计算器

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