货号 (SKU)

包装规格

是否现货

价格

数量

rp146257-10μg

10μg

现货

rp146257-50μg

50μg

现货

rp146257-100μg

100μg

现货

rp146257-1mg

1mg

期货

基本描述

产品名称	Recombinant Human Galectin-1 Protein
别名	重组人半乳糖凝集素-1蛋白 \| 重组人半乳糖凝集素-1蛋白
英文别名	14 kDa laminin-binding protein \| 14 kDa lectin \| Beta-galactoside-binding lectin L-14-I \| BHL \| DKFZp686E23103 \| GAL1 \| gal-1 \| Galaptin \| galectin 1 \| Galectin1 \| Galectin-1 \| GBP \| HBL \| HLBP14 \| HPL \| L-14 \| Lactose-binding lectin 1 \| Lectin galactosid
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥95%(SDS-PAGE&HPLC)
产品介绍	Purity >95% (SDS-PAGE&HPLC) Endotoxin level <0.1 EU/μg Function May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.Gal-1 is also engaged in many protein-protein interactions. Gal-1 plays a number of crucial roles in neuronal cell differentiation and survival in both the central and the peripheral nervous systems, and the establishment and maintenance of T-cell tolerance and homeostasis in vivo.
生物活性	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10 ng/ml.
内毒素水平	<0.1 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	2-135 aa
序列	ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
纯度	>95% (SDS-PAGE&HPLC)
蛋白标签	No tag
无载体	Yes
无动物源	Yes
Accession #	P09382
来源	重组表达
预测分子量	14.6 kDa
SDS-PAGE	14.6 kDa

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from a 0.2 µm filtered solution in PBS, 3mM β-Me, 5% Trehalose, 0.02% Tween 20, pH 7.0
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	自收到之日起 12 个月，-20 至 -70 °C。1 个月，复溶后无菌条件下 2 至 8 °C。3 个月，复溶后在无菌条件下 -20 至 -70 °C。收货后建议分装。避免冻融循环。
分子类型	蛋白质

图片

Protein Bioactivity: Recombinant Human Galectin-1 Protein (rp146257)

Recombinant Human Galectin-1 Protein (rp146257) - Protein Bioactivity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10.0 ng/mL.

SDS-PAGE: Recombinant Human Galectin-1 Protein (rp146257)

Recombinant Human Galectin-1 Protein (rp146257) - SDS-PAGE
Recombinant Human Galectin-1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 14.6 kDa.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101626	分析证书	rp146257
ZJ23F1101627	分析证书	rp146257
ZJ23F1101628	分析证书	rp146257

可替换产品

引用文献

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2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al.. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat Genet, 36 (1): (40-5). [PMID:14702039]
3. Walzel H, Schulz U, Neels P, Brock J. (1999) Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.. Immunol Lett, 67 (3): (193-202). [PMID:10369126]
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5. Perillo NL, Pace KE, Seilhamer JJ, Baum LG. Apoptosis of T cells mediated by galectin-1.. Nature, [PMID:7501023]
6. Thomas R Burkard,Melanie Planyavsky,Ines Kaupe,Florian P Breitwieser,Tilmann Bürckstümmer,Keiryn L Bennett,Giulio Superti-Furga,Jacques Colinge. (2011-01-29) Initial characterization of the human central proteome.. BMC systems biology, 5 (17-17). [PMID:21269460]
7. Oberg CT, Blanchard H, Leffler H, Nilsson UJ.. (2008) Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8.. Bioorg Med Chem Lett, 18 (13): (3691-3694). [PMID:18539029] [10.1016/j.bmcl.2008.05.066]
8. Delaine T, Cumpstey I, Ingrassia L, Le Mercier M, Okechukwu P, Leffler H, Kiss R, Nilsson UJ.. (2008) Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells.. J Med Chem, 51 (24): (8109-8114). [PMID:19053747] [10.1021/jm801077j]
9. Dings RP, Miller MC, Nesmelova I, Astorgues-Xerri L, Kumar N, Serova M, Chen X, Raymond E, Hoye TR, Mayo KH.. (2012) Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding.. J Med Chem, 55 (11): (5121-5129). [PMID:22575017] [10.1021/jm300014q]
10. Rajput VK, MacKinnon A, Mandal S, Collins P, Blanchard H, Leffler H, Sethi T, Schambye H, Mukhopadhyay B, Nilsson UJ.. (2016) A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model.. J Med Chem, 59 (17): (8141-8147). [PMID:27500311] [10.1021/acs.jmedchem.6b00957]
11. Gabr M,Rehman AU,Chen HF. (2020) Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling.. ACS Med Chem Lett, 11 (9): (1759-1765). [PMID:32944144] [10.1021/acsmedchemlett.0c00330]
12. Gitt, M A MA and Barondes, S H SH.. (1991) Genomic sequence and organization of two members of a human lectin gene family.. Biochemistry, (8): [PMID:1988031]
13. Sharma, A A, Chemelli, R R and Allen, H J HJ.. (1990) Human splenic galaptin: physicochemical characterization.. Biochemistry, (5): [PMID:2383549]
14. Abbott, W M WM and Feizi, T T.. (1989) Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene.. The Biochemical journal, (1): [PMID:2719646]
15. Hirabayashi, J J, Ayaki, H H, Soma, G G and Kasai, K K.. (1989) Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.. Biochimica et biophysica acta, (1): [PMID:2719964]
16. Couraud, P O PO and 5 more authors.. (1989) Molecular cloning, characterization, and expression of a human 14-kDa lectin.. The Journal of biological chemistry, (15): [PMID:2910856]
17. Hirabayashi, J J and Kasai, K K.. (1988) Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta.. Journal of biochemistry, [PMID:3065332]
18. Hirabayashi, J J, Kawasaki, H H, Suzuki, K K and Kasai, K K.. (1987) Further characterization and structural studies on human placenta lectin.. Journal of biochemistry, [PMID:3611046]
19. Dunham, I I and 24 more authors.. (1999) The DNA sequence of human chromosome 22.. Nature, (2): [PMID:10591208]
20. Fouillit, M M and 8 more authors.. (2000) Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells.. Glycobiology, [PMID:10764829]
21. Tinari, N N and 5 more authors.. (2001) Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.. International journal of cancer, (15): [PMID:11146440]
22. Gevaert, Kris K and 6 more authors.. (2003) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.. Nature biotechnology, [PMID:12665801]
23. Matsuda, Akio A and 11 more authors.. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.. Oncogene, (22): [PMID:12761501]
24. He, Jiale J and Baum, Linda G LG.. (2004) Presentation of galectin-1 by extracellular matrix triggers T cell death.. The Journal of biological chemistry, (6): [PMID:14617626]
25. Collins, John E JE and 12 more authors.. (2004) A genome annotation-driven approach to cloning the human ORFeome.. Genome biology, [PMID:15461802]
26. Nishi, Nozomu N and 8 more authors.. (2008) Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.. Glycobiology, [PMID:18796645]
27. Than, Nandor Gabor NG and 17 more authors.. (2008) Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance.. Proceedings of the National Academy of Sciences of the United States of America, (14): [PMID:18824694]
28. Di Lella, Santiago S and 5 more authors.. (2009) Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose.. Biochemistry, (3): [PMID:19128029]
29. Than, Nandor Gabor NG and 24 more authors.. (2009) A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.. Proceedings of the National Academy of Sciences of the United States of America, (16): [PMID:19497882]
30. Bienvenut, Willy V WV and 6 more authors.. (2012) Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features.. Molecular & cellular proteomics : MCP, [PMID:22223895]
31. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378]
32. Rosenow, Anja A and 6 more authors.. (2012) Resveratrol-induced changes of the human adipocyte secretion profile.. Journal of proteome research, (7): [PMID:22905912]
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35. Escoda-Ferran, Cristina C and 8 more authors.. (2014) Modulation of CD6 function through interaction with Galectin-1 and -3.. FEBS letters, (25): [PMID:24945728]
36. Tagliabracci, Vincent S VS and 14 more authors.. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome.. Cell, (18): [PMID:26091039]
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体积（添加到小瓶中）

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所需的复溶浓度

Recombinant Human Galectin-1 Protein

库存信息

库存信息

库存信息

库存信息

基本描述

储存与运输

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器