Recombinant Human EGFR Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: P00533
蛋白标签: C-His
生物活性: Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 25.83 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 28.96 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC50 of 45.18 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Serclutamab (anti-EGFR) (Ab182867) with the EC50 of 35.7 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 23.66 ng/mL.
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp176273-10μg	10μg	现货
rp176273-50μg	50μg	现货
rp176273-100μg	100μg	现货
rp176273-1mg	1mg	期货

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点击查看蛋白信息: EGFR

Accession#:P00533 (38) Egfr (255) Gene ID:1956 (39)

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基本描述

产品名称	Recombinant Human EGFR Protein
别名	重组人EGFR蛋白 \| 重组人表皮生长因子受体 \| 重组人 EGFR 蛋白
英文别名	cell growth inhibiting protein 40 \| avian erythroblastic leukemia viral (v-erb-b) oncogene homolog \| cell proliferation-inducing protein 61 \| EC 2.7.10 \| EC 2.7.10.1 \| EGF R \| EGFR \| epidermal growth factor receptor (avian erythroblastic leukemia viral (v
规格或纯度	ActiBioPure™, 生物活性, 无动物源, Carrier Free, ≥95%(SDS-PAGE)
产品介绍	Protein Function： As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
生物活性	Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab (anti-EGFR) (Ab182750) with the EC50 of 25.83 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Depatuxizumab mafodotin (anti-EGFR) (Ab175508) with the EC50 of 28.96 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Nimotuzumab (anti-EGFR) (Ab175612) with the EC50 of 45.18 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Serclutamab (anti-EGFR) (Ab182867) with the EC50 of 35.7 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL. Immobilized Recombinant Human EGFR Protein (rp176273) at 1.0 μg/mL can bind Panitumumab (anti-EGFR) (Ab169317) with the EC50 of 23.66 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	1-645 aa
序列	MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSHHHHHH
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P00533
来源	重组表达
预测分子量	69.4 kDa
SDS-PAGE	99.6 kDa, under reducing conditions; 99.6 kDa, under non-reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

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