Vm24, K 通道阻断器 v1.3

级别和纯度:

Moligand™

有货

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货号 (SKU)	包装规格	是否现货	价格	数量
rp175388-500μg	500μg	期货
rp175388-1mg	1mg	期货

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Kv1.3 Channel blocker (13)

基本描述

KCNA3 Tclin 钾电压门控通道亚家族 A 成员 3(Potassium voltage-gated channel subfamily A member 3) (0 活性数据)

点击查看靶蛋白信息： KCNA3

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CAS编号和信息	rp175388

C of A & Other Certificates(BSE/TSE, COO):

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1. Varga Z, Gurrola-Briones G, Papp F, Rodríguez de la Vega RC, Pedraza-Alva G, Tajhya RB, Gaspar R, Cardenas L, Rosenstein Y, Beeton C et al.. (2012) Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.. Mol Pharmacol, 82 (3): (372-82). [PMID:22622363]
2. Gurrola GB, Hernández-López RA, Rodríguez de la Vega RC, Varga Z, Batista CV, Salas-Castillo SP, Panyi G, del Río-Portilla F, Possani LD. (2012) Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.. Biochemistry, 51 (19): (4049-61). [PMID:22540187]
3. Veytia-Bucheli JI, Jiménez-Vargas JM, Melchy-Pérez EI, Sandoval-Hernández MA, Possani LD, Rosenstein Y. (2018) K_v1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4⁺ effector memory T cell response to TCR stimulation.. Cell Commun Signal, 16 (1): (45). [PMID:30107837]