| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp174973-500μg |
500μg |
期货  |
| |
| rp174973-1mg |
1mg |
期货 |
|
| 产品名称 | setmelanotide, 黑色素皮质受体 4 激动剂 |
|---|---|
| 别名 | 美拉诺肽 |
| 英文别名 | 1504602-49-6 | Setmelanotide | Setmelanotide [USAN:INN] | EX-A5542 | SETMELANOTIDE [WHO-DD] | Setmelanotide [USAN] | Setmelanotide acetate | RM-493 | AT23144 | BIM-22493 | (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentan |
| 规格或纯度 | Moligand™ |
| 作用类型 | 激动剂 |
| 作用机制 | 黑色素皮质受体 4 激动剂 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| CAS编号和信息 | rp174973 |
|---|---|
| 分子类型 | 蛋白质 |
| 1. Kumar KG, Sutton GM, Dong JZ, Roubert P, Plas P, Halem HA, Culler MD, Yang H, Dixit VD, Butler AA. (2009) Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice.. Peptides, 30 (10): (1892-900). [PMID:19646498] |
| 2. Farooqi IS, O'Rahilly S. (2008) Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity.. Nat Clin Pract Endocrinol Metab, 4 (10): (569-77). [PMID:18779842] |
| 3. Fani L, Bak S, Delhanty P, van Rossum EF, van den Akker EL. (2014) The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.. Int J Obes (Lond.), 38 (2): (163-9). [PMID:23774329] |
| 4. Kühnen P, Clément K, Wiegand S, Blankenstein O, Gottesdiener K, Martini LL, Mai K, Blume-Peytavi U, Grüters A, Krude H. (2016) Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.. N Engl J Med, 375 (3): (240-6). [PMID:27468060] |
| 5. Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD et al.. (2015) RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.. J Clin Endocrinol Metab, 100 (4): (1639-45). [PMID:25675384] |
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