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macrophage migration inhibitory factor

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货号 (SKU) 包装规格 是否现货 价格 数量
rp174502-500μg
500μg 期货 Stock Image
rp174502-1mg
1mg 期货 Stock Image

基本描述

产品名称 macrophage migration inhibitory factor
别名 巨噬细胞移动抑制因子
英文别名 L-dopachrome isomerase | MMIF
规格或纯度 Moligand™

关联靶点(人)

MIF Tchem 巨噬细胞移动抑制因子(Macrophage migration inhibitory factor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

储存与运输

CAS编号和信息 rp174502

质检证书(CoA,COO,BSE/TSE 和分析图谱)

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引用文献

1. Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E.  (1999)  Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity..  Biochemistry,  38  (22): (7346-54).  [PMID:10353846]
2. Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, Beach DH.  (1999)  A proinflammatory cytokine inhibits p53 tumor suppressor activity..  J Exp Med,  190  (10): (1375-82).  [PMID:10562313]
3. Mitchell RA, Liao H, Chesney J, Fingerle-Rowson G, Baugh J, David J, Bucala R.  (2002)  Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response..  Proc Natl Acad Sci USA,  99  (1): (345-50).  [PMID:11756671]
4. Cvetkovic I, Stosic-Grujicic S.  (2006)  Neutralization of macrophage migration inhibitory factor-novel approach for the treatment of immunoinflammatory disorders..  Int Immunopharmacol,  (10): (1527-34).  [PMID:16919824]
5. Shi X, Leng L, Wang T, Wang W, Du X, Li J, McDonald C, Chen Z, Murphy JW, Lolis E et al..  (2006)  CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex..  Immunity,  25  (4): (595-606).  [PMID:17045821]
6. Flaster H, Bernhagen J, Calandra T, Bucala R.  (2007)  The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity..  Mol Endocrinol,  21  (6): (1267-80).  [PMID:17389748]
7. Nguyen MT, Beck J, Lue H, Fünfzig H, Kleemann R, Koolwijk P, Kapurniotu A, Bernhagen J.  (2003)  A 16-residue peptide fragment of macrophage migration inhibitory factor, MIF-(50-65), exhibits redox activity and has MIF-like biological functions..  J Biol Chem,  278  (36): (33654-71).  [PMID:12796500]
8. Meyer-Siegler KL, Iczkowski KA, Leng L, Bucala R, Vera PL.  (2006)  Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells..  J Immunol,  177  (12): (8730-9).  [PMID:17142775]
9. Morand EF.  (2005)  New therapeutic target in inflammatory disease: macrophage migration inhibitory factor..  Intern Med J,  35  (7): (419-26).  [PMID:15958113]
10. Cherepkova OA, Lyutova EM, Eronina TB, Gurvits BY.  (2006)  Chaperone-like activity of macrophage migration inhibitory factor..  Int J Biochem Cell Biol,  38  (1): (43-55).  [PMID:16099194]
11. Thiele M, Bernhagen J.  (2005)  Link between macrophage migration inhibitory factor and cellular redox regulation..  Antioxid Redox Signal,  (9-10): (1234-48).  [PMID:16115028]
12. Binsky I, Haran M, Starlets D, Gore Y, Lantner F, Harpaz N, Leng L, Goldenberg DM, Shvidel L, Berrebi A et al..  (2007)  IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival..  Proc Natl Acad Sci USA,  104  (33): (13408-13).  [PMID:17686984]
13. Stosic-Grujicic S, Stojanovic I, Nicoletti F.  (2009)  MIF in autoimmunity and novel therapeutic approaches..  Autoimmun Rev,  (3): (244-9).  [PMID:18721909]
14. Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L et al..  (2007)  MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment..  Nat Med,  13  (5): (587-96).  [PMID:17435771]
15. Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F et al..  (2010)  Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast..  Proc Natl Acad Sci USA,  107  (25): (11313-8).  [PMID:20534506]
16. Alampour-Rajabi S, El Bounkari O, Rot A, Müller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A, Bernhagen J.  (2015)  MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis..  FASEB J,  29  (11): (4497-511).  [PMID:26139098]
17. Thiele M, Kerschbaumer RJ, Tam FW, Völkel D, Douillard P, Schinagl A, Kühnel H, Smith J, McDaid JP, Bhangal G et al..  (2015)  Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions..  J Immunol,  195  (5): (2343-52).  [PMID:26209628]
18. Richard V, Kindt N, Saussez S.  (2015)  Macrophage migration inhibitory factor involvement in breast cancer (Review)..  Int J Oncol,  47  (5): (1627-33).  [PMID:26412712]
19. Schinagl A, Kerschbaumer RJ, Sabarth N, Douillard P, Scholz P, Voelkel D, Hollerweger JC, Goettig P, Brandstetter H, Scheiflinger F et al..  (2018)  Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch..  Biochemistry,  57  (9): (1523-1532).  [PMID:29412660]
20. Trivedi-Parmar V, Jorgensen WL.  (2018)  Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor..  J Med Chem,  61  (18): (8104-8119).  [PMID:29812929]
21. Bucala R.  (1994)  Identification of MIF as a new pituitary hormone and macrophage cytokine and its role in endotoxic shock..  Immunol Lett,  43  (1-2): (23-6).  [PMID:7737686]
22. Bernhagen J, Calandra T, Mitchell RA, Martin SB, Tracey KJ, Voelter W, Manogue KR, Cerami A, Bucala R.  (1993)  MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia..  Nature,  365  (6448): (756-9).  [PMID:8413654]
23. Sun HW, Swope M, Cinquina C, Bedarkar S, Bernhagen J, Bucala R, Lolis E.  (1996)  The subunit structure of human macrophage migration inhibitory factor: evidence for a trimer..  Protein Eng,  (8): (631-5).  [PMID:8875640]
24. Rosengren E, Bucala R, Aman P, Jacobsson L, Odh G, Metz CN, Rorsman H.  (1996)  The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction..  Mol Med,  (1): (143-9).  [PMID:8900542]
25. Kleemann R, Mischke R, Kapurniotu A, Brunner H, Bernhagen J.  (1998)  Specific reduction of insulin disulfides by macrophage migration inhibitory factor (MIF) with glutathione and dihydrolipoamide: potential role in cellular redox processes..  FEBS Lett,  430  (3): (191-6).  [PMID:9688536]
26. Bloom J, Metz C, Nalawade S, Casabar J, Cheng KF, He M, Sherry B, Coleman T, Forsthuber T, Al-Abed Y.  (2016)  Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential..  J Biol Chem,  291  (51): (26502-26514).  [PMID:27793992]

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