| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp174479-500μg |
500μg |
期货  |
| |
| rp174479-1mg |
1mg |
期货 |
|
| 产品名称 | LY3540378 (Volenrelaxin), RXFP1 的激动剂 |
|---|---|
| 英文别名 | LY3540378 | Volenrelaxin | Relaxin-2 | RLN2 | relaxin 2 | H2 | RLXH2 | H2-RLX | bA12D24.1.1 | bA12D24.1.2 |
| 规格或纯度 | Moligand™, BioReagent, 低内毒素, ≥90%(SDS-PAGE) |
| 生化机理 | Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. |
| 产品介绍 |
LY3540378 is a a long-acting relaxin analogue [1]. It is composed a human relaxin mimetic peptide fused to a serum albumin-binding VHH domain. It is selective for relaxin family peptide receptor 1 (RXFP1) compared to RXFP2, 3 and 4. VHH-serum albumin binding extends the peptide's circulating half-life. |
| 内毒素水平 | <1.0 EU/mg |
| 表达系统 | CHO |
| 种属 | 人(Human) |
| 蛋白标签 | No tag |
| Accession # | P04090 |
| 来源 | 重组表达 |
| 预测分子量 | 21.8 kDa |
| 作用类型 | 激动剂 |
| 作用机制 | RXFP1 的激动剂 |
| 物理形态 | 液体 |
|---|---|
| 储存缓冲液 | PBS |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 储存在-80℃（3年）；收货后建议分装，避免反复冻融。 |
| CAS编号和信息 | rp174479 |
| 分子类型 | 蛋白质 |
LY3540378 (Volenrelaxin) (rp174479) - SDS-PAGE
2 μg/lane of LY3540378 (Volenrelaxin) (rp174479) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 20 - 24 kDa.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ25F0522088 |
分析证书 | rp174479 |
| 1. Verdino P, Lee SL, Cooper FN, Cottle SR, Grealish PF, Hu CC, Meyer CM, Lin J, Copeland V, Porter G et al.. (2023) Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.. Br J Pharmacol, [PMID:36780899] [10.1111/bph.16055] |
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