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IL-36 receptor antagonist, 白细胞介素-36 受体拮抗剂

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp174310-500μg
500μg 期货 Stock Image
rp174310-1mg
1mg 期货 Stock Image

基本描述

产品名称 IL-36 receptor antagonist, 白细胞介素-36 受体拮抗剂
别名 IL-36 受体拮抗剂
英文别名 IL-1 related protein 3 (IL1RP3) | IL-1F5 | IL-36ra | IL1F5 | interleukin 1 family member 5 (delta)
规格或纯度 Moligand™
作用类型 拮抗剂
作用机制 白细胞介素-36 受体拮抗剂

关联靶点(人)

IL1RL2 Tbio 白细胞介素-1 受体类 2(Interleukin-1 receptor-like 2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
IL1RAP Tclin 白细胞介素-1受体辅助蛋白(Interleukin-1 receptor accessory protein) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

储存与运输

CAS编号和信息 rp174310

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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引用文献

1. Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE.  (1999)  IL1HY1: A novel interleukin-1 receptor antagonist gene..  Biochem Biophys Res Commun,  263  (3): (702-6).  [PMID:10512743]
2. Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M et al..  (2011)  Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis..  N Engl J Med,  365  (7): (620-8).  [PMID:21848462]
3. Abbas O, Itani S, Ghosn S, Kibbi AG, Fidawi G, Farooq M, Shimomura Y, Kurban M.  (2013)  Acrodermatitis continua of Hallopeau is a clinical phenotype of DITRA: evidence that it is a variant of pustular psoriasis..  Dermatology (Basel),  226  (1): (28-31).  [PMID:23428889]
4. Kanazawa N, Nakamura T, Mikita N, Furukawa F.  (2013)  Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis..  J Dermatol,  40  (9): (749-51).  [PMID:23834760]
5. Gresnigt MS, van de Veerdonk FL.  (2013)  Biology of IL-36 cytokines and their role in disease..  Semin Immunol,  25  (6): (458-65).  [PMID:24355486]
6. Tauber M, Bal E, Pei XY, Madrange M, Khelil A, Sahel H, Zenati A, Makrelouf M, Boubridaa K, Chiali A et al..  (2016)  IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases..  J Invest Dermatol,  136  (9): (1811-9).  [PMID:27220475]
7. Ganesan R, Raymond EL, Mennerich D, Woska Jr JR, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D et al..  (2017)  Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies..  MAbs,  (7): (1143-1154).  [PMID:28726542]

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