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IL-17A, 白细胞介素-17 受体激动剂

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp174282-500μg
500μg 期货 Stock Image
rp174282-1mg
1mg 期货 Stock Image

基本描述

产品名称 IL-17A, 白细胞介素-17 受体激动剂
别名 CTLA-8;interleukin-17 alpha
英文别名 CTLA-8;interleukin-17 alpha
规格或纯度 Moligand™
作用类型 激动剂
作用机制 白细胞介素-17 受体激动剂

关联靶点(人)

IL17RA Tclin 白细胞介素-17受体A(Interleukin-17 receptor A) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
IL17RC Tclin 白细胞介素-17受体C(Interleukin-17 receptor C) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

储存与运输

CAS编号和信息 rp174282

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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引用文献

1. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q et al..  (2005)  A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17..  Nat Immunol,  (11): (1133-41).  [PMID:16200068]
2. Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A.  (2009)  Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis..  J Invest Dermatol,  129  (9): (2175-83).  [PMID:19295614]
3. Onishi RM, Gaffen SL.  (2010)  Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease..  Immunology,  129  (3): (311-21).  [PMID:20409152]
4. Lin AM, Rubin CJ, Khandpur R, Wang JY, Riblett M, Yalavarthi S, Villanueva EC, Shah P, Kaplan MJ, Bruce AT.  (2011)  Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis..  J Immunol,  187  (1): (490-500).  [PMID:21606249]
5. Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J et al..  (2011)  Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation..  Immunity,  35  (4): (596-610).  [PMID:21982596]
6. Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, Russell CB.  (2013)  The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings..  J Invest Dermatol,  133  (1): (17-26).  [PMID:22673731]
7. Zhu S, Qian Y.  (2012)  IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential..  Clin Sci,  122  (11): (487-511).  [PMID:22324470]
8. Cai Y, Fleming C, Yan J.  (2013)  Dermal γδ T cells--a new player in the pathogenesis of psoriasis..  Int Immunopharmacol,  16  (3): (388-91).  [PMID:23499509]
9. Ganesan R, Rasool M.  (2017)  Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis..  Mol Immunol,  91  (134-144).  [PMID:28898718]
10. Ishibashi N, Watanabe T, Kanehira M, Watanabe Y, Hoshikawa Y, Notsuda H, Noda M, Sakurada A, Ohkouchi S, Kondo T et al..  (2018)  Bone marrow mesenchymal stromal cells protect allograft lung transplants from acute rejection via the PD-L1/IL-17A axis..  Surg Today,  48  (7): (726-734).  [PMID:29546496]

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