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CXCL12α, ACKR3 激动剂;CXCR3 激动剂;CXCR4 激动剂

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp173767-500μg
500μg 期货 Stock Image
rp173767-1mg
1mg 期货 Stock Image

基本描述

产品名称 CXCL12α, ACKR3 激动剂;CXCR3 激动剂;CXCR4 激动剂
别名 CXCL12 α | SDF-1α | stromal cell-derived factor-1α
英文别名 CXCL12 α | SDF-1α | stromal cell-derived factor-1α
规格或纯度 Moligand™
作用类型 激动剂
作用机制 ACKR3 激动剂;CXCR3 激动剂;CXCR4 激动剂

关联靶点(人)

CXCR4 Tclin CXC 趋化因子受体 4 型(C-X-C chemokine receptor type 4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CXCR3 Tchem CXC 趋化因子受体 3 型(C-X-C chemokine receptor type 3) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ACKR3 Tchem 非典型趋化因子受体 3(Atypical chemokine receptor 3) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

储存与运输

CAS编号和信息 rp173767

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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引用文献

1. Sierro F, Biben C, Martínez-Muñoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martínez-A C, Mackay CR, Mackay F.  (2007)  Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7..  Proc Natl Acad Sci USA,  104  (37): (14759-64).  [PMID:17804806]
2. Patrussi L, Baldari CT.  (2011)  The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection..  Curr Med Chem,  18  (4): (497-512).  [PMID:21143114]
3. Ray P, Stacer AC, Fenner J, Cavnar SP, Meguiar K, Brown M, Luker KE, Luker GD.  (2015)  CXCL12-γ in primary tumors drives breast cancer metastasis..  Oncogene,  34  (16): (2043-51).  [PMID:24909174]
4. Wang C, Chen W, Shen J.  (2018)  CXCR7 Targeting and Its Major Disease Relevance..  Front Pharmacol,  (641).  [PMID:29977203]
5. Nguyen HH, Kim MB, Wilson RJ, Butch CJ, Kuo KM, Miller EJ, Tahirovic YA, Jecs E, Truax VM, Wang T et al..  (2018)  Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties..  J Med Chem,  61  (16): (7168-7188).  [PMID:30052039]
6. Krikun G.  (2018)  The CXL12/CXCR4/CXCR7 axis in female reproductive tract disease: Review..  Am J Reprod Immunol,  80  (5): (e13028).  [PMID:30106199]
7. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T.  (1996)  Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1..  Nature,  382  (6592): (635-8).  [PMID:8757135]
8. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S et al..  (1998)  The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract..  Nature,  393  (6685): (591-4).  [PMID:9634237]
9. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR.  (1998)  Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development..  Nature,  393  (6685): (595-9).  [PMID:9634238]

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