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alpha1-proteinase inhibitor, 弹性蛋白酶抑制剂;表达中性粒细胞

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp173422-500μg
500μg 期货 Stock Image
rp173422-1mg
1mg 期货 Stock Image

基本描述

产品名称 alpha1-proteinase inhibitor, 弹性蛋白酶抑制剂;表达中性粒细胞
别名 α1蛋白酶抑制剂
英文别名 A1AT | A1PI | alpha 1-antitrypsin | Aralast,Prolastin,serum trypsin inhibitor
规格或纯度 Moligand™
作用类型 抑制剂
作用机制 弹性蛋白酶抑制剂;表达中性粒细胞

关联靶点(人)

ELANE Tclin 中性粒细胞弹性蛋白酶(Neutrophil elastase) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

储存与运输

CAS编号和信息 rp173422
分子类型 蛋白质

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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引用文献

1. Mordwinkin NM, Louie SG.  (2007)  Aralast: an alpha 1-protease inhibitor for the treatment of alpha-antitrypsin deficiency..  Expert Opin Pharmacother,  (15): (2609-14).  [PMID:17931094]
2. Kolarich D, Turecek PL, Weber A, Mitterer A, Graninger M, Matthiessen P, Nicolaes GA, Altmann F, Schwarz HP.  (2006)  Biochemical, molecular characterization, and glycoproteomic analyses of alpha(1)-proteinase inhibitor products used for replacement therapy..  Transfusion,  46  (11): (1959-77).  [PMID:17076852]
3. Stocks JM, Brantly M, Pollock D, Barker A, Kueppers F, Strange C, Donohue JF, Sandhaus R.  (2006)  Multi-center study: the biochemical efficacy, safety and tolerability of a new alpha1-proteinase inhibitor, Zemaira..  COPD,  (1): (17-23).  [PMID:17175661]
4. Stocks JM, Brantly ML, Wang-Smith L, Campos MA, Chapman KR, Kueppers F, Sandhaus RA, Strange C, Turino G.  (2010)  Pharmacokinetic comparability of Prolastin®-C to Prolastin® in alpha₁-antitrypsin deficiency: a randomized study..  BMC Clin Pharmacol,  10  (13).  [PMID:20920295]
5. Mast AE, Salvesen G, Schnebli HP, Pizzo SV.  (1990)  Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential..  J Lab Clin Med,  116  (1): (58-65).  [PMID:2376698]
6. Sandhaus RA, Stocks J, Rouhani FN, Brantly M, Strauss P.  (2014)  Biochemical efficacy and safety of a new, ready-to-use, liquid alpha-1-proteinase inhibitor, GLASSIA (alpha1-proteinase inhibitor (human), intravenous)..  COPD,  11  (1): (17-25).  [PMID:23822603]
7. Hubbard RC, McElvaney NG, Sellers SE, Healy JT, Czerski DB, Crystal RG.  (1989)  Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency..  J Clin Invest,  84  (4): (1349-54).  [PMID:2794066]

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