Recombinant Human ErbB3/HER3 Protein

COA

级别和纯度:

≥90%(SDS-PAGE)

表达系统: HEK293
Accession #: P21860
蛋白标签: C-His
生物活性: Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp170123-10μg	10μg	现货
rp170123-50μg	50μg	现货
rp170123-100μg	100μg	现货
rp170123-1mg	1mg	期货

查看相关系列

Accession#:P21860 (10) ERBB3 (11) Gene ID:2065 (10) HER3 (11)

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基本描述

产品名称	Recombinant Human ErbB3/HER3 Protein
别名	重组人ErbB3/HER3蛋白 \| 重组人 ErbB3/HER3 蛋白
英文别名	EC 2.7.10 \| EC 2.7.10.1 \| ErbB3 \| ErbB-3 \| erbB3-S \| HER3 \| HER3c-erbB-3 \| LCCS2 \| lethal congenital contracture syndrome 2 \| MDA-BF-1 \| MGC88033 \| p180-ErbB3 \| p45-sErbB3 \| c-erbB3 \| p85-sErbB3 \| Proto-oncogene-like protein c-ErbB-3 \| receptor tyrosine-p
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, ≥90%(SDS-PAGE)
产品介绍	Protein Function:： ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
生物活性	Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL. Immobilized Recombinant Human ErbB3 / HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	1-643 aa
序列	MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTHHHHHH
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P21860
来源	重组表达
预测分子量	69.5 kDa
SDS-PAGE	81.5-101.9 kDa, under reducing conditions; 74.3-99.3 kDa, under non-reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS, pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

图片

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Barecetamab (anti-ERBB3) (Ab182928) with the EC50 of 14.55 ng/mL.

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Lumretuzumab (anti-ERBB3) (Ab182754) with the EC50 of 31.62 ng/mL.

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC50 of 17.20 ng/mL.

ELISA: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - ELISA
Immobilized Recombinant Human ErbB3/HER3 Protein (rp170123) at 1.0 μg/mL can bind Patritumab (anti-ERBB3) (Ab170705) with the EC50 of 27.08 ng/mL.

SDS-PAGE: Recombinant Human ErbB3/HER3 Protein (rp170123)

Recombinant Human ErbB3/HER3 Protein (rp170123) - SDS-PAGE
3 μg/lane of Recombinant Human ErbB3/HER3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 81.5-101.9 kDa under reducing conditions and 74.3-99.3 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0708304	分析证书	rp170123
ZJ24F0708305	分析证书	rp170123
ZJ24F0708306	分析证书	rp170123

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