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Recombinant Human IL-36Ra/IL-1F5 Protein

Recombinant Human IL-36Ra/IL-1F5 Protein

COA

级别和纯度:

无载体

无叠氮钠

≥95%(SDS-PAGE)

表达系统: E. coli
Accession #: Q9UBH0
蛋白标签: No tag
生物活性: Testing in progress
内毒素水平: <1.0 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp169668-10μg	10μg	现货
rp169668-50μg	50μg	现货
rp169668-100μg	100μg	现货
rp169668-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: IL36RN

Accession#: Q9UBH0 (1) Gene ID: 26525 (1) IL-36Ra/IL-1F5 (2) IL36RN (2)

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基本描述

产品名称	Recombinant Human IL-36Ra/IL-1F5 Protein
别名	重组人IL-36Ra/IL-1F5蛋白 \| 重组人IL-36Ra/IL-1F5蛋白 \| 重组人 IL-36Ra/IL-1F5 蛋白
英文别名	interleukin 1 family, member 5 (delta) \| interleukin 1, delta \| Interleukin 36 Receptor Antagonist \| interleukin-1 family member 5 \| Interleukin-1 receptor antagonist homolog 1 \| Interleukin-1-like protein 1 \| Interleukin-36 Receptor Antagonist \| Interleu
规格或纯度	无载体, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity: >95%, by SDS-PAGE visualized with Coomassie® Blue Staining Description: Human interleukin-36 receptor antagonist [IL-36Ra; previously IL-1F5 and also named FIL-1δ (delta), IL1HY1, IL1H3, and IL-1L1] is a member of the IL1 family of proteins. IL1 family members include IL-1 beta, IL-1 alpha, IL-1ra, IL18 and IL-1F5-F10. All family members show a 12 beta -strand, beta -trefoil configuration, and all family members are believed to have arisen from a common ancestral gene that underwent multiple duplications. The human IL36Ra/IL1F5 gene is in closest proximity to the gene for IL-1ra and is likely a relatively recent duplication of the IL-1ra gene. IL-36Ra/IL-1F5 is synthesized as a 155 amino acid (aa) protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site(s). Nevertheless, it appears to be secreted as a 17 kDa monomer. There is an alternate start site that potentially gives rise to an alternate splice form. The translated product, however, has a premature stop codon, resulting in a truncated 16 aa peptide. Human to mouse, full-length IL-1F5 has 90% aa identity. Within the family, IL-36Ra/IL-1F5 is 50% aa identical to IL-1ra, and 32%, 31%, 35%, 37%, 32% and 42% aa identical to IL-1 beta, IL-36 alpha /IL1F6, IL37/IL1F7, IL36 beta /IL1F8, IL36 gamma /IL1F9 and IL1F10, respectively. Cells reported to express IL36Ra/IL-1F5 include monocytes, B cells, dendritic cells/Langerhans cells, keratinocytes, and gastric fundus Parietal and Chief cells. The receptor for IL-36Ra/IL-1F5 has not been positively identified. Indirect evidence suggests it is IL-1 Rrp2 and/or IL-1 RAcP. In either case, activity association with receptor binding is also unclear. It was initially reported to be an antagonist of IL36 gamma /IL1F9 activity. This would be consistent with its hypothesized relationship to IL1ra. Studies, however, find IL-36Ra/IL-1F5 antagonist activity difficult to demonstrate.
生物活性	Testing in progress
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	2-155 aa
序列	VLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVILGVQGGSQCLSCGVGQEPTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD
蛋白标签	No tag
无载体	Yes
无动物源	No
Accession #	Q9UBH0
来源	重组表达
预测分子量	16.8 kDa
SDS-PAGE	14.2 kDa, under reducing conditions; 14.0 &14.3 kDa, under reducing conditions

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from PBS pH 7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可稳定保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human IL-36Ra/IL-1F5 Protein (rp169668)

Recombinant Human IL-36Ra/IL-1F5 Protein (rp169668) - SDS-PAGE
3 μg/lane of Recombinant Human IL-36Ra/IL-1F5 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 14.2 kDa under reducing conditions and 14.0 & 14.3 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0404520	分析证书	rp169668
ZJ24F0404521	分析证书	rp169668
ZJ24F0404522	分析证书	rp169668

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