货号 (SKU)

包装规格

是否现货

价格

数量

rp169653-10μg

10μg

现货

rp169653-50μg

50μg

现货

rp169653-100μg

100μg

期货

rp169653-1mg

1mg

期货

基本描述

产品名称	Recombinant Human TSLP Protein
别名	重组人TSLP蛋白 \| 重组人 TSLP 蛋白
英文别名	thymic stromal lymphopoietin \| TSLP \| Thymic stromal lymphopoietin protein TSLP \| TSLP protein \| TSLP_HUMAN \| EC 1.3.5.1 \| Ip \| Iron-sulfur subunit of complex II
规格或纯度	ActiBioPure™, Bioactive, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+ TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.
生物活性	Immobilized Recombinant Human TSLP Protein (rp169653) at 2.0 μg/mL can bind Tezepelumab (anti-TSLP) (Ab170833) with the EC50 of 18.04 ng/mL.
内毒素水平	<1.0 EU/μg
表达系统	E. coli
种属	人(Human)
氨基酸	29-159 aa
序列	MGSSHHHHHHSSGLVPRGSYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ
纯度	>95%(SDS-PAGE)
蛋白标签	N-His
无载体	Yes
无动物源	No
Accession #	Q969D9
来源	重组表达
预测分子量	17.0 kDa
SDS-PAGE	15.4 kDa, reducing conditions

储存与运输

物理形态	透明胶状
储存缓冲液	Lyophilized from PBS, 2.5%Glycerol, 1mM EDTA, pH7.4
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.1 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human TSLP Protein (rp169653)

Recombinant Human TSLP Protein (rp169653) - SDS-PAGE
Recombinant Human TSLP Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 15.4 kDa.

ELISA: Recombinant Human TSLP Protein (rp169653)

Recombinant Human TSLP Protein (rp169653) - ELISA
Immobilized Recombinant Human TSLP Protein (rp169653) at 2.0 μg/mL can bind Tezepelumab (anti-TSLP) (Ab170833) with the EC₅₀ of 18.04 ng/mL.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F1101771	分析证书	rp169653
ZJ23F1101772	分析证书	rp169653
ZJ23F1101773	分析证书	rp169653

技术文档和文章

阿拉丁®靶点蛋白

Categories: 技术文章

探索主题:

药物开发信号通路细胞因子靶点蛋白药物靶点受体免疫检查点细胞表面标记物

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引用文献

1. Kita, K K, Oya, H H, Gennis, R B RB, Ackrell, B A BA and Kasahara, M M.. (1990) Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria.. Biochemical and biophysical research communications, (15): [PMID:2302193]
2. Gould, S J SJ, Subramani, S S and Scheffler, I E IE.. (1989) Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2494655]
3. Au, H C HC and 5 more authors.. (1995) Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase.. Gene, (4): [PMID:7622059]
4. Astuti, D D and 9 more authors.. (2001) Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.. American journal of human genetics, [PMID:11404820]
5. Baysal, B E BE and 11 more authors.. (2002) Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas.. Journal of medical genetics, [PMID:11897817]
6. Neumann, Hartmut P H HP and 29 more authors.. (2002) Germ-line mutations in nonsyndromic pheochromocytoma.. The New England journal of medicine, (9): [PMID:12000816]
7. Young, Abbie L AL, Baysal, Bora E BE, Deb, Arjun A and Young, William F WF.. (2002) Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene.. The Journal of clinical endocrinology and metabolism, [PMID:12213855]
8. Benn, Diana E DE and 9 more authors.. (2003) Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas.. Oncogene, (6): [PMID:12618761]
9. Gimenez-Roqueplo, Anne-Paule AP and 10 more authors.. (2003) Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.. Cancer research, (1): [PMID:14500403]
10. Maier-Woelfle, Margarete M and 10 more authors.. (2004) A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas.. The Journal of clinical endocrinology and metabolism, [PMID:14715873]
11. Astuti, Dewi D and 13 more authors.. (2003) Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility.. Clinical endocrinology, [PMID:14974914]
12. Neumann, Hartmut P H HP and 16 more authors.. (2004) Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.. JAMA, (25): [PMID:15328326]
13. McDonnell, Ciara M CM, Benn, Diana E DE, Marsh, Deborah J DJ, Robinson, Bruce G BG and Zacharin, Margaret R MR.. (2004) K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma.. Clinical endocrinology, [PMID:15473885]
14. Kullberg, Morgan M, Nilsson, Maria A MA, Arnason, Ulfur U, Harley, Eric H EH and Janke, Axel A.. (2006) Housekeeping genes for phylogenetic analysis of eutherian relationships.. Molecular biology and evolution, [PMID:16751257]
15. van Nederveen, Francien H FH, Korpershoek, Esther E, Lenders, Jacques W M JW, de Krijger, Ronald R RR and Dinjens, Winand N M WN.. (2007) Somatic SDHB mutation in an extraadrenal pheochromocytoma.. The New England journal of medicine, (19): [PMID:17634472]
16. (2007) Familial gastrointestinal stromal tumors and germ-line mutations.. The New England journal of medicine, (6): [PMID:17804857]
17. Ni, Ying Y and 9 more authors.. (2008) Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes.. American journal of human genetics, [PMID:18678321]
18. Alston, Charlotte L CL and 12 more authors.. (2012) Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency.. Journal of medical genetics, [PMID:22972948]
19. Helman, Guy G and 13 more authors.. (2016) Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy.. Annals of neurology, [PMID:26642834]
20. Maio, Nunziata N and 9 more authors.. (2016) Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.. Cell metabolism, (9): [PMID:26749241]
21. Ardissone, Anna and 5 more authors.. (2015) Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance.. Molecular genetics and metabolism reports, [PMID:26925370]
22. Grønborg, Sabine S and 10 more authors.. (2017) Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.. JIMD reports, [PMID:27604842]
23. Kaur, Parneet; Sharma, Suvasini; Kadavigere, Rajagopal; Girisha, Katta Mohan and Shukla, Anju.. (2020) Novel variant p.(Ala102Thr) in SDHB causes mitochondrial complex II deficiency: Case report and review of the literature.. Annals of human genetics, [PMID:32124427]
24. Saribas, Sami and Safak, Mahmut.. (2020) A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions.. Viruses, (20): [PMID:33092197]

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复溶计算器

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体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Recombinant Human TSLP Protein

库存信息

库存信息

库存信息

库存信息

基本描述

储存与运输

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

技术文档和文章

可替换产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器