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Recombinant Mouse IL-13 Protein

  • 表达系统: E. coli
  • Accession #: P20109
  • 蛋白标签: No tag
  • 生物活性: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <4ng/mL.
  • 内毒素水平: <0.01 EU/μg
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货号 (SKU) 包装规格 是否现货 价格 数量
rp154139-10μg
10μg 现货 Stock Image
rp154139-20μg
20μg 现货 Stock Image
rp154139-100μg
100μg 现货 Stock Image
rp154139-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Mouse IL-13 Protein
别名 重组小鼠 IL-13 蛋白
英文别名 Allergic rhinitis | ALRH | BHR 1 | BHR1 | Bronchial hyperresponsiveness 1 (bronchial asthma) | IL 13 | IL-13 | Il13 | IL13_HUMAN | Interleukin 13 | Interleukin-13 | interleukin13 | MGC116786 | MGC116788 | MGC116789 | NC 30 | NC30 | P 600 | P60
规格或纯度 ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, High performance, ≥98%(SDS-PAGE&HPLC)
产品介绍


Murine Interleukin-13 (IL-13) is expressed by the IL13 gene located on the chromosome 11 and secreted by many cell types, especially T helper type 2 (Th2) cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human, mouse and rat IL-13 share low homology, but have cross species activity. Recombinant Murine IL-13 is a 12.3kDa protein consisting of 111 amino acid residues


Purity

>98%(SDS-PAGE,HPLC)


Function

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses . Positively regulates IL31RA expression in macrophages.


生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <4ng/mL.
内毒素水平 <0.01 EU/μg
表达系统 E. coli
种属 小鼠(Mouse)
氨基酸 22-131 aa
序列 MPVPRSVSLPLTLKELIEELSNITQDQTPLCNGSMVWSVDLAAGGF CVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVSSLPDTKIEVAHF ITKLLSYTKQLFRHGPF
纯度 >98%(SDS-PAGE,HPLC)
蛋白标签 No tag
蛋白长度 Full length protein
无载体 Yes
无动物源 Yes
Accession # P20109
来源 重组表达
预测分子量 12.3 kDa

储存与运输

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4
复溶 1、 This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. 2、 Reconstitute in a sterile aqueous buffer to an appropriate concentration.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 长期储存时,产品应≤ -20℃。避免冷冻/解冻循环。
分子类型 蛋白质

图片

Recombinant Mouse IL-13 Protein (rp154139)-Protein Bioactivity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is typically <4ng/mL.

Recombinant Mouse IL-13 Protein (rp154139)-SDS-PAGE
3μg/lane of Recombinant Mouse IL-13 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a single band at 11.2 kDa.

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批号(Lot Number) 证书类型 货号
ZJ25F0420961 分析证书 rp154139
ZJ25F0420960 分析证书 rp154139
ZJ25F0420959 分析证书 rp154139
ZJ23F0400124 分析证书 rp154139
ZJ23F0400125 分析证书 rp154139

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