Recombinant Human Nectin-2/CD112 Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: Q92692
蛋白标签: No tag
生物活性: Recombinant Human Nectin-2/CD112 Protein is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human DNAM-1/CD226 hFc has been identified as an interactor of Nectin-2, thus a binding ELISA assay was conducted to detect the interaction of recombinant human Nectin-2 and recombinant DNAM-1/CD226 hFc.
内毒素水平: <1.0 EU/μg

有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
rp149154-10μg	10μg	现货
rp149154-50μg	50μg	现货
rp149154-100μg	100μg	现货
rp149154-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: NECTIN2

Accession#:Q92692 (3) CD112 (5) Gene ID:5819 (3) NECTIN2 (3)

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基本描述

产品名称	Recombinant Human Nectin-2/CD112 Protein
别名	重组人NECTIN2蛋白 \| 重组人粘连蛋白2 \| 重组人类 Nectin-2/CD112 蛋白
英文别名	CD112 antigen \| CD112 \| Herpes virus entry mediator B \| Herpesvirus entry mediator B \| herpesvirus entry protein B \| HVEB \| poliovirus receptor-like 2 \| MPH \| nectin 2 \| Nectin2 \| Nectin-2 \| poliovirus receptor-related 2 (herpesvirus entry mediator B) \| p
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity >95% SDS-PAGE. Function Probable cell adhesion protein.
生物活性	Recombinant Human Nectin-2/CD112 Protein is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human DNAM-1/CD226 hFc has been identified as an interactor of Nectin-2, thus a binding ELISA assay was conducted to detect the interaction of recombinant human Nectin-2 and recombinant DNAM-1/CD226 hFc.
内毒素水平	<1.0 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	32-360 aa
序列	QDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLADDDDK
纯度	＞95%(SDS-PAGE)
蛋白标签	No tag
无载体	Yes
无动物源	Yes
Accession #	Q92692
来源	重组表达
预测分子量	36.2 kDa
SDS-PAGE	46.6 kDa, under reducing conditions; 40.0 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from sterile 1*PBS
复溶	It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25mg/mL.
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	样品自收到之日起在 -70 ℃ 下可稳定保存 12 个月。收到样品后在无菌条件下保存，温度为 -20 ℃ 至 -80 ℃。建议将蛋白质分装成较小的量，以达到最佳储存效果。避免反复冻融循环。
分子类型	蛋白质

图片

Protein Bioactivity: Recombinant Human Nectin-2/CD112 Protein (rp149154)

Recombinant Human Nectin-2/CD112 Protein (rp149154) - Protein Bioactivity
Recombinant Human Nectin-2/CD112 Protein (rp149154) is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Human DNAM-1/CD226 hFc has been identified as an interactor of Nectin-2/CD112, thus a binding ELISA assay was conducted to detect the interaction of recombinant human Nectin-2/CD112 and recombinant DNAM-1/CD226 hFc.

SDS-PAGE: Recombinant Human Nectin-2/CD112 Protein (rp149154)

Recombinant Human Nectin-2/CD112 Protein (rp149154) - SDS-PAGE
2.5 μg/lane of Recombinant Human Nectin-2/CD112 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 46.6 kDa under reducing conditions and 40.0 kDa under non-reducing conditions.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ23F0700638	分析证书	rp149154
ZJ23F0700639	分析证书	rp149154
ZJ23F0700637	分析证书	rp149154

技术文档和文章

引用文献

1. Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H et al.. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.. Nat Immunol, 10 (1): (48-57). [PMID:19011627]
2. Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH. (2016) Identification of CD112R as a novel checkpoint for human T cells.. J Exp Med, 213 (2): (167-76). [PMID:26755705]
3. Eberlé, F F, Dubreuil, P P, Mattei, M G MG, Devilard, E E and Lopez, M M.. (1995) The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene.. Gene, (4): [PMID:7622062]
4. Warner, M S MS and 8 more authors.. (1998) A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.. Virology, (20): [PMID:9657005]
5. Freitas, E M EM and 7 more authors.. (1998) Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.. DNA sequence : the journal of DNA sequencing and mapping, [PMID:10520737]
6. Martinez, W M WM and Spear, P G PG.. (2001) Structural features of nectin-2 (HveB) required for herpes simplex virus entry.. Journal of virology, [PMID:11602758]
7. Pende, Daniela D and 13 more authors.. (2005) PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.. Molecular immunology, [PMID:15607800]
8. Samanta, Dibyendu D and 5 more authors.. (2012) Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:22927415]

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