Recombinant Human Lactoferrin Protein

3篇引用文献

级别和纯度:

≥95%(SDS-PAGE)

表达系统: 水稻(Oryza sativa)
Accession #: AAA59511.1
蛋白标签: No tag
内毒素水平: <20 EU/mg

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货号 (SKU)	包装规格	是否现货
rp148153-10mg	10mg	现货
rp148153-100mg	100mg	现货
rp148153-1g	1g	现货

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点击查看蛋白信息: LTF

Accession#: AAA59511.1 (1) Apoptosis (7108) Bacterial (5911) Fungal (1689) Gene ID:4057 (2) Lactoferrin (2) LF (1) LTF (2)

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基本描述

产品名称	Recombinant Human Lactoferrin Protein
别名	重组人Lactoferrin蛋白 \| 重组人乳铁传递蛋白 \| 重组人乳铁蛋白
英文别名	EC 3.4.21.- \| Growth-inhibiting protein 12 \| Lactoferrin \| Talalactoferrin \| Growth inhibiting protein 12 \| HLF2 \| Kaliocin 1 \| Lactoferrin \| Lactoferroxin-C \| Lactotransferrin \| LF \| LTF \| Neutrophil lactoferrin \| Talalactoferrin \| TRFL_HUMAN \| HEL110 \|
规格或纯度	ActiBioPure™, GMP, Animal Free, Carrier Free, ≥95%(SDS-PAGE)
生化机理	Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.
内毒素水平	<20 EU/mg
表达系统	水稻(Oryza sativa)
种属	人(Human)
氨基酸	1-711 aa
序列	MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDEGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK
蛋白标签	No tag
无载体	Yes
无动物源	Yes
Accession #	AAA59511.1
来源	重组表达
预测分子量	80 kDa
SDS-PAGE	80 kDa, under reducing conditions; 65 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Na2HPO3, NaH2PO3, NaCl, pH 5.2-7.2.
复溶	Reconstitute in sterile PBS to a concentration of 10 mg/ml. After dissolution, sterile OsrhLF can be stored at 4 ℃ for 1 month.
储存温度	2-8°C储存
运输条件	冰袋运输
稳定性与储存	在 2-8℃ 下保存 24 个月。收货后建议分装。
CAS编号和信息	146897-68-9
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human Lactoferrin Protein (rp148153)

Recombinant Human Lactoferrin Protein (rp148153) - SDS-PAGE
1 μg/lane of Recombinant Human Lactoferrin Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 80 kDa under reducing conditions and 65 kDa under non-reducing conditions.

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批号(Lot Number)	证书类型	货号
ZJ24F0910109	分析证书	rp148153
ZJ24F0809570	分析证书	rp148153
ZJ24F0809569	分析证书	rp148153

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引用文献

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22. Faber, H R HR, Baker, C J CJ, Day, C L CL, Tweedie, J W JW and Baker, E N EN.. (1996) Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants.. Biochemistry, (19): [PMID:8931543]
23. Nicholson, H H and 5 more authors.. (1997) Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant.. Biochemistry, (14): [PMID:9003186]
24. Siebert, P D PD and Huang, B C BC.. (1997) Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:9122171]
25. van Berkel, P H PH and 5 more authors.. (1997) N-terminal stretch Arg2, Arg3, Arg4 and Arg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA.. The Biochemical journal, (15): [PMID:9359845]
26. Klintworth, G K GK and 21 more authors.. (1998) Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.. Molecular vision, (31): [PMID:9873069]
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28. Jameson, G B GB, Anderson, B F BF, Norris, G E GE, Thomas, D H DH and Baker, E N EN.. (1998) Structure of human apolactoferrin at 2.0 A resolution. Refinement and analysis of ligand-induced conformational change.. Acta crystallographica. Section D, Biological crystallography, (1): [PMID:10089508]
29. Abrink, M M, Larsson, E E, Gobl, A A and Hellman, L L.. (2000) Expression of lactoferrin in the kidney: implications for innate immunity and iron metabolism.. Kidney international, [PMID:10792619]
30. Peterson, N A NA, Anderson, B F BF, Jameson, G B GB, Tweedie, J W JW and Baker, E N EN.. (2000) Crystal structure and iron-binding properties of the R210K mutant of the N-lobe of human lactoferrin: implications for iron release from transferrins.. Biochemistry, (6): [PMID:10828980]
31. Lupetti, A A and 5 more authors.. (2000) Candidacidal activities of human lactoferrin peptides derived from the N terminus.. Antimicrobial agents and chemotherapy, [PMID:11083624]
32. Baker, H M HM, Baker, C J CJ, Smith, C A CA and Baker, E N EN.. (2000) Metal substitution in transferrins: specific binding of cerium(IV) revealed by the crystal structure of cerium-substituted human lactoferrin.. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, [PMID:11128996]
33. Nibbering, P H PH and 6 more authors.. (2001) Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria.. Infection and immunity, [PMID:11179314]
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35. Jameson, Geoffrey B GB and 5 more authors.. (2002) Structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally twinned crystal form.. Acta crystallographica. Section D, Biological crystallography, [PMID:12037297]
36. Singh, Pradeep K PK, Parsek, Matthew R MR, Greenberg, E Peter EP and Welsh, Michael J MJ.. (2002) A component of innate immunity prevents bacterial biofilm development.. Nature, (30): [PMID:12037568]
37. Peterson, Neil A NA and 5 more authors.. (2002) "Dilysine trigger" in transferrins probed by mutagenesis of lactoferrin: crystal structures of the R210G, R210E, and R210L mutants of human lactoferrin.. Biochemistry, (3): [PMID:12450380]
38. Hendrixson, D R DR and 7 more authors.. (2003) Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites.. Molecular microbiology, [PMID:12535064]
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51. Johansson, Cecilia C and 8 more authors.. (2007) Adenoviruses use lactoferrin as a bridge for CAR-independent binding to and infection of epithelial cells.. Journal of virology, [PMID:17079302]
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58. Hardivillé, Stéphan S, Hoedt, Esthelle E, Mariller, Christophe C, Benaïssa, Monique M and Pierce, Annick A.. (2010) O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin.. The Journal of biological chemistry, (18): [PMID:20404350]
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62. Binbin Hu, Huaqiang Fang, Zhixin Huang, Wenjing Huang, Li Huang, Huijie Liu, Fanzhen Lv, Wei Huang, Xiaolei Wang. (2023) An upconversion nanoplatform based multi-effective theatment for Parkinson’s disease. CHEMICAL ENGINEERING JOURNAL, 465 (142959). [10.1016/j.cej.2023.142959]
63. Yanyan Xu, Xiangtong Ye, Yanfeng Du, Wenqin Yang, Fan Tong, Wei Li, Qianqian Huang, Yongke Chen, Hanmei Li, Huile Gao, Weiwei Zhang. (2025) Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer’s disease therapy. Acta Pharmaceutica Sinica B, [10.1016/j.apsb.2025.02.035]
64. Yu Zhang, Ning Ma, Lu Wang, Liming Liu, Tianze Wang, Hao Liu, Weiping Qian. (2024) Real-Time Study of the Specific Interactions of Lactoferrin with Mimicked Heparan Sulfate Meshes Using Ordered Porous Layer Interferometry. ANALYTICAL CHEMISTRY, 96 (36): (14413-14423). [PMID:38989558] [10.1021/acs.analchem.4c01808]

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