Recombinant Human IL-23R Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: Q5VWK5-1
蛋白标签: C-hFc
生物活性: Immobilized Human IL- 12B&IL-23A Protein at 5.0 μg/mL can bind Recombinant Human IL-23R Protein (rp147522) with the ED50 is 128.2 ng/mL.
内毒素水平: <0.1 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp147522-10μg	10μg	现货
rp147522-50μg	50μg	现货
rp147522-100μg	100μg	现货
rp147522-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: IL23R

Accession#: Q5VWK5 (1) Gene ID: 149233 (1) IL-23 receptor (1) Il23r (2)

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基本描述

产品名称	Recombinant Human IL-23R Protein
别名	重组人IL-23R蛋白 \| 重组人 IL-23R 蛋白
英文别名	IL-23 receptor \| IL-23R \| IBD17 \| IL-23 R \| IL-23 receptor \| IL23R \| IL-23R \| interleukin 23 receptor \| interleukin-23 receptor \| PSORS7
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity ≥95% SDS-PAGE. Endotoxin level <0.1 EU/µg Function Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
生物活性	Immobilized Human IL- 12B&IL-23A Protein at 5.0 μg/mL can bind Recombinant Human IL-23R Protein (rp147522) with the ED50 is 128.2 ng/mL.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	24-355 aa
序列	GITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGENLYFQGMDPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
纯度	≥95% (SDS-PAGE)
蛋白标签	C-hFc
无载体	Yes
无动物源	Yes
Accession #	Q5VWK5-1
来源	重组表达
预测分子量	65 kDa
SDS-PAGE	90 - 110 kDa, under reducing conditions; 200 - 200 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
分子类型	蛋白质

图片

Protein Bioactivity: Recombinant Human IL-23R Protein (rp147522)

Recombinant Human IL-23R Protein (rp147522) - Protein Bioactivity
Immobilized Human IL- 12B&IL-23A Protein at 5.0 μg/mL can bind Recombinant Human IL-23R Protein (rp147522) with the ED50 is 128.2 ng/mL.

SDS-PAGE: Recombinant Human IL-23R Protein (rp147522)

Recombinant Human IL-23R Protein (rp147522) - SDS-PAGE
3 μg/lane of Recombinant Human IL-23R Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 90 - 110 kDa under reducing condition and 200 - 220 kDa under non-reducing condition.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0809864	分析证书	rp147522
ZJ24F0809865	分析证书	rp147522
ZJ24F0809866	分析证书	rp147522

技术文档和文章

引用文献

1. Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L, Timms K, Gutin A, Abkevic V, Burden AD et al.. (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.. Hum Genet, 122 (2): (201-6). [PMID:17587057]
2. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F et al.. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.. J Immunol, 168 (11): (5699-708). [PMID:12023369]
3. Zhang, Xiang-Yue XY and 7 more authors.. (2006) Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells.. Immunogenetics, [PMID:16372191]
4. Duerr, Richard H RH and 22 more authors.. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.. Science (New York, N.Y.), (1): [PMID:17068223]
5. Raelson, John V JV and 24 more authors.. (2007) Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.. Proceedings of the National Academy of Sciences of the United States of America, (11): [PMID:17804789]
6. Hüffmeier, Ulrike U and 10 more authors.. (2009) Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.. The Journal of investigative dermatology, [PMID:18800148]

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